Results of multiple stepwise regression analysis for independence of factors contributing to ONH MBR.

<p>Results of multiple stepwise regression analysis for independence of factors contributing to ONH MBR.</p

Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.

<p>Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.</p

Results of multiple stepwise regression analysis for independence of factors contributing to choroidal MBR.

<p>Results of multiple stepwise regression analysis for independence of factors contributing to choroidal MBR.</p

Relationship between best-corrected visual acuity (BCVA), optic nerve head (ONH), and choroid mean blur rate (MBR).

<p>The BCVA correlated with ONH MBR in the vessel (<i>r</i> = −0.386, <i>p</i> < 0.001), in the tissue (<i>r</i> = −0.348, <i>p</i> < 0.001), and choroidal MBR (<i>r</i> = −0.339, <i>p</i> = 0.002). AU = arbitrary units.</p

Clinical characteristics of subjects.

<p>Clinical characteristics of subjects.</p

Differences between the eyes of normal subjects and those of patients with severe non-proliferative diabetic retinopathy (S-NPDR) in terms of mean blur rate (MBR) as determined by laser speckle flowgraphy (LSFG).

<p>The MBR of the optic nerve head (ONH) in the vessel and the tissue in the S-NPDR with panretinal photocoagulation (PRP) group was significantly lower than that in the S-NPDR without PRP and normal subjects groups (A) (B) (<i>p</i> < 0.001, <i>p</i> < 0.001, respectively). The choroidal MBR in the S-NPDR with PRP group was significantly lower than that in the S-NPDR without PRP and the normal subjects groups (<i>p</i> = 0.028, <i>p</i> < 0.001).</p

Differences between the eyes of normal subjects and those of patients with severe non-proliferative diabetic retinopathy (S-NPDR) with regard to subfoveal choroidal area as determined by binarization.

<p>The choroidal (A), luminal (B), and stromal area (C) in the S-NPDR with panretinal photocoagulation (PRP) group were significantly smaller than that in the S-NPDR without PRP and the normal subjects groups (<i>p</i> < 0.001, <i>p</i> < 0.001, <i>p</i> < 0.001, respectively). The luminal/stromal ratio in the S-NPDR with PRP group was significantly smaller than that in the S-NPDR without PRP and the normal subjects groups (<i>p</i> < 0.001, <i>p</i> < 0.001, respectively).</p

Representative composite color maps reflecting the mean blur rate (MBR) as measured by laser speckle flowgraphy (LSFG).

<p>Red color indicates a high MBR, and blue color indicates a low MBR. To measure the MBR of the optic nerve head (ONH) blood flow and choroidal blood, a circle was set around the ONH (left) and the center of a rectangle was set at the fovea (250 × 250 pixels, degree: 6.31° × 6.31°) (right). Eyes of i) normal subjects (A, B), ii) severe non-proliferative diabetic retinopathy (S-NPDR) patients without panretinal photocoagulation (PRP) (C, D), and iii) S-NPDR patients with PRP (E, F) are demonstrated. The blue color is dominant in the ONH and choroid in S-NPDR patient eyes with PRP (E, F).</p

Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.

<p>Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.</p

Changes in mean EZ–RPE thickness following surgery, and the correlation between the thickness and the BCVA is shown for eyes with macula-off RRD.

<p>The mean EZ-RPE thickness increases significantly over time (<i>P</i> < 0.001), and it is especially rapid in the early postoperative period (A). The EZ-RPE thicknesses at Week 2 and Month 12 were significantly correlated with the BCVA at Week 2 (<i>r</i> = -0.48, <i>P</i> = 0.008) (B) and at Month 12 (<i>r</i> = -0.68, <i>P</i> < 0.001) (C), respectively. The EZ-RPE thickness at Week 2 was significantly correlated with the BCVA at Month 12 (<i>r</i> = -0.40, <i>P</i> = 0.036) (D). The foveal outer nuclear layer (ONL) thickness at Month 12 was not correlated with the BCVA at Month 12 (E).</p