Plant cell walls: impact on nutrient bioaccessibility and digestibility

Cell walls are important structural components of plants, affecting both the bioaccessibility and subsequent digestibility of the nutrients that plant-based foods contain. These supramolecular structures are composed of complex heterogeneous networks primarily consisting of cellulose, and hemicellulosic and pectic polysaccharides. The composition and organization of these different polysaccharides vary depending on the type of plant tissue, imparting them with specific physicochemical properties. These properties dictate how the cell walls behave in the human gastrointestinal tract, and how amenable they are to digestion, thereby modulating nutrient release from the plant tissue. This short narrative review presents an overview of our current knowledge on cell walls and how they impact nutrient bioaccessibility and digestibility. Some of the most relevant methods currently used to characterize the food matrix and the cell walls are also described

Implementing Interprofessional Education: Challenges for CSD Graduate Programs

The focus on interprofessional education (IPE) for professional training programs in allied health professions, such as speech-language pathology, has recently increased. There is currently limited pedagogical literature regarding both the instruction and application of IPE in any given discipline. This paper will outline challenges CSD graduate programs may face when implementing IPE content within the existing curricula and explore possible solutions. Delineation of preparation and integration process of an IPE course taught at a small liberal arts university where it was cross-listed in two undergraduate pre-professional programs in speech-language pathology and social work will be provided. Elements of the course, including delivery, descriptions of assignments, and projects, will also be discussed and how this undergraduate course may facilitate implementing IPE content into the graduate curriculum

Eph Receptors and Ephrin Signaling Pathways: A Role in Bone Homeostasis

The maintenance of bone homeostasis is tightly controlled, and largely dependent upon cellular communication between osteoclasts and osteoblasts, and the coupling of bone resorption to bone formation. This tight coupling is essential for the correct function and maintenance of the skeletal system, repairing microscopic skeletal damage and replacing aged bone. A range of pathologic diseases, including osteoporosis and cancer-induced bone disease, disrupt this coupling and cause subsequent alterations in bone homeostasis. Eph receptors and their associated ligands, ephrins, play critical roles in a number of cellular processes including immune regulation, neuronal development and cancer metastasis. Eph receptors are also expressed by cells found within the bone marrow microenvironment, including osteoclasts and osteoblasts, and there is increasing evidence to implicate this family of receptors in the control of normal and pathological bone remodeling

Gr-1+CD11b+ Myeloid-Derived Suppressor Cells: Formidable Partners in Tumor Metastasis

The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis. © 2010 American Society for Bone and Mineral Research

"You are just left to get on with it": qualitative study of patient and carer experiences of the transition to secondary progressive multiple sclerosis

Objectives Although the transition to secondary progressive multiple sclerosis (SPMS) is known to be a period of uncertainty for clinicians, who may find progressive disease challenging to objectively identify, little research has explored the experiences of patients and carers specifically during this transition period. Our objective was to explore what patients and their carers understand about their disease stage and describe their experiences and perspectives on the transition to SPMS. Design Semistructured qualitative interviews and subsequent validation focus groups were analysed using inductive thematic analysis. Setting South East Wales, UK. Participants 20 patients with MS and 13 carers were interviewed. Eight patients and two carers participated in focus groups. Results Four main themes around disease progression were identified. ‘Realisation’ describes how patients came to understand they had SPMS while ‘reaction’ describes their response to this realisation. The ‘realities’ of living with SPMS, including dealing with the healthcare system during this period, were described along with ‘future challenges’ envisaged by patients and carers. Conclusions Awareness that the transition to SPMS has occurred, and subsequent emotional reactions and coping strategies, varied widely between patients and their carers. The process of diagnosing the transition was often not transparent and some individuals wanted information to help them understand what the transition to SPMS meant for them

The effect of EMAT coil geometry on the Rayleigh wave frequency behaviour

Understanding of optimal signal generation and frequency content for electromagnetic acoustic transducers (EMATs) is key to improving their design and signal to noise ratio. Linear and meander coil designs are fairly well understood, but other designs such as racetrack or focused coils have recently been proposed. Multiple transmission racetrack coil EMATs, with focused and unfocused designs, were constructed. The optimum driving frequency for maximum detected signal was found to range between 1.1 and 1.4 MHz on aluminium for a 1.5 mm width coil. A simple analytical model based on the instantaneous velocity of a wave predicts a maximum signal at 1.44 MHz. Modelling the detection coil as a spatial square wave agrees with this, and predicts a general relation of f =0.761v/L between the optimum frequency f , the wave velocity v, and the coil width L. A time domain model of the detection coil predicts a 1.4-1.5 MHz peak for continuous wave excitation, with a frequency that decreases as the length of the wavepacket is decreased, consistent with the experimental data. Linear coil modelling using the same technique is shown to be consistent with previous work, with improving detection at lower wave frequencies, and signal minima at every integer multiple of the wavelength. Finite Element Analysis (FEA) is used to model the effects of the spatial width of the racetrack generation coil and focused geometry, and no significant difference is found between the focused and the unfocused EMAT response. This highlights the importance of designing the EMAT coil for the correct lift-off and desired frequency of operation. [Abstract copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

A comparative study of selected sorbents for sampling of aromatic VOCs from indoor air

