Resources for Chemistry Teaching in Secondary Schools in Akwa Ibom State, Nigeria

This study investigated the status of human and material resources for effective implementation of the new chemistry curriculum for secondary schools in Nigeria in Akwa Ibom state. To achieve the objectives of the study, two research questions were raised. Ex-post-facto design was used. The sample consisted of 105 chemistry teachers from all the 31 local government areas of the state using criterion sampling technique. A researcher-developed questionnaire, Resources for Chemistry Teaching Questionnaire (RCTQ), with a reliability index of 0.83 determined using Cronbach’s alpha reliability formula, was used in collecting relevant data. The results of data analyses using percentage rating showed that available human resources are not equitably distributed; the basic facilities are either lacking or are grossly inadequate; and the basic chemicals and equipment for students’ activities are either lacking or are grossly inadequate. Consequently, it was been recommended that the state government should urgent steps to ensure successful implementation of the new curriculum in the state

Adopting Information and Communication Technologies for Effective Inclusive Education

Education had been identified and used the world over, as the most dynamic tool to achieve societal change. Over the centuries, it has been consistently used to achieve behavioural change and make man useful to himself and his society. However, it has been observed that formal education tends to exclude children and adults who have physical, emotional, intellectual, psychological, locational, linguistic and other challenges. Whereas for education to maximally achieve its objectives, it has to be inclusive. Inclusive education implies an educational system which must include disabled and gifted children, children from remote and nomadic population, street and working children, children from linguistic, ethnic, or cultural minorities as well as children and adults who are disadvantaged or marginalized. To this end, there arise a need to meet the need of every learner and ensure that no one is left out during an instructional exercise. Based on the dynamism of Information and Communication Technologies (ICTs) in education, the writers believe strongly that, if educational ICTs are appropriately adopted and effectively utilized, the challenges of inclusive education could be mitigated. This paper therefore takes a look at the definition, coverage, benefits and challenges of inclusive education. It x-rays ICTs and points out the necessary ICT tools for inclusive education. It outlines the benefits and challenges associated with the effective use of ICTs in inclusive education. Finally, the paper makes replicable recommendations for effective engagement of ICTs in inclusive education for enhanced efficiency. Keywords: Inclusive education, Marginalized, Technological gadgets, Modern ICTs DOI: 10.7176/JEP/11-24-16 Publication date:August 31st 202

Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones

The antibacterial activities of a series of triazolyl oxazolidinones against Mycobacterium tuberculosis strain in vitro and in vivo in a mice model are presented. Most active compounds were noncytotoxic against VERO cells with acceptable selectivity indexes (SI) as measures of compound tolerability. Structure activity relationships (SARs) revealed that analogs with alkylcarbonyl (IC90: < 0.2 to 0.422 μg/mL) and arylcarbonyl (IC90: < 0.2 to 2.103 μg/mL) groups at the piperazine 4N-position-displayed potent antimycobacterium activities, comparable to the methanesulfonyl (IC90: < 0.2 μg/mL) analog, linezolid (IC90: < 0.2 μg/mL), and isoniazid (IC90: < 0.034 μg/mL). The furanylcarbonyl derivative also displayed potent activity, while the arylsulfonyl analogs were inactive. Of the triazolyl oxazolidinones, the morpholino (PH-27) derivative with medium bioavailability in plasma was most active in vivo, but relatively less efficacious than isoniazid

The prevalence of antimicrobial resistance and carriage of virulence genes in Staphylococcus aureus isolated from food handlers in Kuwait City restaurants

<p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus </it>is a major cause of food poisoning due to their ability to produce enterotoxins which if ingested in sufficient amounts results in sickness. Food handlers carrying enterotoxin-producing <it>S. aureus </it>in their noses or hands can contaminate food leading to food poisoning. We characterized 200 <it>S. aureus </it>obtained from food handlers in different restaurants for antibacterial resistance and the carriage of virulence genes.</p> <p>Findings</p> <p>Susceptibility to antibacterial agents was determined by disk diffusion and Etest. PCR was used to detect genes for accessory gene regulator (agr); capsular polysaccharide (cap) 5 and 8, staphylococcal enterotoxins (SE), toxic shock syndrome toxin-1 (TSST-1) and Panton-Valentine leukocidin (PVL). Isolates were typed using pulsed-field gel electrophoresis. In total 185 (92.5%) of the 200 isolates expressed resistance to antibacterial agents. They were resistant to penicillin G (82.0%), tetracycline (19.0%), erythromycin (2.5%), clindamycin (2.0%), trimethoprim (7.5%), kanamycin (2.5%), streptomycin (1.5%), ciprofloxacin (1.5%), fusidic acid (1.0%) and cadmium acetate (68.0%). Seventy-six (38.0%) and 114 (57.0%) isolates had type 5 and type 8 capsular polysaccharides respectively. The agr types I, II and III alleles were detected in 50.5%, 20.0% and 23.5% of the isolates respectively. They contained genes for SEI (38.5%), SEG (24.0%), SEC (23.0%), SEB (12.5%), SEH (21.5%), SEA (11.0), SED (1.5%), SEE (1.5%), TSST-1 (4.0%) and PVL (9.0%).</p> <p>Conclusion</p> <p>This study revealed a high prevalence of antibacterial resistance and virulence determinants in <it>S. aureus </it>from food handlers in Kuwait restaurants justifying the screening of food handlers to detect and treat carriers and protect restaurant customers from staphylococcal food poisoning.</p

