Demographic characteristics of the study population.

<p>Demographic characteristics of the study population.</p

Mean complement activities and concentrations in chronic central serous chorioretinopathy (CSC) patients and controls.

<p>Mean complement activities and concentrations in chronic central serous chorioretinopathy (CSC) patients and controls.</p

Median C3d/C3 ratios for non-genetic factors.

<p>IQR  =  interquartile range (1^st quartile – 3^rd quartile).</p

Logarithmic C3d/C3 ratios for haplotypes in the <i>CFB</i> gene rs4151667 and rs641153.

<p>Logarithmic C3d/C3 ratios for haplotypes in the <i>CFB</i> gene rs4151667 and rs641153.</p

Median C3d/C3 ratios for single nucleotid polymorphisms (SNPs).

<p>*Due to small number of cases excluded from univariate ANOVA analysis; IQR  =  interquartile range (1^st quartile – 3^rd quartile).</p

Logarithmic C3d/C3 ratios for haplotypes in the <i>CFH</i> gene rs1061170, rs800292 and rs12144939.

<p>Logarithmic C3d/C3 ratios for haplotypes in the <i>CFH</i> gene rs1061170, rs800292 and rs12144939.</p

Haplotypes for <i>CFH/CFB</i> and median C3d/C3 ratios.

<p>For CFH single nucleotides polymorphisms rs1061170, rs800292, and rs12144939 and for CFB rs4151667 and rs641153 were chosen.</p><p>*T- test with comparison to reference haplotypes TGG and TG; **Due to small number of cases excluded from analysis; IQR  =  interquartile range (1^st quartile – 3^rd quartile).</p

Logistic regression analysis between AMD and single nucleotide polymorphisms SNPs⁺.

+<p>Adjusted for age and gender; *analysis not performed due to small group size.</p

Recurrent missense variants identified in two of 289 candidate genes in 12 sporadic CD subtype of AMD cases by WES.

<p>Recurrent missense variants identified in two of 289 candidate genes in 12 sporadic CD subtype of AMD cases by WES.</p

Segregation analysis of rare sequence variants identified in candidate genes in cuticular drusen (CD) families by whole exome sequencing (WES).

<p>Circles, females; squares, males; empty symbols, unaffected; black symbols, affected; asterisks, exome sequenced individuals; ‘+’ symbol, wild type allele; ‘m’ symbol, mutant type allele. The age at participation is specified below the symbols.</p