1 research outputs found
Ca<sup>2+</sup>-Signal Transduction Inhibitors, Kujiol A and Kujigamberol B, Isolated from Kuji Amber Using a Mutant Yeast
A podocarpatriene and a labdatriene
derivative, named kujiol A
[13-methyl-8,11,13-podocarpatrien-19-ol (<b>1</b>)] and kujigamberol
B [15,20-dinor-5,7,9-labdatrien-13-ol (<b>2</b>)], respectively,
were isolated from Kuji amber through detection with the aid of their
growth-restoring activity against a mutant yeast strain (<i>zds1</i>Δ <i>erg3</i>Δ <i>pdr1</i>Δ <i>pdr3</i>Δ), which is known to be hypersensitive with respect
to Ca<sup>2+</sup>-signal transduction. The structures were elucidated
by spectroscopic data analysis. Compounds <b>1</b> and <b>2</b> are rare organic compounds from Late Cretaceous amber, and
the mutant yeast used seems useful for elucidating a variety of new
compounds from Kuji amber specimens, produced before the K–Pg
boundary