81 research outputs found
Reaction mechanism and characteristics of T_{20} in d + ^3He backward elastic scattering at intermediate energies
For backward elastic scattering of deuterons by ^3He, cross sections \sigma
and tensor analyzing power T_{20} are measured at E_d=140-270 MeV. The data are
analyzed by the PWIA and by the general formula which includes virtual
excitations of other channels, with the assumption of the proton transfer from
^3He to the deuteron. Using ^3He wave functions calculated by the Faddeev
equation, the PWIA describes global features of the experimental data, while
the virtual excitation effects are important for quantitative fits to the
T_{20} data. Theoretical predictions on T_{20}, K_y^y (polarization transfer
coefficient) and C_{yy} (spin correlation coefficient) are provided up to GeV
energies.Comment: REVTEX+epsfig, 17 pages including 6 eps figs, to be published in
Phys. Rev.
Current perspectives on bone metastases in castrate-resistant prostate cancer
Prostate cancer is the most frequent noncutaneous cancer occurring in men. On average, men with localized prostate cancer have
a high 10-year survival rate, and many can be cured. However, men with metastatic castrate-resistant prostate cancer have
incurable disease with poor survival despite intensive therapy. This unmet need has led to recent advances in therapy aimed at
treating bone metastases resulting from prostate cancer. The bone microenvironment lends itself to metastases in castrate-resistant
prostate cancer, as a result of complex interactions between the microenvironment and tumor cells. The development of 223radium
dichloride (Ra-223) to treat symptomatic bone metastases has improved survival in men with metastatic castrate-resistant
prostate cancer. Moreover, Ra-223 may have effects on the tumor microenvironment that enhance its activity. Ra-223 treatment
has been shown to prolong survival, and its effects on the immune system are under investigation. Because prostate cancer affects
a sizable portion of the adult male population, understanding how it metastasizes to bone is an important step in advancing
therapy. Clinical trials that are underway should yield new information on whether Ra-223 synergizes effectively with immunotherapy
agents and whether Ra-223 has enhancing effects on the immune system in patients with prostate cancer
Direct Observation of the Myosin Va Recovery Stroke That Contributes to Unidirectional Stepping along Actin
Myosins are ATP-driven linear molecular motors that work as cellular force
generators, transporters, and force sensors. These functions are driven by
large-scale nucleotide-dependent conformational changes, termed
âstrokesâ; the âpower strokeâ is the force-generating
swinging of the myosin light chainâbinding âneckâ domain
relative to the motor domain âheadâ while bound to actin; the
ârecovery strokeâ is the necessary initial motion that primes, or
âcocks,â myosin while detached from actin. Myosin Va is a processive
dimer that steps unidirectionally along actin following a âhand over
handâ mechanism in which the trailing head detaches and steps forward
âŒ72 nm. Despite large rotational Brownian motion of the detached head about
a free joint adjoining the two necks, unidirectional stepping is achieved, in
part by the power stroke of the attached head that moves the joint forward.
However, the power stroke alone cannot fully account for preferential forward
site binding since the orientation and angle stability of the detached head,
which is determined by the properties of the recovery stroke, dictate actin
binding site accessibility. Here, we directly observe the recovery stroke
dynamics and fluctuations of myosin Va using a novel, transient caged
ATP-controlling system that maintains constant ATP levels through stepwise
UV-pulse sequences of varying intensity. We immobilized the neck of monomeric
myosin Va on a surface and observed real time motions of bead(s) attached
site-specifically to the head. ATP induces a transient swing of the neck to the
post-recovery stroke conformation, where it remains for âŒ40 s, until ATP
hydrolysis products are released. Angle distributions indicate that the
post-recovery stroke conformation is stabilized by â„5
kBT of energy. The high kinetic
and energetic stability of the post-recovery stroke conformation favors
preferential binding of the detached head to a forward site 72 nm away. Thus,
the recovery stroke contributes to unidirectional stepping of myosin Va
PUBLIC SECTOR PAY AND REGIONAL COMPETITIVENESS. A FIRST LOOK AT REGIONAL PUBLIC?PRIVATE WAGE DIFFERENTIALS IN ITALY
Gendering the careers of young professionals: some early findings from a longitudinal study. in Organizing/theorizing: developments in organization theory and practice
Wonders whether companies actually have employees best interests at heart across physical, mental and spiritual spheres. Posits that most organizations ignore their workforce â not even, in many cases, describing workers as assets! Describes many studies to back up this claim in theis work based on the 2002 Employment Research Unit Annual Conference, in Cardiff, Wales
Effect of light, food additives and heat on the stability of sorghum 3-deoxyanthocyanins in model beverages.
This work aimed to evaluate the stability of sorghum 3-deoxyanthocyanins (DXA) in model beverages (pH 3.5) elaborated with crude sorghum phenolic extract, containing ascorbic acid and sulphite, under fluorescent light exposure and subjected to heat treatment. There was no significant difference in the DXA degradation during storage under light exposure (24.16%) and absence of light (20.72%). DXA degradation did not differ in the presence of ascorbic acid during storage under light exposure (23.99-25.38%) and absence of light (19.87-21.74%). The addition of sulphite caused an initial bleaching reaction, but as a reversible reaction, the anthocyanin content was higher on the last day of storage compared to the first day. There were no significant differences in total anthocyanin content of all treatments subjected to the heat treatment (80 °C for 5 and 25 min). Thus, crude DXA are very stable under light, additives and heat, and may be useful as natural food colourants
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