The Association Between Anthropometric Findings and Hormonal Values in Obese and Overweight Children

INTRODUCTION: Obesity is an energy metabolism disorder that occurs with excessive fat storage in the body and can cause physical and mental problems. In this study; It was aimed to investigate the relationship between anthropometric findings and hormonal values in obese and overweight children. METHODS: The data was retrospectively collected by reviewing the files of 742 children with obesity and overweight diagnoses who were followed up in Pediatric Endocrinology Clinic between 2010-2011. For all cases age, gender and anthropometric measurements are recorded. Fasting blood glucose, insulin, c-peptite, total cholesterol, trigliseride, LDL-cholesterol, VLDL cholesterol, HDL cholesterol, IGF-1 and IGFBP3 values are evaluated. Insulin resistance is calculated by HOMA-IR RESULTS: Of those included in the study, 534 were obese and 208 were overweight. In pubertal period, an increase in HOMA-IR and fasting insulin levels was observed in obese group compared to overweight group. In the prepubertal period, no significant difference was observed between obese and overweight groups in terms of bone age, while in the obese group, bone age was significantly higher in the pubertal period than in overweight group. At the same time the bone age in obese children with BMI and body weight were found to be significantly correlated in a positive direction. DISCUSSION AND CONCLUSION: Considering that obesity and overweight increase growth rate and bone maturation, decrease growth rate in puberty, short target length, dyslipidemia and future cardiovascular complications, it is very important to prevent childhood obesity in the early period

Impact of the COVID-19 pandemic on diabetic ketoacidosis management in the pediatric intensive care unit

Background Diabetic ketoacidosis (DKA) is a common endocrine emergency in pediatric patients. Early presentation to health facilities, diagnosis, and good management in the pediatric intensive care unit (PICU) are crucial for better outcomes in children with DKA. Methods This was a single-center, retrospective cohort study conducted between February 2015 and January 2022. Patients with DKA were divided into two groups according to pandemic status and diabetes diagnosis. Results The study enrolled 59 patients, and their mean age was 11±5 years. Forty (68%) had newly diagnosed type 1 diabetes mellitus (T1DM), and 61% received follow-up in the pre-pandemic period. Blood glucose, blood ketone, potassium, phosphorus, and creatinine levels were significantly higher in the new-onset T1DM group compared with the previously diagnosed group (P=0.01, P=0.02, P<0.001, P=0.01, and P=0.08, respectively). In patients with newly diagnosed T1DM, length of PICU stays were longer than in those with previously diagnosed T1DM (28.5±8.9 vs. 17.3±6.7 hours, p<0.001). The pandemic group was compared with pre-pandemic group, there was a statistically significant difference in laboratory parameters of pH, HCO3, and lactate and also Pediatric Risk of Mortality (PRISM) III score. All patients survived, and there were no neurologic sequelae. Conclusion Patients admitted during the pandemic period were admitted with more severe DKA and had higher PRISM III scores. During the pandemic period, there was an increase in the incidence of DKA in the participating center compared to that before the pandemic

Multisystem Inflammatory Syndrome in Children Admitted to a Tertiary Pediatric Intensive Care Unit

Background Multisystem inflammatory syndrome in children (MIS-C) is characterized by persistent fever, abdominal pain, vomiting, diarrhea, rash, conjunctivitis, headaches, and mucocutaneous manifestations and it can cause circulatory dysfunction, resulting in hypotension, shock, and end-organ injury in the heart and other organs and possibly death. In this study, we aimed to analyze the clinical spectrum, treatment options and outcomes of children with MIS-C who were admitted to our pediatric intensive care (PICU)