Comparison of T2-FLAIR images obtained at 3 T and 7 T.

<p>In all patients, all lesions detected at 3 T were also visible at 7 T. Boxed areas are shown at higher magnification. A) Patient No. 3, with a small chronic lesion consisting of hyperintense postischemic tissue (white arrowheads) surrounding a tissue defect area (asterisk); compare also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037631#pone-0037631-g002" target="_blank">figure 2</a> A. At 7 T, the intensity values of the tissue defect area were comparable to CSF, while at 3 T, the intensity values were comparable to white matter. Contrast between postischemic and healthy brain tissue was higher at 3 T. However, small white matter lesions (red arrowheads) were easier to identify at 7 T. B) Patient No. 1, with a chronic stroke lesion (white arrowheads) and a subacute lesion (red arrowheads). Both lesion types were readily identifiable at both field strengths. As in A), contrast between the lesion and healthy tissue appeared to be higher at 3 T. C) Patient No. 4, with a large chronic infarct, consisting of hyperintense lesion areas (white arrowheads) and hypointense defect areas (asterisks). Again, CSF-filled tissue defect areas were easier to identify at 7 T, while the lesion to healthy tissue contrast was higher at 3 T. Compare also fig. 2 A–C.</p

Comparison of T2-weighted imaging performed at 3 T and 7 T.

<p>Boxed areas are shown at higher magnification. A) In patient No. 3, artifacts were present (red arrowheads). Contrast and detail level of the lesion (white arrowhead) and of Virchow-Robin spaces were not higher at 7 T. B) In contrast, in patient No. 1 no artifacts were present. Virchow Robin spaces (white arrowheads) were depicted in higher detail at 7 T and the delineation of the lesion (red arrowheads) from healthy tissue was higher at 7 T. C) Same patient as in B). Also in the region of the deep nuclei T2-weighted imaging at 7 T showed better delineation, e.g. between deep nuclei (red asterisks) and fibre bundles of the internal capsule (white asterisks).</p

Synopsis of the parameters of the imaging techniques used.

<p> <i>TR: repetition time; TE: echo time; BW: Bandwidth; FA: flip angle; t = time.</i></p

Comparison of MR-angiographies derived from 3D TOF acquisitions at 3 T and 7 T.

<p>In all patients, TOF at 7 T was able to depict the branches of the main cerebral arteries in higher anatomical detail. In patients No. 4 (A) and No. 7 (B), the left MCA territory is shown in higher magnification. In comparison with 3 T, clearly more first and second order branches were visible at 7 T in comparison with 3 T (white arrowheads).</p

Comparison of T₁-weighted images derived from T1-MPRAGE at 3 T and 7 T.

<p>In all patients, MPRAGE at 7 T depicted the internal structure of stroke lesion in higher detail compared with 3 T. Boxed areas are shown at higher magnification. A) Patient No. 3. The tissue defect area appeared larger and less well confined at 3 T in contrast to 7 T (white arrowheads). Virchow-Robin spaces were seen in more detail and higher frequency at 7 T (red arrowheads). B) In patient No. 1, the chronic stroke lesion (white arrowheads) presented as an hypointense area – indicating gliosis – and as a disruption of the cortical band. These characteristics of the lesion were depicted in higher detail level and contrast at 7 T. The subacute lesion (red arrowheads) showed a different internal structure of the cortical band compared with healthy cortex. Within the lesion, the cortical band was divided into a superficial hyperintense layer and a deeper hypointense layer (asterisks). Differentiation of the two layers was much easier at 7 T. C) Patient No. 4. In this large infarct, differentiation of hypointense gliosis (white arrowheads) and healthy tissue was again clearer at 7 T. Inhomogeneities between the frontal and occipital cortex and paramedian deep structures – typical for 7 T – were more pronounced in this patient compared to A) and B).</p

Comparison of T2*-weighted images acquired with HemoFLASH at 3 T and 7 T.

<p>In all patients, HemoFLASH provided higher anatomic detail level at 7 T. Moreover, hypointense perilesional hemosiderin deposits were much more pronounced at 7 T. Boxed areas are shown at higher magnification. A) In patient No 3, anatomical detail level and contrast of the lesion (white arrowheads) to healthy tissue were higher at 7 T imaging. T2-FLAIR weighted high magnification images are shown for comparison below. A perilesional hypointense area, indicating hemosiderin deposits, was much more pronounced at 7 T (red arrowheads). B) In patient No. 4, again both anatomical details as well as the imaging of hemosiderin (white arrowheads) were superior at 7 T. C) Incidental finding of a cavernous angioma (white arrowhead) in patient No. 5. The internal structure of the lesion, showing a nodular characteristic with a hypointense rim, and the depiction of feeding vessels were more pronounced at 7 T, facilitating the diagnosis.</p