Maximum and Minimum value of parameters.

<p>Maximum and Minimum value of parameters.</p

Fit of UCLA rabbit model to experimentally recorded AP data set 2.

<p>(A): The base UCLA rabbit ionic model (red) was fit to experimental data set 2 (green) using just the AP (blue), and the AP+R_m (magenta) measured at 4 different points (black stars). Orange square markers represent the corresponding voltage points in AP+R_m fit curve obtained from genetic algorithm. (B): Plot of normalized average and SD of parameters from the Pareto set generated from the genetic algorithm output from AP only and AP+R_m fits. Bars show normalized averages with SD for the optimal values of particular parameters with AP (grey) and AP+R_m fits (black).</p

Changes in reentry dynamics as a function of PMJ density.

<p>A) Portion of successful junctional propagations as a function of PMJ density B) Average MFR in ventricles and Purkinje system as a function of PMJ density C) WBI on epicardium and endocardium as a function of PMJ density ( = 20 M,  = 20).</p

Activation maps for different PMJ densities.

<p>Excitation of the ventricular myocardium by the Purkinje system during sinus rhythm for Purkinje system models with three different numbers of PMJ as indicated on the left. Activation time since His bundle stimulation is scaled between earliest and last epicardial activation over all simulations.</p

Measurement of R_m using voltage clamp pulses to determine the voltage-current (V-I) relationship.

<p>(A): Timing of onset of clamp pulses during different phases of the TNNP ventricle model AP are indicated by the stars. (B): Application of voltage clamp pulses 10 mV above (red curve) and below (blue curve) the membrane voltage at fifth point in the previous panel. (C): Membrane currents (Im) corresponding to clamp pulses in panel B. (D): V_m -I_m graph for the calculation of membrane resistance.</p

Two parameter sets for the TNNP ventricle model showing similar AP [3].

<p>Control value in the second column shows the value as published. Parameter sets #1 and #2 show percentage change from the control value.</p><p>Two parameter sets for the TNNP ventricle model showing similar AP <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107984#pone.0107984-Hodgkin1" target="_blank">[3]</a>.</p

Instances of conduction success and failure at one PMJ.

<p>A) successful retrograde propagation, B) failed retrograde propagation C) failed anterograde propagation D) successful anterograde propagation.</p

Purkinje system contribution during reentry.

<p>A) Rotors on the epicardium surface along with phase singularities indicated by red asterisks. B) Filaments in ventricles colocalized with Purkinje system endpoints. I-shaped filaments which terminate close to Purkinje system endpoints are shown in green, and O-shaped filaments which formed close to Purkinje system endpoints are indicated in orange. Surface phase singularities are as in A.</p

Effects of PMJ size on reentr.

<p>A) Sensitivity of average MFR in Purkinje system to the size of PMJ B) Sensitivity of WBI on epicardium to size of PMJ ( = 20 M).</p

Effect of changing tissue coupling with the two parameters sets of TNNP model.

<p>Red and blue curve show the APs for parameter set 1 and 2 for TNNP model. The green curve shows the AP for parameter set 2 when the coupling has been decreased by a factor of 10. The purple dotted curve shows the curve for parameter set1 with the coupling increased by a factor of 10.</p