Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Objective: This study presents the effects of aerobic exercise training on fasting plasma glucose and lipid profiles (FPG/LP) of diabetic patients in Kumasi.Design: A randomised experimental with control design.Setting: The study was conducted at the diabetic unit of KATH in Kumasi, Ghana.Participants: Twelve diabetic patients [grouped into intervention (IG) and control (CG)] attending the diabetic unit of KATH with diabetes diagnosis durations less than fifty years, ambulant status/age of 20-68years, sedentary and free from complications.Interventions: Eight weeks aerobic exercise training between August 2015 and March 2016 Main outcome measures: Body weight (BW), Body mass index (BMI), fasting plasma glucose (FPG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (T) and total cholesterol(TC).Results: Body weight (4.85kg, 7.0%), body mass index (4.08kg/m2, 7.3%), FPG (5.28mmol/L, 43.5%), LDL-C (.33mmol/l, 11.9%), TC (.47 mmol/l, 5.3%) and T (.48mmol/l, 29.4%) profiles of the patients in IG declined while HDL-C (.11mmol/l, 7.1%) increased. IG patients improved significantly in FPG [6.27 ± 0.91 < 8.00 ± 0.96; t=- 52.00, P = 0.000], BW [58.60 ± 15.34 < 75.35 ± 22.00; t= 3.29, P = 0.040] and BMI [23.45 ±5.03<27.04 ±4.78, t=4.24, P = .050] compared to CG.Conclusion: Patients in IG, in addition to conventional care, experienced non-significant decline in LDL-C, TC, T, increase in HDL-C and significant reduction in FPG, BW, and BMI over those receiving conventional care only. Exercise Scientists are recommended to handle exercise sessions for healthcare prevention and management routines of diabetic patients.Funding: Not declaredKeywords: Diabetic patients, Aerobic exercise training, Fasting plasma glucose, Lipoprotein, Triglycerides, Total cholestero

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.

Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10-9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

Abstract: Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10−9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations

The exploration of near-extinct indigenous Ghanaian cultural symbols for interior decoration

AbstractThe culture and artistic heritage of Ghana have been endorsed by the rich influence of Akan symbols like Adinkra, the akuaba doll, and others from various ethnic groups. However, the integration of ethnically unique near-extinct symbols into an art piece to highlight the cultural diversity of Ghana for wall hanging is rare. This work brings to life indigenous Ghanaian symbols on the verge of extinction from four ethnic groups, namely, the Akan, Ewe, Ga-Adangbe, and Mole-Dagbani to design a wall hanging for interior decoration, especially for public spaces by adopting Cora Marshal’s aesthetico research to generate a “Quali-Aesthetico” model. The design aesthetically ingrained conceptual aboriginal art and near-extinct indigenous Ghanaian symbols from the four ethnic groups as inspiration. The creative integration of these symbols yielded an interesting art piece that provides a unique ambiance for a simulated interior-decorated airport and an art gallery suitably displayed on flat interior surfaces. Besides the artistic expression of the art piece, interpretations of the uniquely combined symbols and their philosophical meanings have been provided to educate the public about the rich Ghanaian cultural heritage. The art piece also seeks to preserve near-extinct identity symbols and create a sense of belonging for the younger generation

Functional paradox of leptin and adiponectin in diabetes patients and controls in the Cape Coast Metropolis of Ghana

Aim: To investigate the concept of obesity paradox in diabetes patients and nondiabetic control in the Cape Coast Metropolis of Ghana. Materials and Methods: Levels of leptin, adiponectin, total antioxidant power (TAP), lipid peroxides, and C-reactive protein (CRP) were assessed in 115 diabetics and an equal number of control respondents. Furthermore, various anthropometric indices and blood pressure were measured using standard methods. Levels of biomarkers were compared between groups based on body mass index or blood pressure classifications. Results: Control respondents exhibited higher (P 0.05) mean levels of the various biomarkers, except TAP level which was higher (P 0.05) levels of the other biomarkers between diabetes patients and their control counterpart. Irrespective of diabetes, obesity, or hypertensive status, leptin associated positively with various measures of adiposity. Adiponectin correlated positively with leptin (R > 0.38; P< 0.05) only in the control respondents, suggesting a possible functional paradox of the adipocytokines in this group of respondents. Conclusion: Overweight/obese respondents appear metabolically healthier than their normal-weight counterparts. However, further studies are needed for proper understanding of this concept in the Ghanaian context

