Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS

Copyright © 2015 The Royal College of OphthalmologistsJournal articleThis is the author’s accepted version of the article; Salmon HA, Chalk D, Stein K, Frost NA (2015) Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS. Eye. doi:10.1038/eye.2015.151BackgroundKeratoconus is a progressive degenerative corneal disorder of children and young adults that is traditionally managed by refractive error correction, with corneal transplantation reserved for the most severe cases. UVA collagen crosslinking is a novel procedure that aims to prevent disease progression, currently being considered for use in the UK NHS. We assess whether it might be a cost-effective alternative to standard management for patients with progressive keratoconus.MethodsWe constructed a Markov model in which we estimated disease progression from prospective follow-up studies, derived costs derived from the NHS National Tariff, and calculated utilities from linear regression models of visual acuity in the better-seeing eye. We performed deterministic and probabilistic sensitivity analyses to assess the impact of possible variations in the model parameters.ResultsCollagen crosslinking is cost effective compared with standard management at an incremental cost of £3174 per QALY in the base case. Deterministic sensitivity analysis shows that this could rise above £33 263 per QALY if the duration of treatment efficacy is limited to 5 years. Other model parameters are not decision significant. Collagen crosslinking is cost effective in 85% of simulations at a willingness-to-pay threshold of £30 000 per QALY.ConclusionUVA collagen crosslinking is very likely to be cost effective, compared with standard management, for the treatment of progressive keratoconus. However, further research to explore its efficacy beyond 5 years is desirable.Eye advance online publication, 28 August 2015; doi:10.1038/eye.2015.151