Frequency of Hereditary Hemochromatosis (HFE) Gene Mutations in Egyptian Beta Thalassemia Patients and its Relation to Iron Overload

AIM: This study aimed to detect the most common HFE gene mutations (C282Y, H63D, and S56C) in Egyptian beta thalassemia major patients and its relation to their iron status. SUBJECTS AND METHODS: The study included 50 beta thalassemia major patients and 30 age and sex matched healthy persons as a control group. Serum ferritin, serum iron and TIBC level were measured. Detection of the three HFE gene mutations (C282Y, H63D and S65C) was done by PCR-RFLP analysis. Confirmation of positive cases for the mutations was done by sequencing.RESULTS: Neither homozygote nor carrier status for the C282Y or S65C alleles was found. The H63D heterozygous state was detected in 5/50 (10%) thalassemic patients and in 1/30 (3.3%) controls with no statistically significant difference between patients and control groups (p = 0.22). Significantly higher levels of the serum ferritin and serum iron in patients with this mutation (p = 001).CONCLUSION: Our results suggest that there is an association between H63D mutation and the severity of iron overload in thalassemic patients

Wetting and evaporation of salt-water nanodroplets: A molecular dynamics investigation

We employ molecular dynamics simulations to study the wetting and evaporation of salt-water nanodroplets on platinum surfaces. Our results show that the contact angle of the droplets increases with the salt concentration. To verify this, a second simulation system of a thin salt-water film on a platinum surface is used to calculate the various surface tensions. We find that both the solid-liquid and liquid-vapor surface tensions increase with salt concentration and as a result these cause an increase in the contact angle. However, the evaporation rate of salt-water droplets decreases as the salt concentration increases, due to the hydration of salt ions. When the water molecules have all evaporated from the droplet, two forms of salt crystals are deposited, clump and ringlike, depending on the solid-liquid interaction strength and the evaporation rate. To form salt crystals in a ring, it is crucial that there is a pinned stage in the evaporation process, during which salt ions can move from the center to the rim of the droplets. With a stronger solid-liquid interaction strength, a slower evaporation rate, and a higher salt concentration, a complete salt crystal ring can be deposited on the surface

Anaerobic digestion and gasification of seaweed

The potential of algal biomass as a source of liquid and gaseous biofuels is a highly topical theme, with over 70 years of sometimes intensive research and considerable financial investment. A wide range of unit operations can be combined to produce algal biofuel, but as yet there is no successful commercial system producing such biofuel. This suggests that there are major technical and engineering difficulties to be resolved before economically viable algal biofuel production can be achieved. Both gasification and anaerobic digestion have been suggested as promising methods for exploiting bioenergy from biomass, and two major projects have been funded in the UK on the gasification and anaerobic digestion of seaweed, MacroBioCrude and SeaGas. This chapter discusses the use of gasification and anaerobic digestion of seaweed for the production of biofuel

Food Supply and Seawater pCO2 Impact Calcification and Internal Shell Dissolution in the Blue Mussel Mytilus edulis

Progressive ocean acidification due to anthropogenic CO2 emissions will alter marine ecosytem processes. Calcifying organisms might be particularly vulnerable to these alterations in the speciation of the marine carbonate system. While previous research efforts have mainly focused on external dissolution of shells in seawater under saturated with respect to calcium carbonate, the internal shell interface might be more vulnerable to acidification. In the case of the blue mussel Mytilus edulis, high body fluid pCO2 causes low pH and low carbonate concentrations in the extrapallial fluid, which is in direct contact with the inner shell surface. In order to test whether elevated seawater pCO2 impacts calcification and inner shell surface integrity we exposed Baltic M. edulis to four different seawater pCO2 (39, 142, 240, 405 Pa) and two food algae (310–350 cells mL−1 vs. 1600–2000 cells mL−1) concentrations for a period of seven weeks during winter (5°C). We found that low food algae concentrations and high pCO2 values each significantly decreased shell length growth. Internal shell surface corrosion of nacreous ( = aragonite) layers was documented via stereomicroscopy and SEM at the two highest pCO2 treatments in the high food group, while it was found in all treatments in the low food group. Both factors, food and pCO2, significantly influenced the magnitude of inner shell surface dissolution. Our findings illustrate for the first time that integrity of inner shell surfaces is tightly coupled to the animals' energy budget under conditions of CO2 stress. It is likely that under food limited conditions, energy is allocated to more vital processes (e.g. somatic mass maintenance) instead of shell conservation. It is evident from our results that mussels exert significant biological control over the structural integrity of their inner shell surfaces

Performance analysis of a CDMA wireless local loop systems

In this paper, the capacity of the Code Division Multiple Access Wireless Local Loop (CDMA WLL) sysytem is analytically derived, and the capacity gain achieved in a CDMA WLL over a cellular mobile environment is calculated. The results show that the CDMA WLL system can support up to 36% more users than CDMA cellular mobile system. The paper also propose a new approach to increase the reverse lonk capacity of the CDMA WLL system, which synchronize the reverse link so that signals transmitted from different subscriber units within the same cell are time aligned at the base station )BS). A theoretical analysis of the potential capacity gain of reverse link synchronous CDMA WLL is presented

Optimizing bandwidth utilization and traffic control in ISP networks for enhanced smart agriculture.

As the demand for high-bandwidth Internet connections continues to surge, industries are exploring innovative ways to harness this connectivity, and smart agriculture stands at the forefront of this evolution. In this paper, we delve into the challenges faced by Internet Service Providers (ISPs) in efficiently managing bandwidth and traffic within their networks. We propose a synergy between two pivotal technologies, Multi-Protocol Label Switching-Traffic Engineering (MPLS-TE) and Diffserv Quality of Service (Diffserv-QoS), which have implications beyond traditional networks and resonate strongly with the realm of smart agriculture. The increasing adoption of technology in agriculture relies heavily on real-time data, remote monitoring, and automated processes. This dynamic nature requires robust and reliable high-bandwidth connections to facilitate data flow between sensors, devices, and central management systems. By optimizing bandwidth utilization through MPLS-TE and implementing traffic control mechanisms with Diffserv-QoS, ISPs can create a resilient network foundation for smart agriculture applications. The integration of MPLS-TE and Diffserv-QoS has resulted in significant enhancements in throughput and a considerable reduction in Jitter. Employment of the IPv4 header has demonstrated impressive outcomes, achieving a throughput of 5.83 Mbps and reducing Jitter to 3 msec