A new facility for viscosity and density measurements for CO2 – rich mixtures relevant for CO2 transport and storage

For safe and cost-effective design, optimization, and operation of CO2 capture, transport, and storage (CCS) processes, accurate viscosity and density data of CO2-rich mixtures are required. Currently, there are large knowledge gaps in these properties, and it needs to be addressed for building good reservoir models and simulation tools. A modified two-capillary viscometer with several novel solutions for accurate measurement of viscosity and density of CO2-rich mixtures relevant for CO2 transport and storage has been designed and constructed. The new setup covers a range between 213.15 K and 423.15 K in temperature and up to 100 MPa in pressure. This paper describes the facility, calibrations, uncertainties estimation, and first test measurements performed using the setuppublishedVersio

Forstudie: CCS i Midt-Norge

publishedVersio

Forstudie: CCS i Midt-Norge

publishedVersio

A New Facility on Accurate Viscosity and Density Measurements

A new facility for accurate measurement of viscosity and density of CO2-rich mixtures relevant for CO2 Capture and Storage (CCS) has been constructed. The facility includes a two-capillary viscometer with several novel solutions to enable high performance over a range between 213.15 K and 473.15 K (-60 and 200 °C) in temperature and up to 100 MPa (1000 bar) in pressure. There are currently very little data available on viscosity of liquid CO2-rich mixtures relevant for CCS, needed for instance in simulations of injection processes and reservoirs. Integrated in the setup is also a densimeter which is controlled to the same temperatures and pressures. Apart from providing density data, this enables accurate conversion between kinematic and dynamic viscosity. The total uncertainty target of the facility is 0.1 % (95% confidence level), except close to the critical point

Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery

Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid drug clearance from the peritoneal cavity is a major challenge. Aiming to delay drug absorption and reduce toxic side effects, cabazitaxel (CAB)-loaded poly(alkyl cyanoacrylate) (PACA) nanoparticles were encapsulated in alginate microspheres. The PACAlg alginate microspheres were synthesized by electrostatic droplet generation and the physicochemical properties, stability, drug release kinetics, and mesothelial cytotoxicity were analyzed before biodistribution and therapeutic efficacy were studied in mice. The 450 µm microspheres were stable at in vivo conditions for at least 21 days after intraperitoneal implantation in mice, and distributed evenly throughout the peritoneal cavity without aggregation or adhesion. The nanoparticles were stably retained in the alginate microspheres, and nanoparticle toxicity to mesothelial cells was reduced, while the therapeutic efficacy of free CAB was maintained or improved in vivo. Altogether, this work presents the alginate encapsulation of drug-loaded nanoparticles as a promising novel strategy for the treatment of peritoneal metastasis that can improve the therapeutic ratio between toxicity and therapeutic efficacy.publishedVersio