Metropolitan Transportation Commission Discretionary Transit Funding Methods Evaluation

In 2021, the Santa Clara Valley Transportation Authority (VTA) approached the Mineta Transportation Institute (MTI) with a proposal to have MTI provide an evaluation of the Metropolitan Transportation Commission’s (MTC’s) operational discretionary funding allocation policies and methods for Bay Area transit operators. The research was done in two parts. Part 1 investigated MTC’s past and current allocation methods for discretionary operational transit funding programs; Part 2 involved the evaluation of outcomes if MTC employed alternative allocation methods. After the Part 1 review of MTC’s various transit funding programs, the federal pandemic relief funds and the Transportation Development Act/State Transit Assistance (TDA/STA) funding programs were selected and evaluated in Part 2 using a set of five alternative allocation metrics and compared to actual MTC allocations. Key findings include: (1) the population-based metric produced the largest increase for VTA’s pandemic relief funds, with VTA receiving 221 percent more than MTC actually allocated in 2020 and 2021, but the San Francisco Municipal Transportation Agency (SFMTA) receiving 64 percent less; (2) the ridership-based metric yielded the smallest amount of VTA pandemic funding, but high ridership operators such as SFMTA would have a 41 percent increase; (3) the population-based metric produced the largest increase in STA funding to VTA but would come at the expense of other transit operators, with Sonoma County receiving 51 percent less; and (4) the ridership-based metric yielded the smallest amount of STA funds for VTA, with 50 percent less funding than actual, while high ridership operators such as SFMTA, would see a roughly 400 percent increase. Thoroughly investigating current and alternative funding allocation methods and policies is critical to understanding their effects on transit agencies and the communities they serve

Analysis of the Benefits of Green Streets

Green streets offer many potential benefits that include improving water quality, absorbing carbon (sequestration), and reducing urban heat island effects. This report summarizes: (1) the research team’s analysis of 14 tools calculating green streets benefits; and (2) the results of applying the most promising calculators to a select group of green streets case studies. The researchers are affiliated with the Mineta Transportation Institute, which serves the California Department of Transportation (“Caltrans”). The report presents the results of the case study analyses, with an emphasis on carbon sequestration benefits and improvements to pedestrian levels of service (PLOS). Trees absorb carbon dioxide and other pollutants from the air, reducing the costs of future climate change mitigations and medical care. Key findings obtained using i-Tree Design suggest that the monetary value (CO2 and air quality) of planting street trees is small but significant, with total estimated benefits from street trees on seven case study sites ranging from a low of $1,466 to a high of$9,420 over a 20-year period. On a per tree basis, the lowest benefits come from site 3A (Cherry Avenue in San Jose) with $10 per tree, and the highest come from site 1A (San Pablo Avenue in El Cerrito) at$175 per tree. While the Landis PLOS method accounts for the benefits of short street tree spacings (i.e., a high number of trees) and of having a continuous biostrip or planter strip serving as a pedestrian buffer, the method does not appear to be sensitive to tree spacings, though it is very sensitive to buffers. Therefore, the importance of having a biostrip or planter strip buffer between the sidewalk and street traffic is also reflected in the PLOS findings in this study. While the measurable benefits of a handful of street trees may seem small, this study suggests that using i-Tree Design to add together the trees planted by local and state agencies has the potential to provide a compelling picture of the carbon sequestration benefits across California. Similarly, the use of Highway Capacity Manual (HCM)-based pedestrian level of service methods by transportation professionals can bring significant gains in the appreciation of green streets’ benefits

Characteristics of Effective Metropolitan Areawide Public Transit: A Comparison of European, Canadian, and Australian Case Studies

