Sagitol C, a new cytotoxic pyridoacridine alkaloid from the sponge Oceanapia sp.

AbstractA new pyridoacridine alkaloid named sagitol C (2) together with two known compounds; kuanoniamine C (1) and sagitol (3) were isolated from the EtOAc fraction of the Indonesian sponge Oceanapia sp. Their chemical structures were established on the basis of physical and spectroscopic methods 1D and 2D NMR, in addition to mass spectrometry and comparison with literature data. Sagitol C was found to exhibit cytotoxic activity when tested against different cancer cell lines

Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp.

New mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senecio flavus (Asteraceae). Structures were established by 1D and 2D NMR, in addition to UV, IR and MS spectrometry. Compounds (3, 4 and 6) were isolated for the first time from the genus Penicillium. Compounds 1–4 showed antifungal activity against F. oxysporum and variable activities against A. flavus and the yeast C. albicans. Compounds 1–3 showed cytotoxic activity against MCF-7 cell line

New bromopyrrole alkaloids from the marine sponges axinella damicornis and stylissa flabelliformis

Investigation of the tropical sponges Axinella damicornis and Stylissa flabelliformis, family Axinillidae, afforded five new bromopyrrole alkaloids (1-5) and thirteen known compounds (6-18). Semi synthesis of S was carried out in order to confirm its structure. The structures of the isolated compounds were elucidated using ID- And 2D-NMR spectroscopy and mass spectrometry. The cytotoxicity, antimicrobial and protein-kinase inhibition activities were tested for the isolated compounds

Indole alkaloid from the Red Sea sponge Hyrtios erectus

Indole-3-carbaldehyde and 5-deoxyhyrtiosine A are reporterd for the first time in the genus Hertios, in addition to other indole alkaloids and three scalarane sesterterpenes, from the Red Sea sponge Hertios erectus. The isolated compounds were tested for their cytotoxic and antimicrobial activities

Natural anti-obesity agents

Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabetes, hypertension, and cardiovascular diseases in addition to chronic diseases such as stroke, osteoarthritis, sleep apnea, some cancers, and inflammation-based pathologies. Recent researches demonstrated the potential of natural products to counteract obesity. Multiple-natural product combinations may result in a synergistic activity that increases their bioavailability and action on multiple molecular targets, offering advantages over chemical treatments. In this review, we discuss the anti-obesity potential of natural products and analyze their mechanisms

Chemical constituents and biological investigations of the aerial parts of Egyptian Clerodendrum inerme

B-friedoolean-5-ene-3-β-ol (1), β-sitosterol (2), stigmasta-5,22,25-trien-3-β-ol (3), betulinic acid (4), and 5-hydroxy-6,7,4′-trimethoxyflavone (5) were isolated from the aerial parts of Clerodendrum inerme L. (Verbenaceae). Their structures were established based on analyses of physical and spectroscopic data. Compounds 1, 4, and 5 were isolated for the first time from the plant. C. inerme L. was known as a rich source of terpenes, sterols, and phenolic compounds, so the antioxidant and anti-inflammatory activities were evaluated. The total methanolic extract (TME) and compound 5 showed scavenging activity with maximum inhibition of 61.84% for TME (100 μg/mL) and 37.19% for 5 (20 μM), respectively, using DPPH assay. In addition, the TME exhibited anti-inflammatory activity more than indomethacin at dose 200 mg/kg using the formalin induced hind paw edema method

Terrenolide S, a new antileishmanial butenolide from the endophytic fungus <i>Aspergillus terreus</i>

<p>Terrenolide S, a new butenolide derivative (<b>6</b>), together with six known compounds: (22<i>E</i>,24<i>R</i>)-stigmasta-5,7,22-trien-3-<i>β</i>-ol (<b>1</b>), stigmast-4-ene-3-one (<b>2</b>), stigmasta-4,6,8(14),22-tetraen-3-one (<b>3</b>), terretonin A (<b>4</b>), terretonin (<b>5</b>) and butyrolactone VI (<b>7</b>) have been isolated from the endophytic fungus <i>Aspergillus terreus</i> isolated from the roots of <i>Carthamus lanatus</i> (Asteraceae). Their structures were established by extensive spectroscopic analyses (1D, 2D NMR and HRESIMS), as well as optical rotation measurement and comparison with literature data. Compound <b>1</b> displayed a potent activity towards methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and <i>Cryptococcus neoformans</i> with IC₅₀ values of 2.29 and 10.68 µM, respectively. Moreover, <b>1</b>, <b>2</b> and <b>6</b> exhibited antileishmanial activity towards <i>Leishmania donovani</i> with IC₅₀ values of 11.24, 15.32 and 27.27 µM, respectively and IC₉₀ values of 14.68, 40.56 and 167.03 µM, respectively.</p