TLRS-3 system upgrades

This presentation describes the upgrades to the Transportable Laser Ranging Systems serial number three (TLRS-3), and the impact that these upgrades will have on the TLRS-3 performance in the field. The four major areas of system upgrades are the HP-380 computer, the Optical Attenuation Mechanism (OAM), the upgraded spatial, spectral and temporal filtering for improved daylight ranging capability, and the software upgrade to enable the system to track the Etalon satellites. The TLRS-3 was returned to the Goddard Geophysical and Astronomical Observatory (GGAO) in December 1991 for system upgrades in preparation of the TOPEX/POSEIDON campaign scheduled to begin in the summer of 1992. Many system upgrades were incorporated into the system while interleaving planned facility maintenance making TLRS-3 a more versatile and more dependable laser ranging system. The TLRS-3 was initially baselined with the MOBLAS-7 via simultaneous satellite ranging on the LAGEOS, Ajisai, Starlette, and ERS-I satellites. During the upgrades and following completion of the system upgrades intercomparisons with the MOBLAS-7 were made to verify the integrity and accuracy of the system changes. Several other groups of personnel participated in the TLRS-3 upgrade and they are: the Survey Section, the Precision Measurement Equipment Laboratory, the Architectural and Engineering Services Department, the Precision Timing Section, and the station personnel at TLRS-3 and MOBLAS-7

A propofol binding site on mammalian GABAA receptors identified by photolabeling

Propofol is the most important intravenous general anesthetic in current clinical use. It acts by potentiating GABA(A) receptors, but where it binds to this receptor is not known and has been a matter of some controversy. We have synthesized a novel propofol analogue photolabeling reagent that has a biological activity very similar to that of propofol. We confirmed that this reagent labeled known propofol binding sites in human serum albumin which have been identified using X-ray crystallography. Using a combination of the protiated label and a deuterated version, and mammalian receptors labeled in intact membranes, we have identified a novel binding site for propofol in GABA(A) receptors consisting of both β(3) homopentamers and α(1)β(3) heteropentamers. The binding site is located within the β subunit, at the interface between the transmembrane domains and the extracellular domain, and lies close to known determinants of anesthetic sensitivity in transmembrane segments TM1 and TM2

Discrimination in the Doctor’s Office: Immigrants and Refugee Experiences

There is a growing awareness of the role played by discrimination in the provision of health care services to immigrants and refugees across Canada. Very little research, however, has explored how perceived discrimination influences patient relationships with health care providers and the health care system in Ontario. This qualitative study documents perceptions of discrimination from a service user perspective in five small and medium-sized Ontario cities. Results of 26 interviews with immigrants and refugees highlight the complex nature and impacts of discrimination in shaping newcomer experiences as a basis for developing effective public policy in health care and social services