88 research outputs found
2-Methyl-3-(2-methylphenyl)-7-nitroquinazolin-4(3H)-one
In the title methaqualone analogue, C16H13N3O3, the 2-tolyl group is almost orthogonal [dihedral angle = 85.20 (5)°] to the fused ring system (r.m.s. deviation of fitted non-H atoms = 0.029 Å). In the crystal, twofold symmetry generates two-molecule aggregates linked by C—H⋯O and π–π interactions [ring centroid–centroid distance = 3.4967 (6) Å]
2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl 4-methylbenzoate
In the title quinazolin-4-one derivative, C24H20N2O3, both the 4-methylbenzoate [dihedral angle = 83.90 (9)°] and 2-tolyl [87.88 (9)°] groups are almost orthogonal to the central fused ring system. These aryl groups are oriented towards the quinazolin-4-one-bound methyl group. In the crystal, molecules are connected into a three-dimensional architecture by C—H⋯O, C—H⋯π and π–π [ring centroid-to-centroid separation = 3.6458 (13) Å] interactions
2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl 4-bromobenzene-1-sulfonate
The title molecule, C22H17BrN2O4S, has a twisted U shape, the dihedral angle between the quinazolin-4-one and bromobenzene ring systems being 46.25 (8)°. In order to avoid steric clashes with adjacent substituents on the quinazolin-4-one ring, the N-bound tolyl group occupies an orthogonal position [dihedral angle = 89.59 (8)°]. In the crystal, molecules are connected into a three-dimensional architecture by C—H⋯O interactions, with the ketone O atom accepting two such bonds and a sulfonate O atom one
2-(4-Methoxyphenyl)-4-oxo-4-phenylbutanenitrile
The title molecule, C17H15NO2, is twisted, the dihedral angle between the terminal benzene rings being 63.30 (6)°. In the crystal, C—H⋯O and C—H⋯N interactions lead to supramolecular layers in the ab plane. These are connected along the c axis via C—H⋯π interactions
Investigation of arenesulfonyl-2-imidazolidinones as potent carbonic anhydrase inhibitors
Deanship of Scientific Research at King Saud University [RGP-VPP-163
6-Methyl-3-phenyl-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
The title compound, C15H12N2OS, exists as the thione tautomer in the solid state. The phenyl group is almost perpendicular [dihedral angle = 87.96 (5)°] to the fused ring system (r.m.s. deviation = 0.036 Å for 13 ring and exocyclic non-H atoms). In the crystal, centrosymmetric dimers, sustained by pairs of N—H⋯S hydrogen bonds, are connected into layers parallel to (-101) by C—H⋯O and C—H⋯S interactions
8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
In the title methaqualone analogue, C23H20N2O2, the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)°] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = 0.028 Å), forming dihedral angles of 86.9 (3) (with the 2-tolyl ring) and 65.57 (7)°. The 2-tolyl residue is disordered over two almost coplanar but opposite orientations with the major component having a site-occupancy factor of 0.893 (3). The three-dimensional crystal packing is consolidated by C—H⋯O, C—H⋯π and π–π [2-tolyl–2-tolyl centroid–centroid distance = 3.8099 (6) Å] interactions
2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl thiophene-2-carboxylate
In the title compound, C21H16N2O3S, the central quinazolin-4-one ring is planar (r.m.s. deviation = 0.037 Å). The N-bound benzene and thiophenyl rings are almost perpendicular to the central plane [dihedral angles = 82.22 (5) and 77.05 (13)°, respectively]. Molecules are connected into a three-dimensional array by C—H⋯O interactions involving both carbonyl O atoms. The thiophene ring is disordered over two positions, which are approximately parallel and oppositely orientated. The major component refined to a site-occupancy factor of 0.6555 (17)
4-Oxo-2,4-diphenylbutanenitrile
The title molecule, C16H13NO, is twisted, the dihedral angle between the terminal phenyl rings being 68.40 (6)°. In the crystal, C—H⋯O and C—H⋯N interactions lead to supramolecular layers in the bc plane
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