The Effect of Omega-3 Fatty Acids on the treatment of Nonalcoholic fatty liver disease in pediatric patients: A Systematic Review

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in children. Although, lifestyle modification is recommended as first-line approach in the management of pediatric NAFLD, there are inconclusive results about the efficacy of omega-3 fatty acids in the improvement of liver steatosis and the possible role of omega-3 fatty acids in the treatment of pediatric NAFLD

The effect of Vitamin E supplementation in the treatment of paediatric non-alcoholic fatty liver disease (NAFLD): A systematic review

Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a common cause of pediatric chronic liver disease. Despite advances in managing pediatric NAFLD with diet management and weight loss, evidence are lacking regarding effective pharmacological treatment2. In this study we will collect and extract data comparing the effect of vitamin E as a monotherapy or as a combination therapy with non-active (e.g. placebo) interventions

Anthropometric and baseline characteristics in children with NAFLD: A systematic review and a meta-analysis

Non Alcoholic fatty liver disease (NAFLD) is a common disease in children, resulting from excessive fat accumulation in the liver. The definition of NAFLD includes a wide spectrum of disorders such as simple steatosis, steatohepatitis and even liver cirrhosis. In this study we will investigate anthropometric characteristics, liver enzymes and lipid profile in children with NAFLD in comparison to healthy children without NAFLD

The Effect of Probiotics on the treatment of Non Alcoholic Fatty Liver Disease in pediatric patients: A Systematic Review and Meta-analysis

Non alcoholic fatty liver disease (NAFLD) is the most common liver disease affecting up to 13% of the general pediatric population and up to 80% of obese children. According to the histologic findings, NAFLD is defined as histologic evidence of at least 5% of hepatic steatosis in the absence of other comorbidities that lead to excessive fat accumulation. While weight loss and diet have been proposed as methods of liver fat reduction, these strategies may be difficult to sustain over a long-term period, while evidence are lacking regarding effective pharmacological treatment. In this study we will collect and extract data to compare the effect of Probiotics as a monotherapy or as a combination therapy with non-active (e.g. placebo) interventions

Comparative efficacy of medication and dietary supplements on the treatment of non-alcoholic fatty liver disease in pediatric patients: A systematic review and network meta-analysis

What is the most effective pharmacological or dietary supplement option to improve disease severity in pediatric patients with non-alcoholic fatty liver disease

Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy

Background and Objectives: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. Τhe aim was to assess differences in body composition, PhA, RMR, and related parameters in non-small-cell lung cancer (NSCLC) patients after treatment. Methods: The sample consisted of 82 NSCLC (stage IV) male patients (chemotherapy (C) 15.7%; immunotherapy (I) 13.3%; C + I 25.3%; (C) + radiotherapy (R) 22.9 %; and other 15.5%). Body weight and body composition, PhA, RMR, oxygen consumption (VO2), ventilation rate, and diet were assessed at baseline and at 3 months after initiation of therapy. Results: Reductions in PhA, RMR, VO2, ventilation rate, and intracellular water were observed at follow up. Weight loss was evident for 45% of patients who also had a reduction in lean body mass. In the group under C, lean mass was reduced at follow up (55.3 ± 11.53 vs. 52.4 ± 12.6, p = 0.04) without significant weight changes. In subjects with a low adherence to the Mediterranean diet (MedDietScore p = 0.001), VO2 (277.1 ± 70.2 vs. 247 ± 49.1 mL/min, p = 0.001), and ventilation rate (10.1 ± 2.28 vs. 9. ± 2 2.2 L/min, p = 0.03) were significantly reduced. The changes in body weight were positively related to % of change in fat mass (rho = 0.322, p = 0.003) and absolute lean mass change (rho = 0.534, p p = 0.004) (Spearman correlation coefficients). Conclusions: In conclusion, cancer therapy related to reductions in PhA and RMR, while lean mass reduction may be related to the type of treatment. Our results emphasize the importance of a more holistic nutritional and body composition assessment beyond body weight, to better address patients’ needs in clinical practice