1,753 research outputs found
Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.
In all mammals, the sensory epithelium for audition is located along the spiraling organ of Corti that resides within the conch shaped cochlea of the inner ear (fig 1). Hair cells in the developing cochlea, which are the mechanosensory cells of the auditory system, are aligned in one row of inner hair cells and three (in the base and mid-turns) to four (in the apical turn) rows of outer hair cells that span the length of the organ of Corti. Hair cells transduce sound-induced mechanical vibrations of the basilar membrane into neural impulses that the brain can interpret. Most cases of sensorineural hearing loss are caused by death or dysfunction of cochlear hair cells
Transverse Demagnetization Dynamics of a Unitary Fermi Gas
Understanding the quantum dynamics of strongly interacting fermions is a
problem relevant to diverse forms of matter, including high-temperature
superconductors, neutron stars, and quark-gluon plasma. An appealing benchmark
is offered by cold atomic gases in the unitary limit of strong interactions.
Here we study the dynamics of a transversely magnetized unitary Fermi gas in an
inhomogeneous magnetic field. We observe the demagnetization of the gas, caused
by diffusive spin transport. At low temperatures, the diffusion constant
saturates to the conjectured quantum-mechanical lower bound ,
where is the particle mass. The development of pair correlations,
indicating the transformation of the initially non-interacting gas towards a
unitary spin mixture, is observed by measuring Tan's contact parameter.Comment: 8 pages, 6 figures. Accepted versio
The Dwarf Irregular Galaxy UGC 7636 Exposed: Stripping At Work In The Virgo Cluster
We present the results of optical spectroscopy of a newly discovered H II
region residing in the H I gas cloud located between the dwarf irregular galaxy
UGC 7636 and the giant elliptical galaxy NGC 4472 in the Virgo Cluster. By
comparing UGC 7636 with dwarf irregular galaxies in the field, we show that the
H I cloud must have originated from UGC 7636 because (1) the oxygen abundance
of the cloud agrees with that expected for a galaxy with the blue luminosity of
UGC 7636, and (2) M_{H I}/L_B for UGC 7636 becomes consistent with the measured
oxygen abundance of the cloud if the H I mass of the cloud is added back into
UGC 7636. It is likely that tides from NGC 4472 first loosened the H I gas,
after which ram-pressure stripping removed the gas from UGC 7636.Comment: 12 pages, 2 eps figures (AASTeX 5.0); accepted for publication in ApJ
Letter
Constraints on Type Ia Supernova Models from X-ray Spectra of Galaxy Clusters
We present constraints on theoretical models of Type Ia supernovae using
spatially resolved ASCA X-ray spectroscopy of three galaxy clusters: Abell 496,
Abell 2199 and Abell 3571. All three clusters have central iron abundance
enhancements; an ensemble of abundance ratios are used to show that most of the
iron in the central regions of the clusters comes from SN Ia. These
observations are consistent with the suppressed galactic wind scenario proposed
by Dupke and White (1999). At the center of each cluster, simultaneous analysis
of spectra from all ASCA instruments shows that the nickel to iron abundance
ratio (normalized by the solar ratio) is Ni/Fe ~ 4. We use the nickel to iron
ratio as a discriminator between SN Ia explosion models: the Ni/Fe ratio of
ejecta from the "Convective Deflagration" model W7 is consistent with the
observations, while those of "delayed detonation" models are not consistent at
the 90% confidence level.Comment: 20 pages, 2 figures, accepted by The Astrophysical Journa
Measuring the mean and scatter of the X-ray luminosity -- optical richness relation for maxBCG galaxy clusters
Determining the scaling relations between galaxy cluster observables requires
large samples of uniformly observed clusters. We measure the mean X-ray
luminosity--optical richness (L_X--N_200) relation for an approximately
volume-limited sample of more than 17,000 optically-selected clusters from the
maxBCG catalog spanning the redshift range 0.1<z<0.3. By stacking the X-ray
emission from many clusters using ROSAT All-Sky Survey data, we are able to
measure mean X-ray luminosities to ~10% (including systematic errors) for
clusters in nine independent optical richness bins. In addition, we are able to
crudely measure individual X-ray emission from ~800 of the richest clusters.
