System Specifications and Flow Control

We started with an approach intended for the formalization of software/hardware interactions in distributed systems and applied it to an elevator control problem. The emphasis on physical relevance, intrinsic to the approach, has resulted in a new treatment of the elevator problem, one which reflects faithfully the structural and behavioral properties of the system components and which allows the designer to work on the algorithm for elevator movement and its proof in the realistic context of the total system. In addition to presenting the model we discuss several issues important in ensuring the physical relevance of software specifications: (1) boundary validation, (2) failure analysis, and (3) design-rules formulation and enforcement

A Shared Dataspace Language Supporting Larger-Scale Concurrency

Our ultimate goal is to develop the software support needed for the design, analysis, understanding, and testing of programs involving many thousands of concurrent processes running on a highly parallel multiprocessor. We are currently evaluating the use of a shared dataspace paradigm as the basis for a new programming language supporting large-scale concurrency. The language is called SDL (Shared Dataspace Language). In SDL, a content-addressable dataspace is examined and altered by concurrent processes using atomic transactions much like those in a traditional database. Associated with each process is a programmer-defined view. The view is a mechanism which allows processes to interrogate the dataspace at a level of abstraction convenient for the task they are pursuing. This paper provides an overview of the key SDL features. Small examples are used to illustrate the power and flexibility of the language. They also serve as a backdrop against which we discuss programming style implications of the shared dataspace paradigm

CTIX Message System User\u27s Manual Version 1.0

This manual describes how to use the CTIX Message System for interprocess communication in a distributed application program. The CTIX Message System is a package of message-passing facilities developed by the Concurrent Systems Group of the Department of Computer Science at Washington University, It provides a process-to-process asynchronous, buffered communication medium. The package is implemented on a network of Convergent Technologies (CT) MiniFrame workstations. These workstations support the CTIX (the Ct\u27s version of UNIX System V) operating system and the TCP/IP network protocols

Toward Comprehensive Specification of Distributed Systems

A new approach to modelling distributed systems is presented. It uses sequential processes and event synchronization as building blocks to construct a cohesive picture of the interdependent requirements for the functionality, architecture, scheduling policies, and performance attributes of a distributed system. A language called CSPS (an extension of Hoare\u27s CSP) is used in the illustration of the approach. Employing CSP as a base allows modelled systems to be verified using techniques already developed for verifying CSP programs and leads to the emergence of a uniform incremental strategy for verifying both logical and performance properties of distributed systems. Several small distributed systems have been modelled using this approach. These exercises enabled us to evaluate the notation system and to gain some expertise on how to approach the specification of distributed systems. This paper describes one of the models and the modelling strategy that has emerged from these exercises

Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis

SummaryProper growth of dendrites is critical to the formation of neuronal circuits, but the cellular machinery that directs the addition of membrane components to generate dendritic architecture remains obscure. Here, we demonstrate that post-Golgi membrane trafficking is polarized toward longer dendrites of hippocampal pyramidal neurons in vitro and toward apical dendrites in vivo. Small Golgi outposts partition selectively into longer dendrites and are excluded from axons. In dendrites, Golgi outposts concentrate at branchpoints where they engage in post-Golgi trafficking. Within the cell body, the Golgi apparatus orients toward the longest dendrite, and this Golgi polarity precedes asymmetric dendrite growth. Manipulations that selectively block post-Golgi trafficking halt dendrite growth in developing neurons and cause a shrinkage of dendrites in mature pyramidal neurons. Further, disruption of Golgi polarity produces neurons with symmetric dendritic arbors lacking a single longest principal dendrite. These results define a novel polarized organization of neuronal secretory trafficking and demonstrate a mechanistic link between directed membrane trafficking and asymmetric dendrite growth

A Spectroscopic Survey of a Sample of Active M Dwarfs

A moderate resolution spectroscopic survey of Fleming's sample of 54 X-ray selected M dwarfs with photometric distances less than 25 pc is presented. Radial and rotation velocities have been measured by fits to the H-alpha profiles. Radial velocities have been measured by cross correlation. Artificial broadening of an observed spectrum has produced a relationship between H-alpha FWHM and rotation speed, which we use to infer rotation speeds for the entire sample by measurement of the H-alpha emission line. We find 3 ultra-fast rotators (UFRs, vsini > 100km/s), and 8 stars with 30 < vsini < 100 km/s. The UFRs have variable emission. Cross-correlation velocities measured for ultra-fast rotators (UFRs) are shown to depend on rotation speed and the filtering used. The radial velocity dispersion of the sample is 17 km/s. A new double emission line spectroscopic binary with a period of 3.55 days has been discovered, and another known one is in the sample. Three other objects are suspected spectroscopic binaries, and at least six are visual doubles. The only star in the sample observed to have significant lithium is a known TW Hya Association member, TWA 8A. These results show that there are a number of young (< 10^8 yr) and very young (< 10^7 yr) low mass stars in the immediate solar neighbourhood. The H-alpha activity strength does not depend on rotation speed. Our fast rotators are less luminous than similarly fast rotators in the Pleiades. They are either younger than the Pleiades, or gained angular momentum in a different way.Comment: 38 pages incl. 14 figures and 4 tables, plus 12 pages of table for electronic journal only; LaTeX, aastex.cls. Accepted 07/18/02 for publication in The Astronomical Journa

