Materialy dlia istorii zhenskago obrazovaniia.

Bibliographical footnotes.v.1. 1086-1798.--v.2. 1796-1828.--v.3. 1828-1856.Mode of access: Internet

The public sector as an adapter for digital innovation

The paper attempts to study the theoretical aspects of digitalization of the economy. Analysis of the current level of development of the digital economy in Russia is presented. An assessment of the current state of digital transformation of the public sector is made. Potential opportunities and threats from the digital economy in relation to the public sector are identified. The prospects for the digital transformation of the public sector economy are identified. The theoretical and practical significance of the work is determined by the novelty of the conclusions and a comprehensive study of the problem with the subsequent systematization of the data. The content of the paper, its main conclusions and provisions can be used both for further in-depth study of digital solutions and their impact on the economy, and for direct guidance on the implementation of digital technologies in the economy

Implementation of Inclusive Education in General Education Institutions

Nowadays much attention is attached to the problem of inclusive education. Inclusive education of children with learning disabilities is a new strategic trend of educational policy of the Republic of Kazakhstan, significantly addressing fundamental education. This article considers the possibility of involving the schoolchildren with learning disabilities in educational process and the necessity to secure favorable environment and support for the children with learning disabilities in accordance with the Law “On Education of the Republic of Kazakhstan” and State Program of Education Development in the Republic of Kazakhstan for 2011–2012.The trend of maximum possible involvement of children with special needs in common general education institutions determines the educational culture dynamics in many countries of the world. Number of European Union countries has already made drastic structural alterations, resulted in the abolition of special schools (Sweden, Denmark, Italy, Australia, USA, etc.). Children with different disabilities study in “the least restrictive environment”, in other words, whenever possible, together with peers in the environment of general education institutions [1].The goal of Kazakhstan development strategy up to 2030, involving the educational system is “to provide the development of the national educational model and its integration into international educational environment”.The priority of state program “Education” (2000–2005) “is to create conditions for efficient development of national educational model, providing access to qualitative education”. “The Concept of Kazakhstan Educational System”, the realization of which should provide: transfer from the principle of “education for life” to the principle of “lifelong education for everyone”; affordability and continuity of all educational levels; comprehensive, qualitative, competitive result-oriented education has been adopte

Spectrum of Causative Mutations in Patients with Hemophilia A in Russia

Hemophilia A (HA) is one of the most widespread, X-linked, inherited bleeding disorders, which results from defects in the F8 gene. Nowadays, more than 3500 different pathogenic variants leading to HA have been described. Mutation analysis in HA is essential for accurate genetic counseling of patients and their relatives. We analyzed patients from 273 unrelated families with different forms of HA. The analysis consisted of testing for intron inversion (inv22 and inv1), and then sequencing all functionally important F8 gene fragments. We identified 101 different pathogenic variants in 267 patients, among which 35 variants had never been previously reported in international databases. We found inv22 in 136 cases and inv1 in 12 patients. Large deletions (1–8 exons) were found in 5 patients, and we identified a large insertion in 1 patient. The remaining 113 patients carried point variants involving either single nucleotide or several consecutive nucleotides. We report herein the largest genetic analysis of HA patients issued in Russia

Spectrum of Causative Mutations in Patients with Hemophilia A in Russia

Hemophilia A (HA) is one of the most widespread, X-linked, inherited bleeding disorders, which results from defects in the F8 gene. Nowadays, more than 3500 different pathogenic variants leading to HA have been described. Mutation analysis in HA is essential for accurate genetic counseling of patients and their relatives. We analyzed patients from 273 unrelated families with different forms of HA. The analysis consisted of testing for intron inversion (inv22 and inv1), and then sequencing all functionally important F8 gene fragments. We identified 101 different pathogenic variants in 267 patients, among which 35 variants had never been previously reported in international databases. We found inv22 in 136 cases and inv1 in 12 patients. Large deletions (1–8 exons) were found in 5 patients, and we identified a large insertion in 1 patient. The remaining 113 patients carried point variants involving either single nucleotide or several consecutive nucleotides. We report herein the largest genetic analysis of HA patients issued in Russia