Assuming a log-normal form for the scatter in the L_X--N_200 relation, we
measure \sigma_\ln{L}=0.86+/-0.03 at fixed N_200. This scatter is large enough
to significantly bias the mean stacked relation. The corrected median relation
can be parameterized by L_X = (e^\alpha)(N_200/40)^\beta 10^42 h^-2 ergs/s,
where \alpha = 3.57+/-0.08 and \beta = 1.82+/-0.05. We find that X-ray selected
clusters are significantly brighter than optically-selected clusters at a given
optical richness. This selection bias explains the apparently X-ray
underluminous nature of optically-selected cluster catalogs.Comment: 21 pages, 12 figures, revised after referee's comments. ApJ accepte
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Spiral Ganglion Stem Cells Can Be Propagated and Differentiated Into Neurons and Glia
Abstract The spiral ganglion is an essential functional component of the peripheral auditory system. Most types of hearing loss are associated with spiral ganglion cell degeneration which is irreversible due to the inner ear's lack of regenerative capacity. Recent studies revealed the existence of stem cells in the postnatal spiral ganglion, which gives rise to the hope that these cells might be useful for regenerative inner ear therapies. Here, we provide an in-depth analysis of sphere-forming stem cells isolated from the spiral ganglion of postnatal mice. We show that spiral ganglion spheres have characteristics similar to neurospheres isolated from the brain. Importantly, spiral ganglion sphere cells maintain their major stem cell characteristics after repeated propagation, which enables the culture of spheres for an extended period of time. In this work, we also demonstrate that differentiated sphere-derived cell populations not only adopt the immunophenotype of mature spiral ganglion cells but also develop distinct ultrastructural features of neurons and glial cells. Thus, our work provides further evidence that self-renewing spiral ganglion stem cells might serve as a promising source for the regeneration of lost auditory neurons
The binary period and outburst behaviour of the SMC X-ray binary pulsar system SXP504
A probable binary period has been detected in the optical counterpart to the
X-ray source CXOU J005455.6-724510 = RX J0054.9-7245 = AXJ0054.8-7244 = SXP504
in the Small Magellanic Cloud. This source was detected by Chandra on 04 Jul
2002 and subsequently observed by XMM-Newton on 18 Dec 2003. The source is
coincident with an Optical Gravitational Lensing (OGLE) object in the
lightcurves of which several optical outburst peaks are visible at ~ 268 day
intervals. Timing analysis shows a period of 268.6 +/- 0.1 days at > 99%
significance. Archival Rossi X-ray Timing Explorer (RXTE) data for the 504s
pulse-period has revealed detections which correspond closely with predicted or
actual peaks in the optical data. The relationship between this orbital period
and the pulse period of 504s is within the normal variance found in the Corbet
diagram.Comment: Accepted by MNRAS. 1 LATEX page. 4 figure
Magnetic fields in cluster cores: Faraday rotation in A400 and A2634
We present Faraday rotation data for radio sources in the centers of the
Abell clusters A400 and A2634. These clusters contain large (> 100 kpc), tailed
radio sources, each attached to the central cD galaxy. These clusters do not
have strong cooling cores. Our data extend previous work on rotation measure in
cluster centers to larger scales and non-cooling clusters. The rotation
measure, and thus the magnetic field, is ordered on scales 10-20 kpc in both
clusters. The geometry of the rotation measure appears to be determined by the
distribution of the X-ray emitting gas, rather than by the radio tails
themselves. We combine our data with previously published X-ray and radio data
in order to analyze the magnetic fields in all 12 clusters whose central radio
sources have been imaged in rotation measure. We find that the fields are
dynamically significant in most clusters. We argue that the Faraday data
measure fields in the intracluster medium, rather than in a skin of the radio
source. Finally, we consider the nature and maintenance of the magnetic fields
in these clusters, and conclude that either the cluster-wide field exists at
similar levels, or that a weaker cluster-wide field is amplified by effects in
the core.Comment: Accepted for ApJ. 43 pages including 10 embedded figures. Higher
resolution versions of the figures available at
http://www.aoc.nrao.edu/~jeilek/pubs/Eilekpub.htm
The Mass Function of an X-Ray Flux-Limited Sample of Galaxy Clusters
A new X-ray selected and X-ray flux-limited galaxy cluster sample is
presented. Based on the ROSAT All-Sky Survey the 63 brightest clusters with
galactic latitude |bII| >= 20 deg and flux fx(0.1-2.4 keV) >= 2 * 10^{-11}
ergs/s/cm^2 have been compiled. Gravitational masses have been determined
utilizing intracluster gas density profiles, derived mainly from ROSAT PSPC
pointed observations, and gas temperatures, as published mainly from ASCA
observations, assuming hydrostatic equilibrium. This sample and an extended
sample of 106 galaxy clusters is used to establish the X-ray
luminosity--gravitational mass relation. From the complete sample the galaxy
cluster mass function is determined and used to constrain the mean cosmic
matter density and the amplitude of mass fluctuations. Comparison to
Press--Schechter type model mass functions in the framework of Cold Dark Matter
cosmological models and a Harrison--Zeldovich initial density fluctuation
spectrum yields the constraints OmegaM = 0.12^{+0.06}_{-0.04} and sigma8 =
0.96^{+0.15}_{-0.12} (90% c.l.). Various possible systematic uncertainties are
quantified. Adding all identified systematic uncertainties to the statistical
uncertainty in a worst case fashion results in an upper limit OmegaM < 0.31.
For comparison to previous results a relation sigma8 = 0.43 OmegaM^{-0.38} is
derived. The mass function is integrated to show that the contribution of mass
bound within virialized cluster regions to the total matter density is small,
i.e., OmegaCluster = 0.012^{+0.003}_{-0.004} for cluster masses larger than
6.4^{+0.7}_{-0.6} * 10^{13} h_{50}^{-1} Msun.Comment: 35 pages; accepted for publication in The Astrophysical Journal; this
and related papers, supplementary information, as well as electronic files of
the tables given in this paper are available at
http://www.astro.virginia.edu/~thr4f
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Sox2 in the differentiation of cochlear progenitor cells
HMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiation, through an interaction with the 3âČ enhancer of Atoh1. Binding to consensus sequences in the Atoh1 enhancer was dependent on the level of Sox2, and the extent of enhancer binding correlated to the extent of activation. Atoh1 activation by Sox2 was required for embryonic hair cell development: deletion of Sox2 in an inducible mutant, even after progenitor cells were fully established, halted development of hair cells, and silencing also inhibited postnatal differentiation of hair cells induced by inhibition of Îł-secretase. Sox2 is thus required in the cochlea to both expand the progenitor cells and initiate their differentiation to hair cells
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