Checkmating the Weaknesses Associated with Information and Communication Technologies in Education for Improved Effectiveness and Efficiency

Information and Communication Technologies (ICTs) have been identified as having two sides like a coin when used instructionally. While some scholars insist on the need to always prepare and deliver instructions using ICTs, others express worries over the pedagogical weaknesses thereof. This paper therefore x-rays the instructional strengths of ICTs to include; improving educational quality, enhancing access to education, easing collaboration, motivating learning, provision of remote learning resources, enhancing technological literacy, amongst others. It further enumerates the weaknesses of ICTs in teaching and learning to include high cost of acquiring and maintaining infrastructure and equipment, creation of inequality among learners, causing distraction among learners, encouraging cheating in examination and during assignments, exposing learners to technological hazards, inter alia. The paper proffers recommendations on how to effectively engage ICTs in teaching – learning to maximize the potentials, amongst which are: adequate funding for ICT sector in every educational institution; identification of needs, goals and objectives; proper budgeting and planning; engaging stakeholders for awareness and getting their inputs; ensuring safe and conducive environmental setting for the equipment; carrying out periodic employment, training and re-training of man-power; putting in place robust plagiarism software to checkmate theft of intellectual property; and providing detailed orientation for learners who are the end-users of the ICTs in the classrooms. Keywords: Checkmating, Weaknesses, ICTs, Effectiveness, Efficiency. DOI: 10.7176/JEP/12-8-11 Publication date:March 31st 202

Portfolio Analysis Models: A Review

This study, which is qualitative in nature, examined the concept of portfolio analysis with focus on business portfolio analysis. Four portfolio analysis models: Boston Consulting growth-share matrix, General Electric industry-attractiveness matrix, Shell directional policy matrix, and Arthur D. Little strategic condition matrix, were discussed in terms of their nature, characteristics, relevance and strategic implications to marketing and management. The limitations of each of these strategic tools were expounded and some newer variants of portfolio analysis models that emerged as a result of these limitations were briefly discussed. The study revealed that each of the four portfolio models has its own merits and demerits and none can be said to be superior as their proponents had advanced.  Instead, each can be applied depending on the need of the organization and the environment in which it operates and they could sometime be employed in an integrative manner. It also revealed that the newer variants though theoretically sound are not popular in marketing and management literatures and in practice.  The study concluded that most of the criticisms leveled against these strategic tools are as a result of the misplaced role these tools are expected to play.  Portfolio analysis, the study concluded is not to dictate or recommend strategic decision but to provide strategists with the data needed to making informed decision. Keywords: Portfolio analysis, Boston Consulting growth-share matrix, General Electric industry-attractiveness matrix, Shell directional policy matrix, Arthur D. Little strategic condition matri

Prevalence of Hypertension in Akwa Ibom State, South-South Nigeria: Rural versus Urban Communities Study

Recent studies have shown an increasing trend in the prevalence of hypertension in rural communities compared to that of the urban communities. This study was therefore carried out to determine the prevalence of hypertension and its predictors (if any) in both urban and rural communities of Akwa Ibom State of Nigeria. Subjects and Method. This was a cross-sectional study of urban and rural communities of Akwa Ibom State for the prevalence of hypertension and its predictors. Two urban cities and two rural communities were randomly selected from the three senatorial districts of the state. Hypertension was defined based on the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of Hypertension. Results. Nine hundred and seventy-eight (978) participants were recruited from rural areas and five hundred and ninety (590) from urban centers. The rural populace had higher systolic, diastolic, and mean arterial blood pressure than the urban populace ( &lt; 0.001, &lt; 0.002, &lt; 0.001, resp.). The prevalence of hypertension was significantly higher in the rural populace than in the urban populace [44.3% (95% CI 41.1-47.4%) versus 28.6% (95% CI 24.9-32.3%)]. Age, BMI, and proteinuria were independent predictors of hypertension occurrence. Conclusion. There is an epidemiologic change in the prevalence of hypertension in the rural communities of Nigeria

Prevalence of Hypertension in Akwa Ibom State, South-South Nigeria: Rural versus Urban Communities Study

Recent studies have shown an increasing trend in the prevalence of hypertension in rural communities compared to that of the urban communities. This study was therefore carried out to determine the prevalence of hypertension and its predictors (if any) in both urban and rural communities of Akwa Ibom State of Nigeria. Subjects and Method. This was a cross-sectional study of urban and rural communities of Akwa Ibom State for the prevalence of hypertension and its predictors. Two urban cities and two rural communities were randomly selected from the three senatorial districts of the state. Hypertension was defined based on the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of Hypertension. Results. Nine hundred and seventy-eight (978) participants were recruited from rural areas and five hundred and ninety (590) from urban centers. The rural populace had higher systolic, diastolic, and mean arterial blood pressure than the urban populace (P<0.001, < 0.002, < 0.001, resp.). The prevalence of hypertension was significantly higher in the rural populace than in the urban populace [44.3% (95% CI 41.1–47.4%) versus 28.6% (95% CI 24.9–32.3%)]. Age, BMI, and proteinuria were independent predictors of hypertension occurrence. Conclusion. There is an epidemiologic change in the prevalence of hypertension in the rural communities of Nigeria

