Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development

The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed

AUT753563_Supplementary_material – Supplemental material for Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development

<p>Supplemental material, AUT753563_Supplementary_material for Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development by Eric Rubenstein, Lisa D Wiggins, Laura A Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Juhi Pandey, Rebecca Edmondson Pretzel, Annie Green Howard, Andrew F Olshan, Brian W Pence and Julie Daniels in Autism</p

AUT753563_Lay_Abstract – Supplemental material for Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development

<p>Supplemental material, AUT753563_Lay_Abstract for Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development by Eric Rubenstein, Lisa D Wiggins, Laura A Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Juhi Pandey, Rebecca Edmondson Pretzel, Annie Green Howard, Andrew F Olshan, Brian W Pence and Julie Daniels in Autism</p