Correction of morphofunctional disorders with asialoerythropoietin and selective inhibitor of arginase II KUD975 in cases of ischemic kidney damage in the experiment

Acute kidney injury (AKI), which is based on ischemic-reperfusion damage, is a widespread life-threatening condition and remains a serious public health problem with a high mortality rate among patients. Pharmacological preconditioning and the use of endothelioprotectors are promising areas in this field, therefore the purpose of this study was to analyze the nephroprotective properties of asialoerythropoietin and selective inhibitor of arginase II KUD975 in ischemic kidney damage in the experimen

Semiorthogonal decompositions of derived categories of equivariant coherent sheaves

Let X be an algebraic variety with an action of an algebraic group G. Suppose X has a full exceptional collection of sheaves, and these sheaves are invariant under the action of the group. We construct a semiorthogonal decomposition of bounded derived category of G-equivariant coherent sheaves on X into components, equivalent to derived categories of twisted representations of the group. If the group is finite or reductive over the algebraically closed field of zero characteristic, this gives a full exceptional collection in the derived equivariant category. We apply our results to particular varieties such as projective spaces, quadrics, Grassmanians and Del Pezzo surfaces.Comment: 28 pages, uses XY-pi

THE CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE HELP OF DISTANT ISCHEMIC AND PHARMACOLOGICAL PRECONDITIONING WITH THERMAL LOCAL ASPHYXIA OF KIDNEY

This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning. The modeling of thermal local asphyxia of kidney is characterized by the disturbance of microcirculation and expression of eNOS in the kidney tissue. The usage of distant ischemic preconditioning and phosphodiesterase inhibitors type 5 sildenafil and tadalafil leads to pronounced correction of microcirculation dysfunction and activity of eNOS. During the modeling of thermal local asphyxia of kidney against endothelium dysfunction caused by ADMA-like L-NAME induced deficiency of nitric oxide more pronounced dysfunction of microcirculation and activity of eNOS are observed. The usage of distant ischemic and pharmacological preconditioning with the help of phosphodiesterase inhibitors type 5 in this type of pathology led to pronounced correction of microcirculation dysfunction and activity of eNOS. The injection of glibenclamide blocker of ATP – dependent K+ channels during the correction of the disturbance caused by the modeling of thermal local asphyxia of kidney with the help of distant ischemic and pharmacological preconditioning leads to the decrease of its efficiency.Disclosure: The study did not have sponsorship. The authors have declared no conflicts of interest

Revisiting the 'LSND anomaly' II: critique of the data analysis

This paper, together with a preceding paper, questions the so-called 'LSND anomaly': a 3.8 sigma excess of antielectronneutrino interactions over standard backgrounds, observed by the LSND Collaboration in a beam dump experiment with 800 MeV protons. That excess has been interpreted as evidence for the antimuonneutrino to antielectronneutrino oscillation in the \Deltam2 range from 0.2 eV2 to 2 eV2. Such a \Deltam2 range is incompatible with the widely accepted model of oscillations between three light neutrino species and would require the existence of at least one light 'sterile' neutrino. In a preceding paper, it was concluded that the estimates of standard backgrounds must be significantly increased. In this paper, the LSND Collaboration's estimate of the number of antielectronneutrino interactions followed by neutron capture, and of its error, is questioned. The overall conclusion is that the significance of the 'LSND anomaly' is not larger than 2.3 sigma.Comment: 30 pages, 16 figures, 6 table

Reply to 'Corrections to the HARP-CDP Analysis of the LSND Neutrino Oscillation Backgrounds'

The alleged mistakes in recent papers that reanalyze the backgrounds to the 'LSND anomaly' do not exist. We maintain our conclusion that the significance of the 'LSND anomaly' is not 3.8 sigma but not larger than 2.3 sigma.Comment: 3 page

Why the paper CERN-PH-EP-2009-015 (arXiv:0903.4762) is scientifically unacceptable

The paper CERN-PH-EP-2009-015 (arXiv:0903.4762) by A. Bagulya et al. violates standards of quality of work and scientific ethics on several counts. The paper contains assertions that contradict established detector physics. The paper falls short of proving the correctness of the authors' concepts and results. The paper ignores or quotes misleadingly pertinent published work. The paper ignores the fact that the authors' concepts and results have already been shown wrong in the published literature. The authors seem unaware that cross-section results from the 'HARP Collaboration' that are based on the paper's concepts and algorithms are in gross disagreement with the results of a second analysis of the same data, and with the results of other experiments.Comment: 8 pages, 3 figure

Cross-sections of large-angle hadron production in proton- and pion-nucleus interactions VII: tin nuclei and beam momenta from \pm3 GeV/c to \pm15 GeV/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary tin target, of proton and pion beams with momentum from \pm3 GeV/c to \pm15 GeV/c. Results are given for secondary particles with production angles between 20 and 125 degrees. Cross-sections on tin nuclei are compared with cross-sections on beryllium, carbon, copper, tantalum and lead nuclei.Comment: 68 pages, 13 figure

Comparison of Geant4 hadron generation with data from the interactions with beryllium nuclei of +8.9 GeV/c protons and pions, and of -8 GeV/c pions

Hadron generation in the Geant4 simulation tool kit is compared with inclusive spectra of secondary protons and pions from the interactions with beryllium nuclei of +8.9 GeV/c protons and pions, and of -8.0 GeV/c pions. The data were taken in 2002 at the CERN Proton Synchrotron with the HARP spectrometer. We report on significant disagreements between data and simulated data especially in the polar-angle distributions of secondary protons and pions.Comment: 15 pages, 13 figure

Cross-Sections of Large-Angle Hadron Production in Proton- and Pion-Nucleus Interactions V: Lead Nuclei and Beam Momenta from +/-3 Gev/c to +/-15 Gev/c

We report on double-differential inclusive cross-sections of the production of secondary protons, charged pions, and deuterons, in the interactions with a 5% nuclear interaction length thick stationary lead target, of proton and pion beams with momentum from +/-3 GeV/c to +/-15 GeV/c. Results are given for secondary particles with production angles 20 to 125 degrees. Cross-sections on lead nuclei are compared with cross-sections on beryllium, copper, and tantalum nuclei.Comment: 67 pages, 13 figures, 47 table

Pad equalization and dE/dx in the HARP TPC

In the HARP TPC, the specific ionization dE/dx depends critically on the pad equalization, which in turn depends on the crosstalk correction. We discuss the TPC pad equalization algorithm and its performance in terms of average and resolution of dE/dx of negative pions with an average active track length of 300 mm. The observed dE/dx of pions and protons agrees satisfactorily with the theoretical expectation, the resolution for a minimum-ionizing track length of 300 mm is 16%