Consumer attitude and disposal behaviour to second-hand clothing in Ghana

The issue of second-hand clothing which is exported from Europe and America into the African market remains a critical problem that poses threats to the eco-system. These clothing are sometimes unusable and have a limited life span which is eventually disposed of into landfills and water bodies. Thus, producing smells and toxic chemicals that pollute the air and environment when burnt or left to decompose. These indiscriminate disposals have been a major concern to citizens, stakeholders, and Governments. With the recurring threats posed by this practice, new technological innovations have been proposed and developed by leading brands and new start-ups in the industry to limit such negative impacts. Several studies on second-hand clothing are from the Global South, with limited research conducted by researchers within developing countries to understand the influence of behaviours and attitudes of consumers on the purchase of this clothing. Hence, this paper presents the first attempt to understand consumer attitudes towards the purchase and disposal of second-hand clothing in the environment of Ghana. Furthermore, the initial sections of the paper highlight new technologies and approaches developed by global brands and start-ups in Africa to curb second-hand clothing waste. A structured online questionnaire was developed and used to collect empirical data from 135 consumers in the Ashanti and Greater Accra regions of Ghana, a context that few studies have focused on. The regression analysis revealed that both attitude and disposal behaviour have a significantly positive influence on the consumption intention of consumers. Lastly, attitude had a positive and no significant impact on the relationship between disposal behaviour and consumption intention. Findings contribute to appropriate policy and regulation formation, the need for education, and environmental perspectives on the effects of these clothing for the implementation of circular initiatives. Hence, the study recommends the provision of waste bins, the establishment of recycling plants, and the enforcement of strict regulations to limit the importation of second-hand clothing into the Ghanaian markets

Elevated adiponectin but varied response in circulating leptin levels to falciparum malaria in type 2 diabetics and non-diabetic controls

Background: To investigate effects of falciparum malaria on circulating levels of leptin and adiponectin in type 2 diabetes mellitus (T2DM) and non-diabetic controls in relation to measures of adiposity. Methods: Levels of leptin and adiponectin were measured in 100 type 2 diabetics and 100 age-matched controls before and during falciparum malaria in a 2-year prospective study. Also, waist circumference (WC), weight, height and hip circumference were measured. Body mass index (BMI) and waist-to-hip ratio (WHR) were computed. Results: At baseline, diabetics had significantly (p  0.05) between diabetics and controls. However, compared to baseline levels, significant (p < 0.001) elevation of adiponectin was found in both study groups. In respect of leptin, significant (p < 0.001) rise but decline was observed in diabetics and controls respectively. Malaria-induced leptin correlated negatively with adiponectin (r = â0.694; p < 0.001) in non-diabetic controls only. Conclusion: Diabetics and controls exhibited increased adiponectin levels due to falciparum malaria but differed in response in terms of leptin levels. Keywords: Falciparum malaria, T2DM, Leptin, Adiponectin, BM

Evaluation of Metabolic Syndrome and Its Associated Risk Factors in Type 2 Diabetes: A Descriptive Cross-Sectional Study at the Komfo Anokye Teaching Hospital, Kumasi, Ghana

Background. Metabolic syndrome (MS) is a collection of cardiovascular risk factors comprising insulin resistance, dyslipidemia, obesity, and hypertension, which may cause further complications in diabetes. Although metabolic syndrome (MS) is increasing in incidence in diabetics and leading to significant cardiovascular diseases and mortality, there is dearth of data in Ghana. This study investigated metabolic syndrome, its prevalence, and its associated risk factors in type 2 diabetes at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Methods. The study involved 405 diabetic patients attending the Diabetic Clinic of the Komfo Anokye Teaching Hospital (KATH) Kumasi, in the Ashanti Region of Ghana. A well-structured questionnaire was used to obtain demographic background such as their age and gender. Anthropometric measurements were obtained using the Body Composition Monitor (Omron ® 500, Germany) which generated digital results on a screen and also by manual methods. Fasting venous blood was collected for the measurement of biochemical parameters comprising fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-c), and triglyceride (TG). Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). Results. Out of the total of 405 participants, 81 were males and 324 were females, and the estimated mean age was 58.5 ± 9.9 years. The female patients exhibited higher mean waist circumference (WC) and mean hip circumference (HC) as well as an approximately higher body mass index than males (28.3 ± 5.1, 26.5 ± 4.2 for the female and male respectively). Overall, the prevalence of metabolic syndrome observed among the study population was 90.6%. Conclusions. The prevalence of metabolic syndrome observed among the study population was 90.6%, with a higher percentage in females than males. High triglyceride levels and high waist circumference were the main risk factors for MS in the diabetic population