Effect of strontium ranelate on fracture healing in rat tibia

In the present study, we were unable to find any beneficial or harmful effects of strontium ranelate on fracture healing. (C) 2007 Elsevier Masson SAS. All rights reserved

Radioiodine ablation treatment induced pill esophagitis: A case report

Capsule form of the drugs is more risk for pill-induced esophagitis. Radioiodine ablation is recommended for well differentiated thyroid cancer primary tumors >1 cm in diameter. In ablation, it is aimed to "ablate" the remaining healthy thyroid tissue. We present a case of a 23-year-old woman with complaints of severe odynophagia, dysphagia and retrosternal pain 3 days in which radioiodine ablation treatment was the cause of pill-induced esophagitis. She complained after she had undergone to radioiodine ablation treatment for papillary thyroid carcinoma. She had a history of swallowing I-131 capsule with about 150 ml water in the upright position. An upper endoscopic examination demonstrated two superficial kissing ulcers about 1 cm diameter in the middle of the esophagus. Pantoprazole and sucralfate treatment was started. Symptoms improved seven days after starting this treatment. The esophagus was completely normal in control endoscopy after two weeks. Radioiodine ablation treatment with I-131 capsule may cause esophageal lesions; therefore, patients should be educated by nuclear medicine physicians about the possible side effects of this treatment

Radioiodine Ablation Treatment Induced Pill Esophagitis: A Case Report

Capsule form of the drugs is more risk for pill-induced esophagitis. Radioiodine ablation is recommended for well differentiated thyroid cancer primary tumors >1 cm in diameter. In ablation, it is aimed to ablate the remaining healthy thyroid tissue. We present a case of a 23-year-old woman with complaints of severe odynophagia, dysphagia and retrosternal pain 3 days in which radioiodine ablation treatment was the cause of pill-induced esophagitis. She complained after she had undergone to radioiodine ablation treatment for papillary thyroid carcinoma. She had a history of swallowing I-131 capsule with about 150 ml water in the upright position. An upper endoscopic examination demonstrated two superficial kissing ulcers about 1 cm diameter in the middle of the esophagus. Pantoprazole and sucralfate treatment was started. Symptoms improved seven days after starting this treatment. The esophagus was completely normal in control endoscopy after two weeks. Radioiodine ablation treatment with I-131 capsule may cause esophageal lesions; therefore, patients should be educated by nuclear medicine physicians about the possible side effects of this treatment

The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors

Objective: Tumor-associated tissue eosinophilia (TATE)has been noted in human cancers, sometimes with differentresults regarding their association with clinical outcome.In this study, the association between TATE andprognostic parameters of supraglottic laryngeal cancerwas analyzed.Materials and methods: Sixty-two patients with diagnosisof supraglottic laryngeal squamous cell carcinoma andwho treated surgically in our center were evaluated. Thecases were divided into 3 categories according to the averagenumber of eosinophils per high-power field (400x):0 (negative), 1-5 (grade 1+), more than 5 (grade 2+).Results: We found 24 TATE-negative (38.7%) and 38TATE-positive (61.3%) cases. There was not any statisticallysignificant correlation between TATE and tumor differentiation,vascular invasion, perineural invasion, lymphnode metastasis, patients’ ages, T stages (p>0.05). Asexpected, vascular invasion correlated with lymph nodemetastasis (p=0.001).Conclusion: The results of this study showed that TATEhas no correlation with prognostic parameters such ashistologic differentiation, vascular invasion, perineuralinvasion, lymph node metastasis, patients’ ages and Tstages in supraglottic laryngeal squamous cell carcinoma.The data suggest that stromal eosinophilic infiltrationis not useful for determining biological aggressiveness insupraglottic laryngeal cancer.Key words: laryngeal carcinoma, supraglottic, eosinophilia,prognostic parameter

Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis

AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of cerulean-induced acute pancreatitis (AP)

The beneficial effect of propolis on cerulein-induced experimental acute pancreatitis in rats

Background/aims: Inflammatory cytokitzes and oxidative stress have a central role in the pathogenesis of acute pancreatitis. Propolis is a resinous hive product collected by honeybees from various plant sources and has anti-inflammatory and anti-oxidant effects. The present work aimed to investigate the therapeutic role of ethanolic extract of propolis on a cerulein-induced acute pancreatitis model in rats. Methods: Seventy male Wistar albino rats were used in the study. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 mu g/kg) four times at one-hour intervals. Ethanolic extract of propolis 300 mg/kg was given subcutaneously at the beginning of the procedure (ethanolic extract of propolis-1 group) or 12 h after the last cerulein injection (ethanolic extract of propolis-2 group). Serum amylase and lipase levels, white blood cell count and serum tumor necrosis factor-alpha levels were measured and pancreatic tissue was evaluated histologically. Results: In the acute pancreatitis group, serum amylase and lipase levels were found to be elevated and the histopathological evaluation of the tissue revealed massive edema and inflammation with less fatty necrosis when compared to the sham and control groups. Serum amylase and lipase levels and edema formation were significantly decreased in the ethanolic extract of propolis-treated groups (p<0.001). In the ethanolic extract of propolis-2 group, in particular, tissue edema was improved markedly (p=0.001). Tissue inflammation and fatty necrosis were decreased with ethanolic extract of propolis treatment; however, the improvement was not statistically significant. Conclusions: Treatment with ethanolic extract of propolis improved the biochemical and histopathological findings in a rat model of experimental pancreatitis. Although our findings suggest that ethanolic extract of propolis might be considered an effective agent for the treatment of acute pancreatitis, this notion should be supported with further experimental and clinical investigations

Effectiveness of Palosuran in Bleomycin-Induced Experimental Scleroderma

Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study was to evaluate the effects of urotensin-II (U-II) antagonist palosuran in an animal model of scleroderma. We also planned to measure U-II, endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-beta 1) levels, as well as the association of these levels with dermal thickness. Twenty-four male mice were included in this study and they were divided into three groups-group 1: control group, group 2: fibrosis group, and group 3: fibrosis + palosuran treatment group. Fibrosis + palosuran treatment in group 3 reduced ET-1, U-II, and TGF-beta 1 levels. In total, the diminished values were statistically significant in the ET-1 and TGF-beta 1 levels (p 0.05). It is believed that U-II is an important mediator in SSc, and its antagonism with palosuran could be a new treatment choice in SSc