1 research outputs found
Transition-Metal-Free, Atom- and Step-Economic Synthesis of Aminoketopyrrolizines from Benzylamine, Acylethynylpyrroles, and Acylacetylenes
A concise, atom-economic
strategy for the synthesis of pyrrolizines
with amino and keto substituents has been developed. It includes the
following key steps: (i) the base-catalyzed (K<sub>3</sub>PO<sub>4</sub>/DMSO) addition of a benzylamine to 2-acylethynylpyrroles and (ii)
noncatalyzed addition of enaminones obtained to the triple bond of
acylacetylenes followed by intramolecular cyclization of the intermediate
pentadiendiones thus formed to the target 1-(benzylamino)-2-acyl-3-methylenoacylpyrrolizines