Ions in Fluctuating Channels: Transistors Alive

Ion channels are proteins with a hole down the middle embedded in cell membranes. Membranes form insulating structures and the channels through them allow and control the movement of charged particles, spherical ions, mostly Na+, K+, Ca++, and Cl-. Membranes contain hundreds or thousands of types of channels, fluctuating between open conducting, and closed insulating states. Channels control an enormous range of biological function by opening and closing in response to specific stimuli using mechanisms that are not yet understood in physical language. Open channels conduct current of charged particles following laws of Brownian movement of charged spheres rather like the laws of electrodiffusion of quasi-particles in semiconductors. Open channels select between similar ions using a combination of electrostatic and 'crowded charge' (Lennard-Jones) forces. The specific location of atoms and the exact atomic structure of the channel protein seems much less important than certain properties of the structure, namely the volume accessible to ions and the effective density of fixed and polarization charge. There is no sign of other chemical effects like delocalization of electron orbitals between ions and the channel protein. Channels play a role in biology as important as transistors in computers, and they use rather similar physics to perform part of that role. Understanding their fluctuations awaits physical insight into the source of the variance and mathematical analysis of the coupling of the fluctuations to the other components and forces of the system.Comment: Revised version of earlier submission, as invited, refereed, and published by journa

Pair production in a strong electric field: an initial value problem in quantum field theory

We review recent achievements in the solution of the initial-value problem for quantum back-reaction in scalar and spinor QED. The problem is formulated and solved in the semiclassical mean-field approximation for a homogeneous, time-dependent electric field. Our primary motivation in examining back-reaction has to do with applications to theoretical models of production of the quark-gluon plasma, though we here address practicable solutions for back-reaction in general. We review the application of the method of adiabatic regularization to the Klein-Gordon and Dirac fields in order to renormalize the expectation value of the current and derive a finite coupled set of ordinary differential equations for the time evolution of the system. Three time scales are involved in the problem and therefore caution is needed to achieve numerical stability for this system. Several physical features, like plasma oscillations and plateaus in the current, appear in the solution. From the plateau of the electric current one can estimate the number of pairs before the onset of plasma oscillations, while the plasma oscillations themselves yield the number of particles from the plasma frequency. We compare the field-theory solution to a simple model based on a relativistic Boltzmann-Vlasov equation, with a particle production source term inferred from the Schwinger particle creation rate and a Pauli-blocking (or Bose-enhancement) factor. This model reproduces very well the time behavior of the electric field and the creation rate of charged pairs of the semiclassical calculation. It therefore provides a simple intuitive understanding of the nature of the solution since nearly all the physical features can be expressed in terms of the classical distribution function.Comment: Old paper, already published, but in an obscure journa

Ground State Spin Structure of Strongly Interacting Disordered 1D Hubbard Model

We study the influence of on-site disorder on the magnetic properties of the ground state of the infinite U 1D Hubbard model. We find that the ground state is not ferromagnetic. This is analyzed in terms of the algebraic structure of the spin dependence of the Hamiltonian. A simple explanation is derived for the 1/N periodicity in the persistent current for this model.Comment: 3 pages, no figure

Potential of liquid-methane fuel for Mach-3 commercial supersonic transports

Liquid methane fuel for commercial fixed arrow wing supersonic transport

Pair creation in transport equations using the equal-time Wigner function

Based on the equal-time Wigner function for the Klein-Gordon field, we discuss analytically the mechanism of pair creation in a classical electromagnetic field including back-reaction. It is shown that the equations of motion for the Wigner function can be reduced to a variable-frequency oscillator. The pair-creation rate results then from a calculation analogous to barrier penetration in nonrelativistic quantum mechanics. The Wigner function allows one to utilize this treatment for the formulation of an effective transport theory for the back-reaction problem with a pair-creation source term including Bose enhancement.Comment: 19 pages, LaTeX, UFTP 316/199

The nucleus as a fluid of skyrmions: Energy levels and nucleon properties in the medium

A model of a fluid of skyrmions coupled to a scalar and to the \o meson mean fields is developed. The central and spin-orbit potentials of a skyrmion generated by the fields predict correct energy levels in selected closed shell nuclei. The effect of the meson fields on the properties of skyrmions in nuclei is investigated.Comment: Latex format, 6 figures, Journal of Physics G, to be publishe

Evaluation of functions on microcomputers: rational approximation of kth roots

AbstractThis paper describes the implementation of rational approximation algorithms for evaluation of kth roots in short wordlength machines. The emphasis is on maintaining full machine precision in computers that use fixed point, truncated binary arithmetic with at most 16 bits of wordlength. Included is a table of coefficients for evaluation of kth roots on a 16 bit machine with 3 ≤ k ≤ 11