Sound absorption and reflection with coupled tubes

This paper describes a special sound absorbing technique with an accompanying efficient numerical design tool. As a basis pressure waves in a single narrow tube or pore are considered. In such a tube the viscosity and the thermal conductivity of the air, or any other fluid, can have a significant effect on the wave propagation. An important aspect is that due to the viscothermal wave propagation sound energy is being dissipated. This has been applied to configurations consisting of a manifold of tubes, the so-called coupled tubes. A design strategy was developed to create broadband sound absorption for a wall with configurations of coupled tubes. The viscothermal wave propagation in tubes is accounted for in B2000 via one-dimensional T2.VISC and T3.VISC elements. Also further applications of coupled tubes are described: a network of small coupled tubes is used as a numerical representation of conventional sound absorbing material and increased damping of flexible plates connected to a small air layer is created with tubes coupled to this air layer

Noise reduction with coupled prismatic tubes

The present investigation focuses on an accurate description of sound absorption. Within this research a new technique to create sound absorption for a predefined frequency band has been developed. Additionally, a simple and efficient numerical model for conventional sound absorbing materials, such as glass wool or foams, has been formulated. It is also demonstrated that the newly gained insights are useful in applications not directly related to sound absorption

Potential of mean force by thermodynamic integration: molecular-dynamics simulation of decomplexation

“Umbrella sampling” has been incorporated in the thermodynamic integration method to obtain a potential of mean force by slow growth molecular-dynamics simulations. The method was tested for liquid argon, for which good agreement was obtained with a standard potential of mean force, as derived from the radial pair-correlation function. For a sodium chloride ion-pair in aqueous solution the calculations showed resonable agreement with a literature result. The method was also applied to the decomplexation of 18-crown-6 and a potassium cation in aqueous solution

Modelling of the diffusion of carbon dioxide in polyimide matrices by computer simulation

Computer aided molecular modelling is used to visualize the motion of CO2 gas molecules inside a polyimide polymer matrix. The polymers simulated are two 6FDA-bases polyimides, 6FDA-4PDA and 6FDA-44ODA. These polymers have also been synthesized in our laboratory, and thus the simulated properties could directly be compared with “real-world” data. The simulation experiments have been performed using the GROMOS1 package. The polymer boxes were created using the soft-core method, with short (11 segments) chains. This results in highly relaxed and totally amorphous polyimide matrices. The motion of randomly placed CO2 molecules in the boxes during molecular dynamics runs was followed, revealing three types of motion: jumping, continuous- and trapped motion. The calculated diffusivities are unrealistic, but possible shortcomings in our model are given

Size distribution of embryos produced by crystal-rod contacts

We performed contact nucleation experiments on the (010) face of potassium hydrogen phthalate (KAP) crystals growing in a stagnant supersaturated aqueous solution and determined - after a given growth time t - (ex situ) the crystal size distribution (CSD) of the secondary nuclei (which at t = 0 are called "embryos") by using a scanning electron microscope (SEM). The origin of the secondary nuclei could clearly be revealed (damage to the crystal surface). The CSD can be fitted with a log-normal distribution which is typical for many powders obtained by grinding. Minimum size and mean size can be quantitatively understood by elementary fracture mechanics

A novel technique for measuring the reflection coefficient of sound absorbing materials

A new method to measure the acoustic behaviour of sound absorbing material in an impedance tube is presented. The method makes use of a novel particle velocity sensor, the microflown, and a microphone. The so-called p·u method is compared to three other methods of which the two microphone technique is well known. It is shown that the combination of a microphone and a microflown provides direct information on the acoustic impedance, the sound intensity and the sound energy density. The experimental results are compared to the results obtained with the conventional impedance tube measurements. To be able to repeat the measurements in a reliable way a well described test sample with a quarter-wave resonator is used. Furthermore it is shown that the viscothermal effects on the wave propagation are important, i.e. for the quarter-wave resonator and to a lesser extent for the impedance tube itself

Maternal Illness at the Limits of Fetal Viability

Groot, C.J.M. de [Promotor]Bolte, A.C. [Copromotor]Zeeman, G.G. [Copromotor

Individualized dosing strategies for Oncolytic agents and Intoatumoral Pharmacokinetics

In the first part of my thesis, we discuss strategies to personalize the dose of anticancer drugs, for example via the implementation of Therapeutic Drug Monitoring or pharmacogenetic guided dosing. In the second part of my thesis, we focus on the intratumoral pharmacokinetics of different types of chemotherapy and possible strategies to improve the intratumoral exposure to chemotherapy