9 research outputs found
DehydromicroscleroderminB and MicroscleroderminJ: Total synthesis and structural revision
The total synthesis of dehydromicroscleroderminB and microscleroderminJ is described. Efficient approaches to the unusual amino acids in the target molecules were developed on the basis of a Negishi coupling (for Trp-2-CO2H) and Blaise reaction (for Pyrr). An incorrect assignment of the pyrrolidinone stereochemistry of both compounds was confirmed by synthesizing epimers of the proposed structures. The spectroscopic data of these epimers were in complete agreement with those for the naturally derived material
DehydromicroscleroderminB and MicroscleroderminJ: Total synthesis and structural revision
The total synthesis of dehydromicroscleroderminB and microscleroderminJ is described. Efficient approaches to the unusual amino acids in the target molecules were developed on the basis of a Negishi coupling (for Trp-2-CO2H) and Blaise reaction (for Pyrr). An incorrect assignment of the pyrrolidinone stereochemistry of both compounds was confirmed by synthesizing epimers of the proposed structures. The spectroscopic data of these epimers were in complete agreement with those for the naturally derived material
Directing Group Enhanced Carbonylative Ring Expansions of Amino-Substituted Cyclopropanes: Rhodium-Catalyzed Multicomponent Synthesis of N‑Heterobicyclic Enones
Aminocyclopropanes equipped with
suitable N-directing groups undergo
efficient and regioselective Rh-catalyzed carbonylative C–C
bond activation. Trapping of the resultant metallacycles with tethered
alkynes provides an atom-economic entry to diverse N-heterobicyclic
enones. These studies provide a blueprint for myriad N-heterocyclic
methodologies
Directing Group Enhanced Carbonylative Ring Expansions of Amino-Substituted Cyclopropanes: Rhodium-Catalyzed Multicomponent Synthesis of N‑Heterobicyclic Enones
Aminocyclopropanes equipped with
suitable N-directing groups undergo
efficient and regioselective Rh-catalyzed carbonylative C–C
bond activation. Trapping of the resultant metallacycles with tethered
alkynes provides an atom-economic entry to diverse N-heterobicyclic
enones. These studies provide a blueprint for myriad N-heterocyclic
methodologies
Tethered Aminohydroxylation: Synthesis of the β‑Amino Acid of Microsclerodermins A and B
The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain <i>via</i> a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins
Tethered Aminohydroxylation: Synthesis of the β‑Amino Acid of Microsclerodermins A and B
The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain <i>via</i> a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins