Concomitant administration of radiation with eribulin improves the survival of mice harboring intracerebral glioblastoma

Glioblastoma is the most common and devastating type of malignant brain tumor. We recently found that eribulin suppresses glioma growth in vitro and in vivo and that eribulin is efficiently transferred into mouse brain tumors at a high concentration. Eribulin is a non‐taxane microtubule inhibitor approved for breast cancer and liposarcoma. Cells arrested in M‐phase by chemotherapeutic agents such as microtubule inhibitors are highly sensitive to radiation‐induced DNA damage. Several recent case reports have demonstrated the clinical benefits of eribulin combined with radiation therapy for metastatic brain tumors. In this study, we investigated the efficacy of a combined eribulin and radiation treatment on human glioblastoma cells. The glioblastoma cell lines U87MG, U251MG and U118MG, and SJ28 cells, a patient‐derived sphere culture cell line, were used to determine the radiosensitizing effect of eribulin using western blotting, flow cytometry and clonogenic assay. Subcutaneous and intracerebral glioma xenografts were generated in mice to assess the efficacy of the combined treatment. The combination of eribulin and radiation enhanced DNA damage in vitro. The clonogenic assay of U87MG demonstrated the radiosensitizing effect of eribulin. The concomitant eribulin and radiation treatment significantly prolonged the survival of mice harboring intracerebral glioma xenografts compared with eribulin or radiation alone (P < .0001). In addition, maintenance administration of eribulin after the concomitant treatment further controlled brain tumor growth. Aberrant microvasculature was decreased in these tumors. Concomitant treatment with eribulin and radiation followed by maintenance administration of eribulin may serve as a novel therapeutic strategy for glioblastomas

Adsorption of carboxylate ions by magnesium-aluminium oxide : formation of layered hydrotalcite-like compounds

The adsorption behavior and isotherms of various saturated aliphatic carbo-xvlate ions [c(m)H(2m+1) COO ; m=1-4, C(n)H(2n) (COO)₂; n=0-4) by the magnesium-aluminium oxide, Mg* (0,68)A1 0,32 ( vacancy) » prepared by the thermal decomposition of a synthetic hydro- talcite were investigated at 25 °C. The oxide was found to adsorb highly carboxylate ions to reconstruct the hydrotalcite-type structure with the Freundlich isotherm applicable in all cases. The values of Freundlich' s constants for dicarboxylate ions were much higher than those of monocarboxylate ions. The interlayer distance and the degree of crystallinity of the solid products diversely varied with the adsorbed amount and the numbers of carboxyl group and total carbon of the guest anions.Narita Eiichi, Yamagishi Toshihide. Adsorption of carboxylate ions by magnesium-aluminium oxide : formation of layered hydrotalcite-like compounds. In: Proceedings of the 9th international Clay Conference, Strasbourg, 1989. Vol II : Surface chemistry. Structure and mixed layering of clays. Strasbourg : Institut de Géologie – Université Louis-Pasteur, 1990. pp. 145-154. (Sciences Géologiques. Mémoire, 86

Adsorption of carboxylate ions by magnesium-aluminium oxide : formation of layered hydrotalcite-like compounds

The adsorption behavior and isotherms of various saturated aliphatic carbo-xvlate ions [c(m)H(2m+1) COO ; m=1-4, C(n)H(2n) (COO)₂; n=0-4) by the magnesium-aluminium oxide, Mg* (0,68)A1 0,32 ( vacancy) » prepared by the thermal decomposition of a synthetic hydro- talcite were investigated at 25 °C. The oxide was found to adsorb highly carboxylate ions to reconstruct the hydrotalcite-type structure with the Freundlich isotherm applicable in all cases. The values of Freundlich' s constants for dicarboxylate ions were much higher than those of monocarboxylate ions. The interlayer distance and the degree of crystallinity of the solid products diversely varied with the adsorbed amount and the numbers of carboxyl group and total carbon of the guest anions.Narita Eiichi, Yamagishi Toshihide. Adsorption of carboxylate ions by magnesium-aluminium oxide : formation of layered hydrotalcite-like compounds. In: Proceedings of the 9th international Clay Conference, Strasbourg, 1989. Vol II : Surface chemistry. Structure and mixed layering of clays. Strasbourg : Institut de Géologie – Université Louis-Pasteur, 1990. pp. 145-154. (Sciences Géologiques. Mémoire, 86