Additional file 1: Figure S1. of High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study

Study flow chart (PPT 111 kb

Additional file 2: Figure S2. of High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study

Comparison of multivariable logistic-regression derived odds ratios and 95% confidence intervals from all sensitivity analyses, using the complete-case definition (unknown NSAID users excluded), the lower bound definition (unknown NSAID use considered as non-use), and multiple imputation using only participants with an observed outcome (PNG 82 kb

Regional association plots for <i>LHX2</i> and <i>RREB1</i> in GIANT consortium with participants of European ancestry.

<p>The blue arrow points to the index SNPs identified from the samples of African ancestry and red arrow points to the best SNPs in GIANT consortium samples of European ancestry.</p

Interrogation of best SNPs with the smallest p-value within known EA loci in AA for trait WHR ratio adjusted for BMI.

<p>The index SNPs are from Heid et al, Nature Genetics 2010 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen.1003681-Heid1" target="_blank">[17]</a>. Note that <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t003" target="_blank"><b>Tables 3</b></a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>4</b></a> show different information for the same loci (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t003" target="_blank"><b>Table 3</b></a> for index SNP and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a> for best SNPs with the smallest p-value).</p>1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>number of independent (typed) SNPs interrogated in AA sample.</p>4<p>Bonferroni p-value threshold (0.05/N³).</p>5<p>HapMAP LD information.</p>6<p>one-side test p-value.</p>7<p>P_2GC: double GC-corrected p-value.</p

Examination of index SNPs within known loci in EA in AA for trait WHR ratio adjusted for BMI.

<p>The index SNPs is from Heid et al, Nature Genetics 2010 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen.1003681-Heid1" target="_blank">[17]</a>.</p>1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>Significance classification refers to the interrogation results of best SNP in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a>.</p>4<p>p-value of heterogeneity test of beta between EA and AA samples.</p

SNPs associated with waist-related trait at p<5.0E-6 in Stage 1.

1<p>effect allele/other allele.</p>2<p>effect allele frequency.</p>3<p>one-side test p-value.</p>4<p>P_2GC: double GC-corrected p-value.</p

Study sample characteristics.

<p>Study sample characteristics.</p

Cross-trait associations for novel loci from Stage1 + Stage 2 in participants of African ancestry.

1<p>effect allele/other allele.</p>2<p>effect size based on Stage 1 and Stage 2 combined sample.</p

Regional association plots based on single GC-corrected p-value for <i>LHX2</i> and <i>RREB1</i>, Stage 1 only.

<p>MAF = minor allele frequency. The p-values for the index SNP rs2075064 in <i>LHX2</i> loci are 5.5E-8, 0.03, and 2.2E-8 for Stage 1, Stage 2 and joint analysis. The p-values for the index SNP rs6931262 at <i>RREB1</i> loci are 5.3E-8, 0.02 and 2.5E-8 for Stage 1, Stage 2 and joint analysis. The double GC-corrected p-value for the joint analysis are 6.5E-8, 5.7E-8 and 1.8E-6 for rs2075064, rs6931262 and rs1294410, respectively.</p

Regional association plots for all confirmed loci from the GIANT locus interrogation.

<p>Each figure is centered by the index SNP (big red) with rs-number and p-value information (stage 1 only); another big rectangle is the best SNP in African Americans, with information including MAF = minor allele frequency; linkage disequilibrium information in HapMap YRI and CEU<i>; P_D, P_F, and P_J</i> are the single GC-corrected p-value obtained from discovery cohorts only, follow-up cohorts and joint discovery and follow-up data, respectively. Double GC-corrected p-value can be found in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003681#pgen-1003681-t004" target="_blank"><b>Table 4</b></a>.</p