The Imaging of Legg-Calve-Perthes Disease

Diagnosis of hip joint pathology remains a serious problem in childhood and adolescence. A wide range of pathologies—including dysplastic, dystrophic, inflammatory, oncological and post-traumatic diseases of the musculoskeletal system—leads to the advancement of imaging methods and techniques. Legg-Calve-Perthes disease (LCPD) is a common cause of hip pain in children that may be initially clinically and radiographically difficult to diagnose Radiography of the pelvis in two views (anteroposterior and Lauenstein) is the main method of diagnosing aseptic necrosis. Destructive changes of the femoral head and neck of the femur are clearly determined. However, the presence of X-ray negative patterns at the first stage of the disease and the impossibility of visualizing all the anatomical structures induce us to improve the diagnostic algorithm of this difficult pathological process

Breast and cervical cancer screening practices in nine countries of Eastern Europe and Central Asia : A population-based survey

Background: Eastern Europe and Central Asia (EECA) countries have higher cervical and breast cancer mortality rates and later stage at diagnosis compared with the rest of WHO European Region. The aim was to explore current early detection practices including “dispensarization” for breast and cervix cancer in the region. Methods: A questionnaire survey on early detection practices for breast and cervix cancer was sent to collaborators in 11 countries, differentiating services in the primary health setting, and population-based programs. Responses were received from Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, the Russian Federation (Arkhangelsk, Samara and Tomsk regions), Tajikistan, Ukraine, and Uzbekistan. Results: All countries but Georgia, Kyrgyzstan, and the Russian Federation had opportunistic screening by clinical breast exam within “dispensarization” program. Mammography screening programs, commonly starting from age 40, were introduced or piloted in eight of nine countries, organized at national oncology or screening centres in Armenia, Belarus and Georgia, and within primary care in others. Six countries had “dispensarization” program for cervix cancer, mostly starting from the age 18, with smears stained either by Romanowsky-Giemsa alone (Belarus, Tajikistan and Ukraine), or alternating with Papanicolaou (Kazakhstan and the Russian Federation). In parallel, screening programs using Papanicolaou or HPV test were introduced in seven countries and organized within primary care. Conclusion: Our study documents that parallel screening systems for both breast and cervix cancers, as well as departures from evidence-based practices are widespread across the EECA. Within the framework of the WHO Initiatives, existing opportunistic screening should be replaced by population-based programs that include quality assurance and control.Peer reviewe

Diabetes mellitus type 2 in adults

Public organization “Russian Association of Endocrinologists”. Clinical guidelines.&nbsp

Diabetes mellitus type 1 in adults

Public organization “Russian Association of Endocrinologists”. Clinical guidlines

Evaluating the effectiveness of integrated marketing communications while implementing a CRM system in the agricultural industry

This article deals with the problem of insufficient objective characteristics for determining the productivity of integrated marketing communications in business and organizations of various fields of activity, including those involved in ecology, energy, etc. The relevance of the work is due to the massive distribution of various marketing communications tools, often customized and used today through CRM systems. The aim of the study is to determine the criteria for evaluating the effectiveness of integrated marketing communications tools, reflected in CRM systems. The author uses methods of the structural and functional approach. The research is based on the descriptive and analytical method. The result of the work is a list of parameters reflected in the CRM system. They can help consider the degree of effectiveness of integrated marketing communications used in business and organizations of various fields of activity, including those involved in the field of ecology, energy, etc. Moreover, the list of criteria can be used to determine the degree of successful implementation of a CRM system and individual tools of integrated marketing communications

Foot disorders in diabetes mellitus

Diabetes mellitus is one of the most common chronic diseases in the world. According to the International Diabetes Federation (IDF), by 2035 the number of diabetes patients will reach 592 million people. Various disorders of the structure and function of the soft tissues and skeleton of the lower extremities is the most common reason that patients seek medical care. The paper presents the modern concept of the pathogenesis, diagnosis, therapeutic and prevention tactics used in the specialized endocrinological and surgical clinics

Peculiarities of assessment of content of oil products in soils

The permissible content of oil and petroleum products in the soil must have a reasonable regional standard. It should be based on presence of specific and non-specific organic compounds in each specific soil, as well as the natural conditions that cause the ability of the soil to self-cleaning, and its provincial characteristics. The value of concentrations of petroleum products in the soil at a biologically safe level has not been established now. It is impossible to justify the maximum permissible concentration of petroleum products in the soil, since they include compounds that are a necessary component of any soil. We calculated the accumulation coefficient for 106 oil fields in 15 geographical regions of the Russian Federation. The accumulation coefficient varies in a narrow range of 1.19-1.21. It is necessary to compare the results of analysis of contaminated soil with the soil before pollution or with the background to establish the fact of a decrease in soil fertility in pollution. We believe it mandatory to consider the background concentration of petroleum products, which is understood as non-specific organic compounds of soils. The question of rationing of petroleum products in the soil remains open to the present time

Biogeosystem Technique (BGT*) Methodology Will Provide Semiarid Landscape Sustainability (A Case of the South Russia Volgograd Region Soil Resources)

The science and political initiatives focus is not only concerning agricultural intensification for food security and human development. The prevention of land degradation and loss is important, and a new land-use technological platform is needed for human well-being and the ecosystem service coupling. An adverse change in the soil quality of the steppe terrain under the standard agriculture is revealed, and the dynamics of the ecosystem service is assessed. The results indicated that the standard land-use practice deteriorates stability of the soil cover, failing to ensure the soil productivity and the ecosystem services in a dry terrain. For land degradation prevention and soil-environmental services refinement, a new transcendental Biogeosystem Technique (BGT*) technological platform was developed. The BGT* is capable of providing long-term, sustainable land-use management. The BGT* methodology includes intra-soil milling, intra-soil pulse continually discrete watering, and intra-soil waste recycling. The BGT* is a basis for future political initiatives in land-use management to prevent land degradation and loss, to increase soil productivity, and to provide soil-environmental services

Upconversion Nanoparticles Intercalated in Large Polymer Micelles for Tumor Imaging and Chemo/Photothermal Therapy

Frontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue are a powerful tool for the simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles of poly(maleic anhydride-alt-1-octadecene) provided the creation of biocompatible UCNPs. The intrinsic properties of UCNPs (core@shell structure NaYF4:Yb3+/Tm3+@NaYF4) embedded in micelles delivered NIR-to-NIR visualization, photothermal therapy, and high drug capacity. Further surface modification of micelles with a thermosensitive polymer (poly-N-vinylcaprolactam) exhibiting a conformation transition provided gradual drug (doxorubicin) release. In addition, the decoration of UCNP micelles with Ag nanoparticles (Ag NPs) synthesized in situ by silver ion reduction enhanced the cytotoxicity of micelles at cell growth temperature. Cell viability assessment on Sk-Br-3, MDA-MB-231, and WI-26 cell lines confirmed this effect. The efficiency of the prepared UCNP complex was evaluated in vivo by Sk-Br-3 xenograft regression in mice for 25 days after peritumoral injection and photoactivation of the lesions with NIR light. The designed polymer micelles hold promise as a photoactivated theranostic agent with quattro-functionalities (NIR absorption, photothermal effect, Ag NP cytotoxicity, and Dox loading) that provides imaging along with chemo- and photothermal therapy enhanced with Ag NPs