The Role of Rumination and Reduced Concreteness in the Maintenance of Posttraumatic Stress Disorder and Depression Following Trauma

Rumination has been linked to posttraumatic stress disorder (PTSD) and depression following trauma. A cross-sectional (N = 101) and a prospective longitudinal study (N = 147) of road traffic accident survivors assessed rumination, PTSD and depression with self-report measures and structured interviews. We tested the hypotheses that (1) rumination predicts the maintenance of PTSD and depression and (2) reduced concreteness of ruminative thinking may be a maintaining factor. Rumination significantly predicted PTSD and depression at 6 months over and above what could be predicted from initial symptom levels. In contrast to the second hypothesis, reduced concreteness in an iterative rumination task was not significantly correlated with self-reported rumination frequency, and did not consistently correlate with symptom severity measures. However, multiple regression analyses showed that the combination of reduced concreteness and self-reported frequency of rumination predicted subsequent PTSD better than rumination frequency alone. The results support the view that rumination is an important maintaining factor of trauma-related emotional disorders

Post-Newtonian Gravitational Radiation and Equations of Motion via Direct Integration of the Relaxed Einstein Equations. I. Foundations

We present a self-contained framework called Direct Integration of the Relaxed Einstein Equations (DIRE) for calculating equations of motion and gravitational radiation emission for isolated gravitating systems based on the post-Newtonian approximation. We cast the Einstein equations into their ``relaxed'' form of a flat-spacetime wave equation together with a harmonic gauge condition, and solve the equations formally as a retarded integral over the past null cone of the field point (chosen to be within the near zone when calculating equations of motion, and in the far zone when calculating gravitational radiation). The ``inner'' part of this integral(within a sphere of radius $\cal R \sim$ one gravitational wavelength) is approximated in a slow-motion expansion using standard techniques; the ``outer'' part, extending over the radiation zone, is evaluated using a null integration variable. We show generally and explicitly that all contributions to the inner integrals that depend on $\cal R$ cancel corresponding terms from the outer integrals, and that the outer integrals converge at infinity, subject only to reasonable assumptions about the past behavior of the source. The method cures defects that plagued previous ``brute-force'' slow-motion approaches to motion and gravitational radiation for isolated systems. We detail the procedure for iterating the solutions in a weak-field, slow-motion approximation, and derive expressions for the near-zone field through 3.5 post-Newtonian order in terms of Poisson-like potentials.Comment: 43 pages, RevTeX, 3 figures, submitted to Physical Review

Experimental Aspects of Synthesis

We discuss the problem of experimentally evaluating linear-time temporal logic (LTL) synthesis tools for reactive systems. We first survey previous such work for the currently publicly available synthesis tools, and then draw conclusions by deriving useful schemes for future such evaluations. In particular, we explain why previous tools have incompatible scopes and semantics and provide a framework that reduces the impact of this problem for future experimental comparisons of such tools. Furthermore, we discuss which difficulties the complex workflows that begin to appear in modern synthesis tools induce on experimental evaluations and give answers to the question how convincing such evaluations can still be performed in such a setting.Comment: In Proceedings iWIGP 2011, arXiv:1102.374

Visual impairment in an optineurin mouse model of primary open-angle glaucoma

Primary open angle glaucoma (POAG) is characterized by progressive neurodegeneration of retinal ganglion cells (RGCs). Why RGCs degenerate in low pressure POAG remains poorly understood. To gain mechanistic insights, we developed a novel mouse model based on a mutation in human optineurin associated with hereditary, low-pressure POAG. This mouse improves the design and phenotype of currently available optineurin mice, which showed high global overexpression. While both 18-month old optineurin and nontransgenic control mice showed an age-related decrease in healthy axons and RGCs, the expression of mutant optineurin enhanced axonal degeneration and decreased RGC survival. Mouse visual function was determined using visual evoked potentials, which revealed specific visual impairment in contrast sensitivity. The E50K optineurin transgenic mouse described here exhibited clinical features of POAG, and may be useful for mechanistic dissection of POAG and therapeutic development