2 research outputs found
SHORT COMMUNICATION - Anti-human Immunodeficiency Virus-1 Antibody Titers in Injection Drug Users Compared to Sexually Infected Individuals
Sera from infected injection drug users (IDU) have shown to have
antibodies against synthetic human immunodeficiency virus-1 (HIV-1)
envelope peptides more frequently. In this study, reactivity of 48 IDU
plasma were compared to 60 plasmas obtained from sexually infected
individuals (S). The overall reactivity of plasma from IDU compared to
S was higher, and the reactivity titers were much higher for IDU plasma
than S. IDU plasma also showed a broader antibody response. The higher
reactivity titers were observed mainly for the gp41 immunodominant
epitope and V3 peptides corresponding to the consensus sequences of
HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the
specificity in the higher immune response of IDU