This research project investigates the replicable characteristics, policies, and practices of successful metropolitan areawide public transportation networks that contribute to high usage and make transit an effective competitor to the private motor vehicle. The research method involves the qualitative and quantitative analysis of ten international (non-U.S.) case studies. The principal methods employed were web-based research and data collection, as well as telephone interviews with transit agency staff or regional planners as needed. The case studies were limited to developed western countries with similar metropolitan conditions to those in the United States. This research focuses on key characteristics of highly effective regional transit systems from the perspective of the metropolitan area, not the individual transit operators. These characteristics fall within three broad categories: the setting of the metropolitan area; the customer-apparent transit service features; and the behind-the-scenes or institutional characteristics. Key findings are: (1) all ten case studies have a metropolitan areawide regional transit coordinator (RTC); (2) RTCs yield benefits in terms of ridership and operating efficiencies that are discernable from the effects of high transit funding and subsidies; (3) all case studies had some degree of fare integration, and most had complete regionwide fare integration; and (4) transit service was frequent, abundant, and affordable in all cases. The features of excellent regionwide transit systems that have been identified in this research can be applied to U.S. metropolitan areas with multiple players, yielding effective, efficient, and high mode share public transit at the regional level. The research can help U.S. policy makers and planners begin to improve the appropriate aspects of their own regional transit systems, including by improving coordination and organizational structures

Acquired Resilience: An Evolved System of Tissue Protection in Mammals.

This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level, cause tissue destruction. This pattern of response to stress is well known to toxicologists, who have termed it hormesis. The phenotypes of resilience are diverse and reports of stress-induced resilience are to be found in journals of neuroscience, sports medicine, cancer, healthy ageing, dementia, parkinsonism, ophthalmology and more. This diversity makes the proposing of a general concept of induced resilience a significant task, which this review attempts. We suggest that a system of stress-induced tissue resilience has evolved to enhance the survival of animals. By analogy with acquired immunity, we term this system \u27acquired resilience\u27. Evidence is reviewed that acquired resilience, like acquired immunity, fades with age. This fading is, we suggest, a major component of ageing. Understanding of acquired resilience may, we argue, open pathways for the maintenance of good health in the later decades of human life

New constructions of twistor lifts for harmonic maps

We show that given a harmonic map $\varphi$ from a Riemann surface to a classical compact simply connected inner symmetric space, there is a $J_2$-holomorphic twistor lift of $\varphi$ (or its negative) if and only if it is nilconformal. In the case of harmonic maps of finite uniton number, we give algebraic formulae in terms of holomorphic data which describes their extended solutions. In particular, this gives explicit formulae for the twistor lifts of all harmonic maps of finite uniton number from a surface to the above symmetric spaces.Comment: Some minor changes and a correction of Example 8.

Defining and Measuring Equity in Public Transportation

65A0660Transit should serve all users, regardless of age, race, ability, or any other identity. Policies and planning must be conscious of inequities when defining and measuring equity in public transportation. This study was done to aid the California Department of Transportation (Caltrans) and the state\u2019s transit agencies in assessing transit service equity and assisting with evaluating past, existing, and future inequities. This report identifies and evaluates policies and practices associated with equity measurement in public transit from extant academic and professional literature sources. These include the Federal laws and regulations addressing Title VI of the 1964 Civil Rights Act and the measurement tools (i.e., metrics) that are used to identify and evaluate equity impacts related to transit benefits and costs. The report identifies a list of candidate metrics and applies them to a test case in Santa Cruz County, California, and compares their results to those generated by the metrics required by Title VI (race and income) for transit equity analysis. From this comparison, the study evaluated the need for new metrics in transit equity. Findings suggest that these traditional Title VI measures do not correlate well with other potential measures of inequity. Hence, transit inequity is a multifaceted problem with several potential different measures, each revealing an aspect of inequity. Caltrans and other transit-related agencies need to reach beyond these traditional measures, finding metrics that address the specific, context appropriate equity conditions of the communities they are measuring to ensure fair and equal public transportation for all

Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

ABSTRACT: Diabetes causes oxidative stress in the liver and other tissues prone to complications. Photobiomodulation by near infrared light (670 nm) has been shown to accelerate diabetic wound healing, improve recovery from oxidative injury in the kidney, and attenuate degeneration in retina and optic nerve. The present study tested the hypothesis that 670 nm photobiomodulation, a low-level light therapy, would attenuate oxidative stress and enhance the antioxidant protection system in the liver of a model of type I diabetes. Male Wistar rats were made diabetic with streptozotocin (50 mg/kg, ip) then exposed to 670 nm light (9 J/cm 2 ) once per day for 18 days (acute) or 14 weeks (chronic). Livers were harvested, flash frozen, and then assayed for markers of oxidative stress. Light treatment was ineffective as an antioxidant therapy in chronic diabetes, but light treatment for 18 days in acutely diabetic rats resulted in the normalization of hepatic glutathione reductase and superoxide dismutase activities and a significant increase in glutathione peroxidase and glutathione-S transferase activities. The results of this study suggest that 670 nm photobiomodulation may reduce, at least in part, acute hepatic oxidative stress by enhancing the antioxidant defense system in the diabetic rat model.

Evaluating Molecular Mechanism of Viral Inhibition of Aerosolized Smart Nano-Enabled Antiviral Therapeutic (SNAT) on SARS-CoV-2-Infected Hamsters

Smart Nano-enabled Antiviral Therapeutic (SNAT) is a promising nanodrug that previously demonstrated efficacy in preclinical studies to alleviate SARS-CoV-2 pathology in hamsters. SNAT comprises taxoid (Tx)-decorated amino (NH2)-functionalized near-atomic size positively charged silver nanoparticles (Tx–[NH2-AgNPs]). Herein, we aimed to elucidate the molecular mechanism of the viral inhibition and safety of aerosolized SNAT treatment in SARS-CoV-2-infected golden Syrian hamsters. High-resolution transmission electron microscopy (HR-TEM) coupled with energy dispersive spectroscopy (EDS) and ELISAs showed SNAT binds directly to the SARS-CoV-2 virus by interacting with intact spike (S) protein, specifically to S2 subunit. SNAT (≥1 µg/mL) treatment significantly lowered SARS-CoV-2 infections of Calu-3 cells. Extraction-free whole transcriptome assay was used to detect changes in circulatory micronome in hamsters treated intranasally with SNAT (two doses of 10 µg/mL of 2 mL each administered 24 h apart). Uninfected hamsters treated with SNAT had altered circulatory concentrations of 18 microRNAs (8 miRNAs upregulated, 10 downregulated) on day 3 post-treatment compared to uninfected controls. SNAT-induced downregulation of miR-141-3p and miR-200b-3p may reduce viral replication and inflammation by targeting Ythdf2 and Slit2, respectively. Further, SNAT treatment significantly lowered IL-6 expression in infected hamster lungs compared to untreated infected hamsters. Taken together, we demonstrate that SNAT binds directly to SARS-CoV-2 via the S protein to prevent viral entry and propose a model by which SNAT alters the cellular miRNA-directed milieu to promote antiviral cellular processes and neutralize infection. Our results provide insights into the use of low-dose intranasally delivered SNAT in treating SARS-CoV-2 infections in a hamster model

Acquired Resilience: An Evolved System of Tissue Protection in Mammals

This review brings together observations on the stress-induced regulation of resilience mechanisms in body tissues. It is argued that the stresses that induce tissue resilience in mammals arise from everyday sources: sunlight, food, lack of food, hypoxia and physical stresses. At low levels, these stresses induce an organised protective response in probably all tissues; and, at some higher level, cause tissue destruction. This pattern of response to stress is well known to toxicologists, who have termed it hormesis. The phenotypes of resilience are diverse and reports of stress-induced resilience are to be found in journals of neuroscience, sports medicine, cancer, healthy ageing, dementia, parkinsonism, ophthalmology and more. This diversity makes the proposing of a general concept of induced resilience a significant task, which this review attempts. We suggest that a system of stress-induced tissue resilience has evolved to enhance the survival of animals. By analogy with acquired immunity, we term this system ‘acquired resilience’. Evidence is reviewed that acquired resilience, like acquired immunity, fades with age. This fading is, we suggest, a major component of ageing. Understanding of acquired resilience may, we argue, open pathways for the maintenance of good health in the later decades of human life