Antibacterial resistance and their genetic location in MRSA isolated in Kuwait hospitals, 1994-2004

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major cause of serious infections in hospitals and in the community worldwide. In this study, MRSA isolated from patients in Kuwait hospitals were analyzed for resistance trends and the genetic location of their resistance determinants. METHODS: Between April 1994 and December 2004, 5644 MRSA isolates obtained from different clinical samples were studied for resistance to antibacterial agents according to guidelines from the National Committee for Clinical Laboratory Standards and the British Society for Antimicrobial Chemotherapy. The genetic location of their resistance determinants was determined by curing and transfer experiments. RESULTS: They were resistant to aminoglycosides, erythromycin, tetracycline, trimethoprim, fusidic acid, ciprofloxacin, chloramphenicol, rifampicin, mupirocin, cadmium acetate, mercuric chloride, propamidine isethionate and ethidium bromide but susceptible to vancomycin, teicoplanin and linezolid. The proportion of the isolates resistant to erythromycin, ciprofloxacin and fusidic acid increased during the study period. In contrast, the proportion of isolates resistant to gentamicin, tetracycline, chloramphenicol and trimethoprim declined. High-level mupirocin resistance increased rapidly from 1996 to 1999 and then declined. They contained plasmids of 1.9, 2.8, 3.0, 4.4, 27 and 38 kilobases. Genetic studies revealed that they carried plasmid-borne resistance to high-level mupirocin resistance (38 kb), chloramphenicol (2.8 – 4.4 kb), erythromycin (2.8–3.0 kb) and cadmium acetate, mercuric chloride, propamidine isethionate and ethidium bromide (27 kb) and chromosomal location for methicillin, the aminoglycosides, tetracycline, fusidic acid, ciprofloxacin and trimethoprim resistance. Thus, the 27 kb plasmids had resistance phenotypes similar to plasmids reported in MRSA isolates in South East Asia. CONCLUSION: The prevalence of resistance to erythromycin, ciprofloxacin, high-level mupirocin and fusidic acid increased whereas the proportion of isolates resistant to gentamicin, tetracycline, chloramphenicol and trimethoprim declined during the study period. They contained 27-kb plasmids encoding resistance to cadmium acetate, mercuric chloride, propamidine isethionate and ethidium bromide similar to plasmids isolated in MRSA from South East Asia. Molecular typing of these isolates will clarify their relationship to MRSA from South East Asia

Phenotypic and molecular characterization of Staphylococcus aureus isolates expressing low- and high-level mupirocin resistance in Nigeria and South Africa

<p>Abstract</p> <p>Background</p> <p>Mupirocin is a topical antimicrobial agent which is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of methicillin-resistant <it>Staphylococcus aureus </it>(MRSA). However, the prevalence of mupirocin resistance in <it>S. aureus</it>, particularly in MRSA, has increased with the extensive and widespread use of this agent in hospital settings. This study characterized low- and high-level mupirocin-resistant <it>S. aureus </it>isolates obtained from Nigeria and South Africa.</p> <p>Methods</p> <p>A total of 17 mupirocin-resistant <it>S. aureus </it>isolates obtained from two previous studies in Nigeria and South Africa, were characterized by antibiogram, PCR-RFLP of the coagulase gene and PFGE. High-level mupirocin resistant isolates were confirmed by PCR detection of the <it>mupA </it>gene. The genetic location of the resistance determinants was established by curing and transfer experiments.</p> <p>Results</p> <p>All the low-level mupirocin resistant isolates were MRSA and resistant to gentamicin, tetracycline and trimethoprim. PFGE identified a major clone in two health care institutions located in Durban and a health care facility in Pietermaritzburg, Greytown and Empangeni. Curing and transfer experiments indicated that high-level mupirocin resistance was located on a 41.1 kb plasmid in the South African strain (A15). Furthermore, the transfer of high-level mupirocin resistance was demonstrated by the conjugative transfer of the 41.1 kb plasmid alone or with the co-transfer of a plasmid encoding resistance to cadmium. The size of the mupirocin-resistance encoding plasmid in the Nigerian strain (35 IBA) was approximately 35 kb.</p> <p>Conclusion</p> <p>The emergence of mupirocin-resistant <it>S. aureus </it>isolates in Nigeria and South Africa should be of great concern to medical personnel in these countries. It is recommended that methicillin-susceptible <it>S. aureus </it>(MSSA) and MRSA should be routinely tested for mupirocin resistance even in facilities where the agent is not administered. Urgent measures, including judicious use of mupirocin, need to be taken to prevent clonal dissemination of the mupirocin/methicillin resistant <it>S. aureus </it>in KZN, South Africa and the transfer of the conjugative plasmid encoding high-level mupirocin resistance identified in this study.</p