14 research outputs found
Improving the Antimicrobial Activity of Bagasse Packaging Paper using Organophosphorus Dimers
The
antimicrobial properties of
bagasse paper sheets coated with natural polymers (chitosan, different ratios
of (gelatin/glycerol) + chitosan, hemicellulose, hemicellulose + glycerol,
hemicellulose+chitosan) or synthetic organophosphorus dimer compounds were
evaluated in this work. Hemicelluloses showed moderate activity against Bacillus subtilis and Candida albicans, while chitosan showed weak
activity against B. subtilis. The condition that offered the highest inhibitory
activity of
bagasse paper was the one coated with 1,3-diaryl-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane
(where aryl is p-chloroaniline or p-anisidine). The developed bagasse papers
were evaluated against Gram-positive bacteria, Gram-negative bacteria, yeasts, and fungi. The highest inhibitory
activity was obtained at a concentration of 200 mg/mL for p-chloroaniline with
an inhibition zone that varied for different microbes from 6.9 mm to 26 mm. The
highest inhibitory activity was obtained at 300–250 mg/mL for p-anisidine
against most of the pathogenic microorganisms with an inhibition zone that
varied for different microbes from 8 mm to 14.75 mm. The observed antimicrobial and antifungal activity properties
for bagasse paper coated with
1,3-diaryl 2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane could be attributed to the
presence of Cl, P atoms, and the lone pair of electrons on N atoms in the
structure of the dimers
Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas
In this study, a series of newly synthesized substituted pyridine 9, 11−18, naphthpyridine derivative 10 and substituted pyrazolopyridines 19−23 by using cycnopyridone 8 as a starting material. Some of the synthesized candidates are evaluated as anticancer agents against different cancer cell lines. In vitro cytotoxic activities against hepatocellular and cervical carcinoma cell lines were evaluated using standard MTT assay. Different synthesized compounds exhibited potential in vitro cytotoxic activities against both HepG2 and HeLa cell lines. Furthermore, compared to standard positive control drugs, compounds 13 and 19 showed the most potent cytotoxic effect with IC50 values of 8.78 ± 0.7, 5.16 ± 0.4 μg/mL, and 15.32 ± 1.2 and 4.26 ± 0.3 μg/mL for HepG2 and HeLa cells, respectively
Synthesis and biological screening of some chromonyl-substituted heterocycles derived from 2(3 H
Synthesis and Reactions of Novel 2,5-Disubstituted 1,3,4-Thiadiazoles
<div><p></p><p>The desired 1,3,4-thiadiazole compounds bearing different substituents were obtained by the cyclization of the corresponding thiosemicarbazide followed by the reaction with electrophilic reagents, such as aromatic aldehydes, isatin, phenyl isothiocyanate, and carbon disulfide. The newly synthesized 2,5-disubstituted 1,3,4-thiadiazoles were obtained in good yields and their structures were elucidated by spectral data and elemental analysis.</p>
<p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Synthetic Communications</i>® for the following free supplemental resource(s): Full experimental and spectral details.]</p>
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