Discovering Shakespeare’s Personal Style: Editing and Connoisseurship in the Eighteenth Century

This chapter examines the use of connoisseurial rhetoric by Shakespeare editors and critics over the course of the eighteenth century, beginning with Alexander Pope in 1723–5 and concluding with George Steevens in the 1780s and 1790s. Connoisseurship was originally developed by art critics as a discourse for authenticating paintings and drawings. Beginning with Pope, however, literary editors began to draw upon it as an analogy for representing authorial style. As I shall show through an examination of Steevens’s work in compiling the first chronological catalogue of William Hogarth’s prints and paintings, this convergence between art criticism and textual criticism involved more than a simple exchange of metaphors. Connoisseurship offered critics such as Steevens new ways of looking at artworks and assessing their genuineness, modes of vision that could be applied as readily to plays as to paintings. The eighteenth-century art market relied upon the expertise of the connoisseur, who could guarantee that a given painting stemmed from the hand of a particular master. Shakespeare publishing in the eighteenth century likewise came to depend on the expertise of the editor, who could reliably identify Shakespeare’s personal style and distinguish the genuine from the spurious

Radicalism in the Margins: The Politics of Reading Wilfrid Scawen Blunt in 1920

This article examines marginalia as a form of radical writing practice in the period immediately after the First World War. It focuses specifically on a densely annotated copy of the second part of Wilfrid Scawen Blunt’s My Diaries, which covers 1900–1914 and was published in 1920. The annotator, John Arthur Fallows (1864–1935), was a former Church of England clergyman and Independent Labour Party politician, and the article asks what motivated him to leave such an explicit record of his engagement with the book in its margins. Blunt recast his original diary entries to show how the outbreak of the First World War had arisen from the pre-war imperialist policies of the Entente. Fallows, meanwhile, used his copy of My Diaries to inscribe a permanent record of his responses to Blunt’s writing, which were shaped by his own memories of pre-war radical-left political action. The dual record of textual engagement that can be recovered from this copy of My Diaries provides insight into how two British radicals “read” the causes of the First World War in the period between the Armistice and the conclusion of the Paris Peace Accords

Reusing Historical Questionnaire Data and Using Newly Commissioned Oral History Interviews as Evidence in the History of Reading

Interviews, whether freestyle or structured, printed or recorded, offer historians of reading valuable insights into the practices and preferences of individual readers. Despite the potential biases that can be generated by the interview format, the reshaping of memory through the process of retelling, and the questions that can go unasked (and therefore, unanswered), the individual interview can be a richly textured source of information for historians of reading. In this article, three researchers involved in both the recently completed Reading Communities: Connecting the Past and the Present project and the ongoing historically focussed UK Reading Experience Database, 1450-1945 project (UK-RED) examine the ways in which interviews can capture individual records of reading, both in the past and the present

Unpacking the “Red Flag” Bookshelf: Negotiating Literary Value on Twitter

On 24 August 2020, the writer Jess McHugh posted on Twitter a list of her “Top 7 Warning Signs in a Man’s Bookshelf”. At the very top of her list of red flags was “A Dogeared copy of Infinite Jest.” This was followed by “Too much Hemingway”, “Any amount of Bukowski”, “AYN. RAND”, and Goethe. Lolita and Ivan Turgenev’s Fathers and Sons also made the cut. McHugh’s tweet quickly went viral across the platform, gaining 3200 replies, 6000 retweets and 17,000 likes over the next four days, as well as news coverage in a variety of venues, including the Onion AV Club and The Times of India. Drawing on platform analysis and qualitative analysis of Twitter data, this article will examine McHugh’s bookshelf meme and some of the many responses—discussions, appropriations and alternative lists, and counter-lists—that it generated (not least from readers of Goethe). It will ask what this episode reveals about the effect of algorithmically curated digital space on understandings of reading, taste, gender, and canonicity in the early 2020s. To what extent do the specific dynamics, affordances, and posting cultures of a virtual platform space like Twitter affect the way “book talk” unfolds online

Readers and Reading in the First World War

This essay consists of three individually authored and interlinked sections. In ‘A Digital Humanities Approach’, Francesca Benatti looks at datasets and databases (including the UK Reading Experience Database) and shows how a systematic, macro-analytical use of digital humanities tools and resources might yield answers to some key questions about reading in the First World War. In ‘Reading behind the Wire in the First World War’ Edmund G. C. King scrutinizes the reading practices and preferences of Allied prisoners of war in Mainz, showing that reading circumscribed by the contingencies of a prison camp created an unique literary community, whose legacy can be traced through their literary output after the war. In ‘Book-hunger in Salonika’, Shafquat Towheed examines the record of a single reader in a specific and fairly static frontline, and argues that in the case of the Salonika campaign, reading communities emerged in close proximity to existing centres of print culture. The focus of this essay moves from the general to the particular, from the scoping of large datasets, to the analyses of identified readers within a specific geographical and temporal space. The authors engage with the wider issues and problems of recovering, interpreting, visualizing, narrating, and representing readers in the First World War

