909 research outputs found
MLA Research Agenda. Systematic Review Project. Team Updates Presentation. MLA Annual Meeting Supplement. May 17, 2015
Most of the 15 systematic review teams provided one-page summaries of their progress to date in compiling systematic reviews on one of 15 top-ranked important research projects. This builds upon an earlier Delphi study that was reported here: Eldredge JD, Ascher MT, Holmes HN, Harris MR. The new Medical Library Association research agenda: final results from a three-phase Delphi study. J Med Libr Assoc. 2012 Jul;100(3):214-8. doi: 10.3163/1536-5050.100.3.012. PubMed PMID: 22879811; PubMed Central PMCID: PMC3411260
Hierarchy Theory of Evolution and the Extended Evolutionary Synthesis: Some Epistemic Bridges, Some Conceptual Rifts
Contemporary evolutionary biology comprises a plural landscape of multiple co-existent conceptual frameworks and strenuous voices that disagree on the nature and scope of evolutionary theory. Since the mid-eighties, some of these conceptual frameworks have denounced the ontologies of the Modern Synthesis and of the updated Standard Theory of Evolution as unfinished or even flawed. In this paper, we analyze and compare two of those conceptual frameworks, namely Niles Eldredgeâs Hierarchy Theory of Evolution (with its extended ontology of evolutionary entities) and the Extended Evolutionary Synthesis (with its proposal of an extended ontology of evolutionary processes), in an attempt to map some epistemic bridges (e.g. compatible views of causation; niche construction) and some conceptual rifts (e.g. extra-genetic inheritance; different perspectives on macroevolution; contrasting standpoints held in the âexternalismâinternalismâ debate) that exist between them. This paper seeks to encourage theoretical, philosophical and historiographical discussions about pluralism or the possible unification of contemporary evolutionary biology
MLA Research Agenda: Appraising the Best Available Evidence
Offers guidelines for the formation and self-governance of autonomous teams as they conduct systematic reviews related to the MLA Research Agenda
How does genetic diversity change towards the range periphery? An empirical and theoretical test
Question: How does genetic diversity change as one moves along a species' range, towards the periphery? Previous work shows contradictory evidence for an increase, decrease or no clear trend along the range
Tangled Nature: A model of emergent structure and temporal mode among co-evolving agents
Understanding systems level behaviour of many interacting agents is
challenging in various ways, here we'll focus on the how the interaction
between components can lead to hierarchical structures with different types of
dynamics, or causations, at different levels. We use the Tangled Nature model
to discuss the co-evolutionary aspects connecting the microscopic level of the
individual to the macroscopic systems level. At the microscopic level the
individual agent may undergo evolutionary changes due to mutations of
strategies. The micro-dynamics always run at a constant rate. Nevertheless, the
system's level dynamics exhibit a completely different type of intermittent
abrupt dynamics where major upheavals keep throwing the system between
meta-stable configurations. These dramatic transitions are described by a
log-Poisson time statistics. The long time effect is a collectively adapted of
the ecological network. We discuss the ecological and macroevolutionary
consequences of the adaptive dynamics and briefly describe work using the
Tangled Nature framework to analyse problems in economics, sociology,
innovation and sustainabilityComment: Invited contribution to Focus on Complexity in European Journal of
Physics. 25 page, 1 figur
Self-Organized Criticality Driven by Deterministic Rules
We have investigated the essential ingredients allowing a system to show Self
Organized Criticality (SOC) in its collective behavior. Using the Bak-Sneppen
model of biological evolution as our paradigm, we show that the random
microscopic rules of update can be effectively substituted with a chaotic map
without changing the universality class. Using periodic maps SOC is preserved,
but in a different universality class, as long as the spectrum of frequencies
is broad enough.Comment: 4 pages, RevTex (tar.gz), 4 eps-figures include
Self-organized criticality in deterministic systems with disorder
Using the Bak-Sneppen model of biological evolution as our paradigm, we
investigate in which cases noise can be substituted with a deterministic signal
without destroying Self-Organized Criticality (SOC). If the deterministic
signal is chaotic the universality class is preserved; some non-universal
features, such as the threshold, depend on the time correlation of the signal.
We also show that, if the signal introduced is periodic, SOC is preserved but
in a different universality class, as long as the spectrum of frequencies is
broad enough.Comment: RevTex, 8 pages, 8 figure
Evolutionary dynamics of the most populated genotype on rugged fitness landscapes
We consider an asexual population evolving on rugged fitness landscapes which
are defined on the multi-dimensional genotypic space and have many local
optima. We track the most populated genotype as it changes when the population
jumps from a fitness peak to a better one during the process of adaptation.
This is done using the dynamics of the shell model which is a simplified
version of the quasispecies model for infinite populations and standard
Wright-Fisher dynamics for large finite populations. We show that the
population fraction of a genotype obtained within the quasispecies model and
the shell model match for fit genotypes and at short times, but the dynamics of
the two models are identical for questions related to the most populated
genotype. We calculate exactly several properties of the jumps in infinite
populations some of which were obtained numerically in previous works. We also
present our preliminary simulation results for finite populations. In
particular, we measure the jump distribution in time and find that it decays as
as in the quasispecies problem.Comment: Minor changes. To appear in Phys Rev
IGRT After Prostatectomy: Evaluation of Corrective Shifts and Toxicity Using Online Cone Beam CT vs. Weekly Port Films for Target Localization
Purpose/Objective(s): Image guidance (IG) may permit higher radiotherapy (RT) doses (\u3e65 Gy) after radical prostatectomy (RP) without increased toxicity, with improved accuracy and smaller margins. Conebeam (CBCT) allows IGRT with volumetric images. This study evaluated CBCT shifts and toxicity after conformal IGRT, compared to RT with port films.
American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, C
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