Levels of antibody IgG sub-classes against hepatitis B in vaccinated infants.

<p>Plasma levels of HbsAg-specific IgG sub-classes in 6 to 7 months old infants born to mothers infected (M+) or not (M−) with <i>T. cruzi</i>, and congenitally infected (B+) or not (B−), and vaccinated at 2, 4 and 6 months against hepatitis B. Results are displayed as box and whiskers (n = 6 M−B−, 13 M+B− and 9 M+B+). * : p<0.05 compared with infants from other groups (Man Withney <i>U</i> test).</p

IFN-γ and IL-13 productions in response to SEB by blood mononuclear cells from newborns and infants.

<p>Newborns and 6 to 7 months-old infants were born either to <i>T. cruzi-</i>infected (M+) or not infected mothers (M−), and either congenitally infected (B+) or not (B−). Cells were cultured during 6 days in the presence of 10 ng/mL SEB (staphylococcal enterotoxin B). Results of cytokines levels measured by ELISA (individual results and geometric means) are shown. * : p<0.05 and ** : p<0.005 (Mann-Withney <i>U</i> test).</p

Cytokine response to PPD in infants vaccinated with BCG.

<p>IFN-γ and IL-13 production in response to tuberculin purified protein derivative of <i>M. tuberculosis</i> (PPD) by PBMC from 6 to 7 months old infants born to mothers infected (M+) or not (M−) with <i>T. cruzi</i>, and congenitally infected (B+) or not (B−), and having received at birth the BCG vaccine. PBMC were cultured during 6 days in the presence of 10 µg/mL PPD. Results of cytokines levels measured by ELISA are shown (individual results and geometric means). The proportions of responders (i.e. showing detectable levels of cytokines) are also shown. * : p<0.05 and ** : p = 0.006 compared with M−B− infants (Mann-Withney <i>U</i> test for means and Fisher test for proportions).</p

Production of IFN-γ and IL-13 in response to vaccinal antigens by PBMC from infants from mothers infected (M+) or not (M−),with <i>T. cruzi</i>, and congenitally infected (B+) or not (B−).

a<p>Arithmetic mean±SEM.</p

Antibody levels against hepatitis B, diphtheria and tetanus vaccines in newborns and infants.

<p>Plasma levels of specific IgG in newborns and 6 to 7 months old infants born to mothers infected (M+) or not (M−) with <i>T. cruzi</i>, and congenitally infected (B+) or not (B−), and vaccinated at 2, 4 and 6 months against hepatitis B, diphtheria and tetanus. Results are shown as geometric means; extreme values are indicated, as well as the proportion of samples showing an antibody level above the indicated threshold of protection. * : p<0.05 (Mann Withney <i>U</i> test).</p