995 research outputs found
HYDRA: Hybrid Deep Magnetic Resonance Fingerprinting
Purpose: Magnetic resonance fingerprinting (MRF) methods typically rely on
dictio-nary matching to map the temporal MRF signals to quantitative tissue
parameters. Such approaches suffer from inherent discretization errors, as well
as high computational complexity as the dictionary size grows. To alleviate
these issues, we propose a HYbrid Deep magnetic ResonAnce fingerprinting
approach, referred to as HYDRA.
Methods: HYDRA involves two stages: a model-based signature restoration phase
and a learning-based parameter restoration phase. Signal restoration is
implemented using low-rank based de-aliasing techniques while parameter
restoration is performed using a deep nonlocal residual convolutional neural
network. The designed network is trained on synthesized MRF data simulated with
the Bloch equations and fast imaging with steady state precession (FISP)
sequences. In test mode, it takes a temporal MRF signal as input and produces
the corresponding tissue parameters.
Results: We validated our approach on both synthetic data and anatomical data
generated from a healthy subject. The results demonstrate that, in contrast to
conventional dictionary-matching based MRF techniques, our approach
significantly improves inference speed by eliminating the time-consuming
dictionary matching operation, and alleviates discretization errors by
outputting continuous-valued parameters. We further avoid the need to store a
large dictionary, thus reducing memory requirements.
Conclusions: Our approach demonstrates advantages in terms of inference
speed, accuracy and storage requirements over competing MRF method
Disrupted state transition learning as a computational marker of compulsivity
Background: Disorders involving compulsivity, fear, and anxiety are linked to beliefs that the world is less predictable. We lack a mechanistic explanation for how such beliefs arise. Here, we test a hypothesis that in people with compulsivity, fear, and anxiety, learning a probabilistic mapping between actions and environmental states is compromised. // Methods: In Study 1 (n = 174), we designed a novel online task that isolated state transition learning from other facets of learning and planning. To determine whether this impairment is due to learning that is too fast or too slow, we estimated state transition learning rates by fitting computational models to two independent datasets, which tested learning in environments in which state transitions were either stable (Study 2: n = 1413) or changing (Study 3: n = 192). // Results: Study 1 established that individuals with higher levels of compulsivity are more likely to demonstrate an impairment in state transition learning. Preliminary evidence here linked this impairment to a common factor comprising compulsivity and fear. Studies 2 and 3 showed that compulsivity is associated with learning that is too fast when it should be slow (i.e. when state transition are stable) and too slow when it should be fast (i.e. when state transitions change). // Conclusions: Together, these findings indicate that compulsivity is associated with a dysregulation of state transition learning, wherein the rate of learning is not well adapted to the task environment. Thus, dysregulated state transition learning might provide a key target for therapeutic intervention in compulsivity
Towards formal models of psychopathological traits that explain symptom trajectories
BACKGROUND: A dominant methodology in contemporary clinical neuroscience is the use of dimensional self-report questionnaires to measure features such as psychological traits (e.g., trait anxiety) and states (e.g., depressed mood). These dimensions are then mapped to biological measures and computational parameters. Researchers pursuing this approach tend to equate a symptom inventory score (plus noise) with some latent psychological trait. MAIN TEXT: We argue this approach implies weak, tacit, models of traits that provide fixed predictions of individual symptoms, and thus cannot account for symptom trajectories within individuals. This problem persists because (1) researchers are not familiarized with formal models that relate internal traits to within-subject symptom variation and (2) rely on an assumption that trait self-report inventories accurately indicate latent traits. To address these concerns, we offer a computational model of trait depression that demonstrates how parameters instantiating a given trait remain stable while manifest symptom expression varies predictably. We simulate patterns of mood variation from both the computational model and the standard self-report model and describe how to quantify the relative validity of each model using a Bayesian procedure. CONCLUSIONS: Ultimately, we would urge a tempering of a reliance on self-report inventories and recommend a shift towards developing mechanistic trait models that can explain within-subject symptom dynamics
The roles of online and offline replay in planning
Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigated this question by using magnetoencephalography (MEG) to study human subjects while they performed a decision-making task that was designed to reveal the decision algorithms employed. We characterised subjects in terms of how flexibly each adjusted their choices to changes in temporal, spatial and reward structure. The more flexible a subject, the more they replayed trajectories during task performance, and this replay was coupled with re-planning of the encoded trajectories. The less flexible a subject, the more they replayed previously preferred trajectories during rest periods between task epochs. The data suggest that online and offline replay both participate in planning but support distinct decision strategies
Measurement does not always aid state discrimination
We have investigated the problem of discriminating between nonorthogonal
quantum states with least probability of error. We have determined that the
best strategy for some sets of states is to make no measurement at all, and
simply to always assign the most commonly occurring state. Conditions which
describe such sets of states have been derived.Comment: 3 page
Minimum-error discrimination between symmetric mixed quantum states
We provide a solution of finding optimal measurement strategy for
distinguishing between symmetric mixed quantum states. It is assumed that the
matrix elements of at least one of the symmetric quantum states are all real
and nonnegative in the basis of the eigenstates of the symmetry operator.Comment: 10 page
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