Apolipoprotein M

Apolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL). Human apoM gene is located in p21.31 on chromosome 6 (chromosome 17, in mouse). Human apoM cDNA (734 base pairs) encodes 188-amino acid residue-long protein. It belongs to lipocalin protein superfamily. Human tissue expression array study indicates that apoM is only expressed in liver and in kidney and small amounts are found in fetal liver and kidney. In situ apoM mRNA hybridization demonstrates that apoM is exclusively expressed in the hepatocytes and in the tubule epithelial cells in kidney. Expression of apoM could be regulated by platelet activating factor (PAF), transforming growth factors (TGF), insulin-like growth factor (IGF) and leptin in vivo and/or in vitro. It has been demonstrated that apoM expression is dramatically decreased in apoA-I deficient mouse. Hepatocyte nuclear factor-1α (HNF-1α) is an activator of apoM gene promoter. Deficiency of HNF-1α mouse shows lack of apoM expression. Mutations in HNF-1α (MODY3) have reduced serum apoM levels. Expression of apoM is significantly decreased in leptin deficient (ob/ob) mouse or leptin receptor deficient (db/db) mouse. ApoM concentration in plasma is positively correlated to leptin level in obese subjects. These may suggest that apoM is related to the initiation and progression of MODY3 and/or obesity

Dissecting the spiral galaxy M83: mid-infrared emission and comparison with other tracers of star formation

We present a detailed mid-infrared study of the nearby, face-on spiral galaxy M83 based on ISOCAM data. M83 is a unique case study, since a wide variety of MIR broad-band filters as well as spectra, covering the wavelength range of 4 to 18\mu m, were observed and are presented here. Emission maxima trace the nuclear and bulge area, star-formation regions at the end of the bar, as well as the inner spiral arms. The fainter outer spiral arms and interarm regions are also evident in the MIR map. Spectral imaging of the central 3'x3' (4 kpc x 4 kpc) field allows us to investigate five regions of different environments. The various MIR components (very small grains, polycyclic aromatic hydrocarbon (PAH) molecules, ionic lines) are analyzed for different regions throughout the galaxy. In the total 4\mu m to 18\mu m wavelength range, the PAHs dominate the luminosity, contributing between 60% in the nuclear and bulge regions and 90% in the less active, interarm regions. Throughout the galaxy, the underlying continuum emission from the small grains is always a smaller contribution in the total MIR wavelength regime, peaking in the nuclear and bulge components. The implications of using broad-band filters only to characterize the mid-infrared emission of galaxies, a commonly used ISOCAM observation mode, are discussed. We present the first quantitative analysis of new H-alpha and 6cm VLA+Effelsberg radio continuum maps of M83. The distribution of the MIR emission is compared with that of the CO, HI, R band, H-alpha and 6cm radio. A striking correlation is found between the intensities in the two mid-infrared filter bands and the 6cm radio continuum. To explain the tight mid-infrared-radio correlation we propose the anchoring of magnetic field lines in the photoionized shells of gas clouds.Comment: 22 pages, 15 figures. Accepted for publication in A&

A Chandra Observation of the Diffuse Emission in the Face-on Spiral NGC 6946

This paper describes the {\it Chandra} observation of the diffuse emission in the face-on spiral NGC 6946. Overlaid on optical and H${\alpha}$ images, the diffuse emission follows the spiral structure of the galaxy. An overlay on a 6 cm polarized radio intensity map confirms the phase offset of the polarized emission. We then extract and fit the spectrum of the unresolved emission with several spectral models. All model fits show a consistent continuum thermal temperature with a mean value of 0.25$\pm$0.03 keV. Additional degrees of freedom are required to obtain a good fit and any of several models satisfy that need; one model uses a second continuum component with a temperature of 0.70$\pm$0.10 keV. An abundance measure of 3$^{+1.95}_{-1.90}$ for Si differs from the solar value at the 90% confidence level; the net diffuse spectrum shows the line lies above the instrumental Si feature. For Fe, the abundance measure of 0.67$\pm$0.13 is significant at 99%. Multiple gaussians also provide a good fit. Two of the fitted gaussians capture the O VII and O VIII emission; the fitted emission is consistent with an {\it XMM-Newton} RGS spectrum of diffuse gas in M81. The ratio of the two lines is $<$0.6-0.7 and suggests the possibility of non-equilibrium ionization conditions exist in the ISM of NGC 6946. An extrapolation of the point source luminosity distribution shows the diffuse component is not the sum of unresolved point sources; their contribution is at most 25%.Comment: accepted for ApJ; 16 pages; 12 figs; to meet Archive size limits, most converted to jpe

A Catalog of Candidate Intermediate-luminosity X-ray Objects

ROSAT, and now Chandra, X-ray images allow studies of extranuclear X-ray point sources in galaxies other than our own. X-ray observations of normal galaxies with ROSAT and Chandra have revealed that off-nuclear, compact, Intermediate-luminosity (Lx[2-10 keV] >= 1e39 erg/s) X-ray Objects (IXOs, a.k.a. ULXs [Ultraluminous X-ray sources]) are quite common. Here we present a catalog and finding charts for 87 IXOs in 54 galaxies, derived from all of the ROSAT HRI imaging data for galaxies with cz <= 5000 km/s from the Third Reference Catalog of Bright Galaxies (RC3). We have defined the cutoff Lx for IXOs so that it is well above the Eddington luminosity of a 1.4 Msun black hole (10^38.3 erg/s), so as not to confuse IXOs with ``normal'' black hole X-ray binaries. This catalog is intended to provide a baseline for follow-up work with Chandra and XMM, and with space- and ground-based survey work at wavelengths other than X-ray. We demonstrate that elliptical galaxies with IXOs have a larger number of IXOs per galaxy than non-elliptical galaxies with IXOs, and note that they are not likely to be merely high-mass X-ray binaries with beamed X-ray emission, as may be the case for IXOs in starburst galaxies. Approximately half of the IXOs with multiple observations show X-ray variability, and many (19) of the IXOs have faint optical counterparts in DSS optical B-band images. Follow-up observations of these objects should be helpful in identifying their nature.Comment: 29 pages, ApJS, accepted (catalog v2.0) (full resolution version of paper and future releases of catalog at http://www.xassist.org/ixocat_hri

Serendipitous XMM-Newton Detection of X-ray Emission from the Bipolar Planetary Nebula Hb 5

We report the serendipitous detection by the XMM-Newton X-ray Observatory of an X-ray source at the position of the Type I (He- and N-rich) bipolar planetary nebula Hb 5. The Hb 5 X-ray source appears marginally resolved. While the small number of total counts (~170) and significant off-axis angle of the X-ray source (~7.8') precludes a definitive spatial analysis, the morphology of the X-ray emission appears to trace the brightest features seen in optical images of Hb 5. The X-ray spectrum is indicative of a thermal plasma at a temperature between 2.4 and 3.7 MK and appears to display strong Neon emission. The inferred X-ray luminosity is L_X = 1.5 x 10^32 ergs/s. These results suggest that the detected X-ray emission is dominated by shock-heated gas in the bipolar nebula, although we cannot rule out the presence of a point-like component at the position of the central star. The implications for and correspondence with current models of shock-heated gas in planetary nebulae is discussed.Comment: 11 pages, 2 figures, Accepted by The Astrophysical Journa