“Medicinable Literature”: Bibliotherapy, Literary Caregiving, and the First World War

Histories of bibliotherapy often emphasize the importance of the First World War in stimulating the development of bibliotherapeutic theory and practice. The word itself was used in a 1916 article by the American author Samuel McChord Crothers, while histories of bibliotherapy in the United Kingdom often foreground H. F. Brett-Smith’s so-called “fever chart” of therapeutic books for treating shell-shocked soldiers. Despite this, however, we argue that a full account of wartime bibliotherapy (particularly the importance of British hospital libraries in its development) has yet to be told. This article draws on the papers of British military hospital personnel to describe the range of “literary caregiving” supporting the treatment of sick and wounded soldiers during the conflict. It traces the social and professional networks underlying these schemes. Finally, it shows how British volunteer librarians helped develop a specifically medicalized language of caregiving through books, thereby contributing to the early development of bibliotherapy

Status of Muon Collider Research and Development and Future Plans

The status of the research on muon colliders is discussed and plans are outlined for future theoretical and experimental studies. Besides continued work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy collider, many studies are now concentrating on a machine near 0.1 TeV (CoM) that could be a factory for the s-channel production of Higgs particles. We discuss the research on the various components in such muon colliders, starting from the proton accelerator needed to generate pions from a heavy-Z target and proceeding through the phase rotation and decay ($\pi \to \mu \nu_{\mu}$) channel, muon cooling, acceleration, storage in a collider ring and the collider detector. We also present theoretical and experimental R & D plans for the next several years that should lead to a better understanding of the design and feasibility issues for all of the components. This report is an update of the progress on the R & D since the Feasibility Study of Muon Colliders presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A. Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics (Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics, Accelerators and Beam

Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease.

PURPOSE: To understand the role of the mitochondrial oxodicarboxylate carrier (SLC25A21) in the development of spinal muscular atrophy-like disease. METHODS: We identified a novel pathogenic variant in a patient by whole-exome sequencing. The pathogenicity of the mutation was studied by transport assays, computer modeling, followed by targeted metabolic testing and in vitro studies in human fibroblasts and neurons. RESULTS: The patient carries a homozygous pathogenic variant c.695A>G; p.(Lys232Arg) in the SLC25A21 gene, encoding the mitochondrial oxodicarboxylate carrier, and developed spinal muscular atrophy and mitochondrial myopathy. Transport assays show that the mutation renders SLC25A21 dysfunctional and 2-oxoadipate cannot be imported into the mitochondrial matrix. Computer models of central metabolism predicted that impaired transport of oxodicarboxylate disrupts the pathways of lysine and tryptophan degradation, and causes accumulation of 2-oxoadipate, pipecolic acid, and quinolinic acid, which was confirmed in the patient's urine by targeted metabolomics. Exposure to 2-oxoadipate and quinolinic acid decreased the level of mitochondrial complexes in neuronal cells (SH-SY5Y) and induced apoptosis. CONCLUSION: Mitochondrial oxodicarboxylate carrier deficiency leads to mitochondrial dysfunction and the accumulation of oxoadipate and quinolinic acid, which in turn cause toxicity in spinal motor neurons leading to spinal muscular atrophy-like disease

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood. Here we show that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages. We find that itaconate directly modifies proteins via alkylation of cysteine residues. Itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream genes with anti-oxidant and anti-inflammatory capacities. The activation of Nrf2 is required for the anti-inflammatory action of itaconate. We describe the use of a new cell-permeable itaconate derivative, 4-octyl itaconate, which is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production. We show that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconate production. Furthermore, we find that itaconate production limits the type I interferon response, indicating a negative feedback loop that involves interferons and itaconate. Our findings demonstrate that itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons

A Comparative Study of the Spatial Distribution of Schistosomiasis in Mali in 1984–1989 and 2004–2006

Geostatistical maps are increasingly being used to plan neglected tropical disease control programmes. We investigated the spatial distribution of schistosomiasis in Mali prior to implementation of national donor-funded mass chemotherapy programmes using data from 1984–1989 and 2004–2006. The 2004–2006 dataset was collected after 10 years of schistosomiasis control followed by 12 years of no control. We found that national prevalence of Schistosoma haematobium and S. mansoni was not significantly different in 2004–2006 compared to 1984–1989 and that the spatial distribution of both infections was similar in both time periods, to the extent that models built on data from one time period could accurately predict the spatial distribution of prevalence of infection in the other time period. This has two main implications: that historic data can be used, in the first instance, to plan contemporary control programmes due to the stability of the spatial distribution of schistosomiasis; and that a decade of donor-funded mass distribution of praziquantel has had no discernable impact on the burden of schistosomiasis in subsequent generations of Malians, probably due to rapid reinfection