Clinical features, evolution and biological characteristics of the ten CLL patients studied.

<p>Summary of the prognosis factors considered in the clinic and genetic lesions that the ten patients harbor. ND = not done, del = deletion.</p

Mutation validation.

<p>Capillary sequencing chromatograms confirming the seven putative variants. <i>KRAS</i>, <i>SMARCA2</i>, <i>PRKD3</i>, <i>STAT6</i>, <i>LIFR</i> and <i>ILB1</i> showed one point mutation each, depicted as two peaks in the tumoral DNA chromatogram. For <i>NFKBIE</i>, the 4-bp deletion was also confirmed. NT = non-tumoral, TM = tumoral. R = A or G; Y = C or T; S = C or G; K = T or G; /…./ = 4-bp deletion.</p

Validated somatic mutation.

<p>CDS: Coding sequence. NA: not annotated. Chr: chromosome.</p

Schematic representation of the mutated proteins with the primary structural domains highlighted.

<p>Schematic representation of the mutated proteins with the primary structural domains highlighted.</p