254 research outputs found
Numerical investigation of the conditioning for plane wave discontinuous Galerkin methods
We present a numerical study to investigate the conditioning of the plane
wave discontinuous Galerkin discretization of the Helmholtz problem. We provide
empirical evidence that the spectral condition number of the plane wave basis
on a single element depends algebraically on the mesh size and the wave number,
and exponentially on the number of plane wave directions; we also test its
dependence on the element shape. We show that the conditioning of the global
system can be improved by orthogonalization of the local basis functions with
the modified Gram-Schmidt algorithm, which results in significantly fewer GMRES
iterations for solving the discrete problem iteratively.Comment: Submitted as a conference proceeding; minor revisio
PathVisio Analysis: An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma
MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and progression of cancer, including osteosarcoma. We aimed to clarify the pathways involving miRNAs using new bioinformatics tools. We applied WikiPathways and PathVisio, two open-source platforms, to analyze miRNAs in osteosarcoma using miRTar and ONCO.IO as integration tools. We found 1298 records of osteosarcoma papers associated with the word "miRNA". In osteosarcoma patients with good response to chemotherapy, miR-92a, miR- 99b, miR-193a-5p, and miR-422a expression is increased, while miR-132 is decreased. All identified miRNAs seem to be centered on the TP53 network. This is the first application of PathVisio to determine miRNA pathways in osteosarcoma. MiRNAs have the potential to become a useful diagnostic and prognostic tool in the management of osteosarcoma. PathVisio is a full pathway editor with the potentiality to illustrate the biological events, augment graphical elements, and elucidate all the physical structures and interactions with standard external database identifiers
Hitting Time of Quantum Walks with Perturbation
The hitting time is the required minimum time for a Markov chain-based walk
(classical or quantum) to reach a target state in the state space. We
investigate the effect of the perturbation on the hitting time of a quantum
walk. We obtain an upper bound for the perturbed quantum walk hitting time by
applying Szegedy's work and the perturbation bounds with Weyl's perturbation
theorem on classical matrix. Based on the definition of quantum hitting time
given in MNRS algorithm, we further compute the delayed perturbed hitting time
(DPHT) and delayed perturbed quantum hitting time (DPQHT). We show that the
upper bound for DPQHT is actually greater than the difference between the
square root of the upper bound for a perturbed random walk and the square root
of the lower bound for a random walk.Comment: 9 page
Finding a Hamiltonian Path in a Cube with Specified Turns is Hard
We prove the NP-completeness of finding a Hamiltonian path in an N Ă— N Ă— N cube graph with turns exactly at specified lengths along the path. This result establishes NP-completeness of Snake Cube puzzles: folding a chain of N3 unit cubes, joined at face centers (usually by a cord passing through all the cubes), into an N Ă— N Ă— N cube. Along the way, we prove a universality result that zig-zag chains (which must turn every unit) can fold into any polycube after 4 Ă— 4 Ă— 4 refinement, or into any Hamiltonian polycube after 2 Ă— 2 Ă— 2 refinement
GeNN: a code generation framework for accelerated brain simulations
Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An ongoing challenge for simulating realistic models is, however, computational speed. In this paper, we present the GeNN (GPU-enhanced Neuronal Networks) framework, which aims to facilitate the use of graphics accelerators for computational models of large-scale neuronal networks to address this challenge. GeNN is an open source library that generates code to accelerate the execution of network simulations on NVIDIA GPUs, through a flexible and extensible interface, which does not require in-depth technical knowledge from the users. We present performance benchmarks showing that 200-fold speedup compared to a single core of a CPU can be achieved for a network of one million conductance based Hodgkin-Huxley neurons but that for other models the speedup can differ.
GeNN is available for Linux, Mac OS X and Windows platforms. The source code, user manual, tutorials,
Wiki, in-depth example projects and all other related information can be found on the project website http://genn-team.github.io/genn/
Folding equilateral plane graphs
22nd International Symposium, ISAAC 2011, Yokohama, Japan, December 5-8, 2011. ProceedingsWe consider two types of folding applied to equilateral plane graph linkages. First, under continuous folding motions, we show how to reconfigure any linear equilateral tree (lying on a line) into a canonical configuration. By contrast, such reconfiguration is known to be impossible for linear (nonequilateral) trees and for (nonlinear) equilateral trees. Second, under instantaneous folding motions, we show that an equilateral plane graph has a noncrossing linear folded state if and only if it is bipartite. Not only is the equilateral constraint necessary for this result, but we show that it is strongly NP-complete to decide whether a (nonequilateral) plane graph has a linear folded state. Equivalently, we show strong NP-completeness of deciding whether an abstract metric polyhedral complex with one central vertex has a noncrossing flat folded state with a specified “outside region”. By contrast, the analogous problem for a polyhedral manifold with one central vertex (single-vertex origami) is only weakly NP-complete
CFD investigation of a complete floating offshore wind turbine
This chapter presents numerical computations for floating offshore wind turbines for a machine of 10-MW rated power. The rotors were computed using the Helicopter Multi-Block flow solver of the University of Glasgow that solves the Navier-Stokes equations in integral form using the arbitrary Lagrangian-Eulerian formulation for time-dependent domains with moving boundaries. Hydrodynamic loads on the support platform were computed using the Smoothed Particle Hydrodynamics method. This method is mesh-free, and represents the fluid by a set of discrete particles. The motion of the floating offshore wind turbine is computed using a Multi-Body Dynamic Model of rigid bodies and frictionless joints. Mooring cables are modelled as a set of springs and dampers. All solvers were validated separately before coupling, and the loosely coupled algorithm used is described in detail alongside the obtained results
A global method for coupling transport with chemistry in heterogeneous porous media
Modeling reactive transport in porous media, using a local chemical
equilibrium assumption, leads to a system of advection-diffusion PDE's coupled
with algebraic equations. When solving this coupled system, the algebraic
equations have to be solved at each grid point for each chemical species and at
each time step. This leads to a coupled non-linear system. In this paper a
global solution approach that enables to keep the software codes for transport
and chemistry distinct is proposed. The method applies the Newton-Krylov
framework to the formulation for reactive transport used in operator splitting.
The method is formulated in terms of total mobile and total fixed
concentrations and uses the chemical solver as a black box, as it only requires
that on be able to solve chemical equilibrium problems (and compute
derivatives), without having to know the solution method. An additional
advantage of the Newton-Krylov method is that the Jacobian is only needed as an
operator in a Jacobian matrix times vector product. The proposed method is
tested on the MoMaS reactive transport benchmark.Comment: Computational Geosciences (2009)
http://www.springerlink.com/content/933p55085742m203/?p=db14bb8c399b49979ba8389a3cae1b0f&pi=1
A Scalable Parallel Approach for High-Fidelity Aerostructural Analysis and Optimization
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97076/1/AIAA2012-1922.pd
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