Pramipexole protective effect on rotenone induced neurotoxicity in mice

Introduction: 
Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect. 

Materials and Methods: 
A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexole was tried in a new approach where the treatment began in the middle of rotenone course with oral dose 1mg/kg/day of pramipexole. 

Results: 
Further analysis of behavioral tests and immunohistochemistry revealed success of pramipexole in improving the rotenone intoxicated mice. 

Conclusion: 
These results showed possible beneficial effects of pramipexole against rotenone-induced neurotoxicity

Parkinson's Disease: Is It a Toxic Syndrome?

Parkinson's disease (PD) is one of the neurodegenerative diseases which we can by certainty identify its pathology, however, this confidence disappeares when talking about the cause. A long history of trials, suggestions, and theories tried linking PD to a specific causation. In this paper, a new suggestion is trying to find its way, could it be toxicology? Can we—in the future—look to PD as an occupational disease, in fact, many clues point to the possible toxic responsibility—either total or partial—in causing this disease. Searching for possible toxic causes for PD would help in designing perfect toxic models in animals

Modeling of double-gate LDMOSFET devices including self-heating

[abstract not available

New hybrid frequency reuse method for packet loss minimization in LTE network

This paper investigates the problem of inter-cell interference (ICI) in Long Term Evolution (LTE) mobile systems, which is one of the main problems that causes loss of packets between the base station and the mobile station. Recently, different frequency reuse methods, such as soft and fractional frequency reuse, have been introduced in order to mitigate this type of interference. In this paper, minimizing the packet loss between the base station and the mobile station is the main concern. Soft Frequency Reuse (SFR), which is the most popular frequency reuse method, is examined and the amount of packet loss is measured. In order to reduce packet loss, a new hybrid frequency reuse method is implemented. In this method, each cell occupies the same bandwidth of the SFR, but the total system bandwidth is greater than in SFR. This will provide the new method with a lot of new sub-carriers from the neighboring cells to reduce the ICI which represents a big problem in many applications and causes a lot of packets loss. It is found that the new hybrid frequency reuse method has noticeable improvement in the amount of packet loss compared to SFR method in the different frequency bands. Traffic congestion management in Intelligent Transportation system (ITS) is one of the important applications that is affected by the packet loss due to the large amount of traffic that is exchanged between the base station and the mobile node. Therefore, it is used as a studied application for the proposed frequency reuse method and the improvement in the amount of packet loss reached 49.4% in some frequency bands using the new hybrid frequency reuse method

Dietary Guduchi (Tinospora cordifolia) enhanced the growth performance, antioxidative capacity, immune response and ameliorated stress-related markers induced by hypoxia stress in Nile tilapia (Oreochromis niloticus)

Nile tilapia can tolerate a wide range of farming conditions; however, fluctuations in the environmental conditions may impair their health status. The incorporation of medicinal herbs in aquafeed is suggested to overcome stressful conditions. In this study, dietary Guduchi (Tinospora cordifolia) was evaluated on the growth performance, antioxidative capacity, immune response, and resistance of Nile tilapia against hypoxia stress. Fish fed five diets incorporated with Guduchi at 0, 2, 4, 6, and 8 g/kg for 56 days then exposed with hypoxia stress for 72 h. The growth performance, feed intake, and feed efficiency ratio were significantly (P \u3c 0.05) increased by including Guduchi in tilapia diets regardless of the inclusion level. Similarly, the lipase and protease activities were markedly (P \u3c 0.05) increased in tilapia fed dietary Guduchi. The activities of lysozyme and bactericidal activities in serum and mucus, nitro-blue tetrazolium (NBT), and alternative complement activity (ACH50) were markedly (P \u3c 0.05) enhanced in tilapia treated with Guduchi supplements regardless of the dose. Additionally, the activities of liver and intestinal superoxide dismutase, catalase, and glutathione peroxidase were markedly enhanced (P \u3c 0.05) by including Guduchi in tilapia diets compared with the control. Before and after hypoxia stress, tilapia-fed dietary Guduchi had lower glucose and cortisol levels than fish-fed Guduchi-free diets (P \u3c 0.05). In all groups, glucose and cortisol levels were markedly higher after hypoxia compared before hypoxia stress (P \u3c 0.05). In conclusion, dietary Guduchi can be included at 5.17–5.49 g/kg to enhance the growth performance, digestive enzyme activity, immune and antioxidative responses, and the resistance of Nile tilapia against hypoxia stress