27 research outputs found
Recommended from our members
Enkephalin and other peptides reduce passiveness
Enkephalin and other brain peptides previously have been shown to be active in the dopa potentiation test which may be considered an animal model of mental depression. A recently described model of passive immobility during swimming, also sensitive to tricyclic antidepressants, was therefore used to study a large number of naturally occurring peptides and some of their analogues. It was found that several enkephalins with no opiate activity after peripheral injection reduced the immobility and thus increased the activity of swimming rats. α-MSH, but not its 4–10 core or a 4–9 analogue, also caused significantly more swimming than did the diluent control. As we have previously found in several animal and clinical studies, a smaller dose of MIF-I was more effective than larger doses. The results confirm our concept of the CNS actions of brain peptides and support the suggestion that some of them, like the enkephalins, might be useful after peripheral administration in mental depression or other CNS disorders
New Orleans and Hurricane Katrina. II: The Central Region and the Lower Ninth Ward
The failure of the New Orleans regional flood protection systems, and the resultant catastrophic flooding of much of New Orleans during Hurricane Katrina, represents the most costly failure of an engineered system in U.S. history. This paper presents an overview of the principal events that unfolded in the central portion of the New Orleans metropolitan region during this hurricane, and addresses the levee failures and breaches that occurred along the east-west trending section of the shared Gulf Intracoastal Waterway/Mississippi River Gulf Outlet channel, and along the Inner Harbor Navigation Channel, that affected the New Orleans East, the St. Bernard Parish, and the Lower Ninth Ward protected basins. The emphasis in this paper is on geotechnical lessons, and also broader lessons with regard to the design, implementation, operation, and maintenance of major flood protection systems. Significant lessons learned here in the central region include: (1) the need for regional-scale flood protection systems to perform as systems, with the various components meshing well together in a mutually complementary manner; (2) the importance of considering all potential failure modes in the engineering design and evaluation of these complex systems; and (3) the problems inherent in the construction of major regional systems over extended periods of multiple decades. These are important lessons, as they are applicable to other regional flood protection systems in other areas of the United States, and throughout much of the world
New Orleans and Hurricane Katrina. I: Introduction, Overview, and the East Flank
The failure of the New Orleans regional flood protection systems, and the resultant catastrophic flooding of much of New Orleans during Hurricane Katrina, represents the most costly failure of an engineered system in U.S. history. This paper presents an overview of the principal events that unfolded during this catastrophic hurricane, and then a more detailed look at the early stages of the event as the storm first drove onshore and then began to pass to the east of the main populated areas. The emphasis in this paper is on geotechnical lessons and it also includes broader lessons with regard to the design, implementation, operation, and maintenance of major flood protection systems. This paper focuses principally on the early stages of this disaster, including the initial inundation of Plaquemines Parish along the lower reaches of the Mississippi River as Katrina made landfall, and the subsequent additional early levee breaches and erosion along the eastern flanks of the regional flood protection systems fronting Lake Borgne that resulted in the flooding of the two large protected basins of New Orleans East and St. Bernard Parish. Significant lessons learned include (1) the need for realistic assessment of risk exposure as an element of flood protection policy; (2) the importance of considering erodibility of embankment and foundation soils in levee design and construction; (3) the importance of considering all potential failure modes; and (4) the problems inherent in the construction of major regional systems over extended periods of multiple decades. These are important lessons, as they are applicable to other regional flood protection systems in other areas of the United States, and throughout much of the world