Indoor air canbecome pollutedwith VOCs, and understanding the factors which affect adsorption of VOCs from indoor air is important for: (i) the accurate measurement of VOCs, and (ii) to apply mitigation strategies when high analyte concentrations are measured. In this study four VOCs (toluene, ethylbenzene, cumene and dichlorobenzene) were generated as a constant and controlled polluted air stream of VOCs from a dynamic atmospheric chamber. The effects of relative humidity, and sampling flow rate, on adsorption onto Tenax TA and the relatively new silica adsorbents SBA-15 or MCM-41 were studied

The depression in visual impairment trial (DEPVIT): trial design and protocol

<b>Background</b> The prevalence of depression in people with a visual disability is high but screening for depression and referral for treatment is not yet an integral part of visual rehabilitation service provision. One reason for this may be that there is no good evidence about the effectiveness of treatments in this patient group. This study is the first to evaluate the effect of depression treatments on people with a visual impairment and co morbid depression.<p></p> <b>Methods/design</b> The study is an exploratory, multicentre, individually randomised waiting list controlled trial. Participants will be randomised to receive Problem Solving Therapy (PST), a ‘referral to the GP’ requesting treatment according to the NICE’s ‘stepped care’ recommendations or the waiting list arm of the trial. The primary outcome measure is change (from randomisation) in depressive symptoms as measured by the Beck’s Depression Inventory (BDI-II) at 6 months. Secondary outcomes include change in depressive symptoms at 3 months, change in visual function as measured with the near vision subscale of the VFQ-48 and 7 item NEI-VFQ at 3 and 6 months, change in generic health related quality of life (EQ5D), the costs associated with PST, estimates of incremental cost effectiveness, and recruitment rate estimation.<p></p> <b>Discussion</b> Depression is prevalent in people with disabling visual impairment. This exploratory study will establish depression screening and referral for treatment in visual rehabilitation clinics in the UK. It will be the first to explore the efficacy of PST and the effectiveness of NICE’s ‘stepped care’ approach to the treatment of depression in people with a visual impairment.<p></p&gt

Educational intervention guide. Promoting positive masculinities for the prevention of violence against women. Conceptual toolbox and activities

Violence against women (VAW) is one of the world’s most persistent and destructive societal problems. It does not occur in isolation as it is strongly influenced by the ways gender relations are constructed and by the ways femininities and masculinities are culturally represented and negotiated in daily interactions. Many of the beliefs, behaviours and attitudes that sustain VAW are related to gendered expectations and norms. That is why it is so important to work on our understanding of gender relations and roles in VAW prevention. This educational intervention guide was created in the context of the PositivMasc Project, which was carried out from 2019-2022 by researchers in Ireland, Israel, Spain and Sweden and funded by the GENDER-NET European research network. The PositivMasc project aims to explore discourses of non-violent forms of masculinity and ways in which to support and promote positive masculinities for the prevention of VAW among young people and in society (Salazar et al., 2020). In fact, more positive expressions of masculinities (non-violent, inclusive, empathetic, caring, or egalitarian) are emerging in society, advocated by women and men fighting against different forms of VAW (Elliott, 2016). One of the key concepts underpinning this document is positive masculinities, which refers to potential alternatives to hegemonic masculinity and ways of promoting more inclusive, empathetic, caring and equitable forms of manhood and gender equity (Foley et al., 2015; Pérez-Martínez et. al, 2021). As part of the PositivMasc project goals related to research dissemination and research impact, we present this guide which includes a conceptual toolbox and activities for engaging young people in actively rethinking gender relations and promoting gender-equitable and healthy relationships free of VAW.This work was supported by GENDER NET Plus Co-Fund (reference number 2018-00968). We also want to acknowledge the financial support received from the Swedish Research Council (Grant number: 2018-00968); the Irish Research Council; The Ministry of Science & Technology of Israel (3-15662) and the Ministry of Science and Innovation of Spain (Ref. PCI2019-103580)

Myeloma cells down‐regulate adiponectin in bone marrow adipocytes via TNF‐alpha

Multiple myeloma is caused by abnormal plasma cells that accumulate in the bone marrow and interact with resident cells of the bone microenvironment to drive disease progression and development of an osteolytic bone disease. Bone marrow adipocytes (BMAds) are emerging as having important endocrine functions that can support myeloma cell growth and survival. However, how BMAds respond to infiltrating tumor cells remains poorly understood. Using the C57BL/KaLwRij murine model of myeloma, bone marrow adiposity was found to be increased in early stage myeloma with BMAds localizing along the tumor‐bone interface at later stages of disease. Myeloma cells were found to uptake BMAd‐derived lipids in vitro and in vivo, although lipid uptake was not associated with the ability of BMAds to promote myeloma cell growth and survival. However, BMAd‐derived factors were found to increase myeloma cell migration, viability, and the evasion of apoptosis. BMAds are a major source of adiponectin, which is known to be myeloma‐suppressive. Myeloma cells were found to downregulate adiponectin specifically in a model of BMAds but not in white adipocytes. The ability of myeloma cells to downregulate adiponectin was dependent at least in part on TNF‐α. Collectively our data support the link between increased bone marrow adiposity and myeloma progression. By demonstrating how TNF‐α downregulates BMAd‐derived adiponectin, we reveal a new mechanism by which myeloma cells alter the bone microenvironment to support disease progression. © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research