Effets pharmacologiques d’un extrait aqueux de Bidens pilosa L. (Asteraceae) sur le système cardiovasculaire de mammifères

Pharmacological effects of an aqueous extract of Bidens pilosa L.(Asteraceae) on the cardiovascular system of mammalsThe crude aqueous extract of Bidens pilosa L. (Asteraceae), for concentrations ranging from 1x10-3 to 1.4x10-2 g/kg of body weight (b. w.) induced a transient dose dependant hypotension in the rabbit whereas the respiratory wide range and frequency were lessaffected. On the isolated heart of rat, this natural substance caused negative inotropic and chronotropic effects from the concentration of 10-10 mg/mL. These effects reached their maximum values at 10-8 mg/mL and then decreased at 10-6 mg/mL. At 10-4 mg/mL,no major changes were noticed in the recordings. These results suggest that the hypotension induced by Bidens pilosa L. could result, onthe one hand, from the relaxing effects observed by some authors on the vascular smooth muscle and on the other hand, from the cardiodepressant effects of the active principles contained in the plant.Three kinds of active principles were revealed in the presence of atropine, a muscarinic cholinoceptors antagonist. These are : 1) Muscarinic cholinomimetic active principles inhibited by atropine.2) Cardiodepressant principles insensible to atropine.3) Cardioactive principles acting at high doses of Bidens pilosa.At the dose of 1.3x10-1 g/kg of b.w., the crude extract of Bidens pilosa caused a deep hypotension followed by a respiratory arrest lethal for the rabbit. The results obtained justify the use of Bidens pilosa in traditional medicine to treat hypertension

Étude ethnobotanique et screening phytochimique de Caesalpinia benthamiana (Baill.) Herend. et Zarucchi (Caesalpiniaceae)

Les informations ethnobotaniques obtenues auprès de dix (10) tradithérapeutes du canton N\'Gadié dans le Département d\'Adzopé montrent que l\'utilisation de Caesalpinia benthamiana (Caesalpiniaceae) (Cb) contribue significativement aux soins de santé primaire pour le traitement des troubles de l\'érection. En effet, sur les quinze (15) espèces de plantes médicinales (réparties entre 14 familles) utilisées pour le traitement de diverses pathologies liées aux troubles de l\'érection, Cb est la plus fréquemment prescrite dans ledit canton. Un screening phytochimique réalisé sur cinq (5) extraits bruts des racines de Cb a révélé qu\'elles renferment des stérols, polyterpènes, flavonoïdes, saponines, tannins, sucres réducteurs, coumarines et des protéines.Ethnobotanical Informations obtained beside ten (10) traditional herbalists of the canton N\'Gadie in the Department of Adzope show that the use of Caesalpinia benthamiana(Caesalpiniaceae) (Cb) contributes significantly to primary health cares for the processing of erectile troubles. Indeed, on the fifteen (15) species of plant medicinal (distributed between 14 families) used for the various pathology processing linked to erectile troubles, Cb is the most frequently prescribed in the aforementioned canton. A phytochemical screening realized on five (5) extracted crude of roots of Cb has revealed that they contain the sterols, polyterpenes, flavonoids, saponines, tannins, reducing sugars, coumarins and proteins. Keywords: pharmacopée traditionnelle, Côte d\'Ivoire, Adzopé, screening phytochimique, érection, Caesalpinia benthamiana(Caesalpiniaceae)/traditional pharmacopoeia, Côte d'Ivoire, Adzope, erection, Caesalpinia benthamiana (Caesalpiniaceae)Sciences & Nature Vol. 4 (2) 2007: pp. 217-22

Effet antihypertensif d\'un extrait aqueux d\'écorce de tronc de Parkia biglobosa (mimosaceae) sur la pression artérielle de lapin.

Un extrait aqueux des écorces de tronc de Parkia biglobosa (EAPB), à des concentrations comprises entre 1,18 et 18, 93 mg/kg de poids corporel, induit une hypotension dose dépendante sur la pression artérielle de lapin. L'interaction Adrénaline - EAPB a révélé une réduction significative (