Immunity to heat shock proteins and arthritic disorders.

Adjuvant arthritis (AA) is a frequently used model of experimental arthritis. Because of its histopathology, which is reminiscent of rheumatoid arthritis in humans, AA is used as a model for the development of novel anti-inflammatory drugs. Recently, it has become evident that AA is a typical T-cell-mediated autoimmune condition. Therefore, novel immunotherapies targeted to T cells can be developed in this model. Analysis of responding T cells in AA have now led to the definition of various antigens with potential relevance to arthritis, including human arthritic conditions. One such antigen defined in AA is the 60kD heat shock protein. Both T-cell vaccination approaches and active antigen immunizations and antigen toleration approaches have turned out to be effective in suppressing AA

PROFITABILITY OF GEOGRAPHIC DIVERSIFICATION STRATEGY

Agribusiness,

b anti-b Higgs production at the LHC: Yukawa corrections and the leading Landau singularity

At tree-level Higgs production in association with a b-quark pair proceeds through the small Yukawa bottom coupling in the Standard Model. Even in the limit where this coupling vanishes, electroweak one-loop effects, through the top-Higgs Yukawa coupling in particular, can still trigger this reaction. This contribution is small for Higgs masses around 120GeV but it quickly picks up for higher Higgs masses especially because the one-loop amplitude develops a leading Landau singularity and new thresholds open up. These effects can be viewed as the production of a pair of top quarks which rescatter to give rise to Higgs production through WW fusion. We study the leading Landau singularity in detail. Since this singularity is not integrable when the one-loop amplitude is squared, we regulate the cross section by taking into account the width of the internal top and W particles. This requires that we extend the usual box one-loop function to the case of imaginary masses. We show how this can be implemented analytically in our case. We study in some detail the cross section at the LHC as a function of the Higgs mass and show how some distributions can be drastically affected compared to the tree-level result.Comment: 48 pages, 20 figures. Phys.Rev.D accepted version. Conclusions unchanged, minor changes and references adde

Unified Chew-Mandelstam SAID analysis of pion photoproduction data

A unified description of single-pion photoproduction data, together with pion- and eta-hadroproduction data, has been achieved in a Chew-Mandelstam parametrization which is consistent with unitarity at the two-body level. Energy-dependent and single-energy partial wave analyses of pion photoproduction data have been performed and compared to previous SAID fits and multipoles from the Mainz and Bonn-Gatchina groups.Comment: 11 pages, 9 figures, and 2 table

Rapid Divergence of Wing Volatile Profiles Between Subspecies of the Butterfly Pieris rapae (Lepidoptera: Pieridae)

Complex signaling traits such as pheromone profiles can play an important role in the early stages of reproductive isolation between populations. These signals can diverge along multiple trait axes, and signal receivers are often sensitive to subtle differences in signal properties. In the Lepidoptera, prior research has highlighted that natural selection can drive rapid chemical signal divergence, for instance via mate recognition to maintain species boundaries. Much less is known about the occurrence of such changes for predominantly sexually selected chemical signals, such as those released by many male lepidopterans. We evaluated the divergence in male and female wing volatile profiles between two recently isolated subspecies of the pierid butterfly Pieris rapae Linnaeus (Lepidoptera: Pieridae): P. rapae rapae and P. rapae crucivora. In laboratory settings, these subspecies exhibit strong premating isolation, with females rejecting males of the opposite subspecies despite the fact that males direct equivalent courtship effort toward females of either subspecies. Using gas chromatography–mass spectrometry, we analyzed the volatile chemical profiles of individual males and females of each subspecies. We find that males of each subspecies differ in their wing volatile profiles, including quantitative differences in a male sex pheromone, ferrulactone. In contrast, female wing volatiles profiles have diverged significantly less. These sexspecific patterns suggest that male chemical profiles may play a role in the observed premating isolation between these two subspecies, providing support for future investigations of sexually selected chemical traits in population divergence

The Arboricity Captures the Complexity of Sampling Edges

In this paper, we revisit the problem of sampling edges in an unknown graph $G = (V, E)$ from a distribution that is (pointwise) almost uniform over $E$. We consider the case where there is some a priori upper bound on the arboriciy of $G$. Given query access to a graph $G$ over $n$ vertices and of average degree $d$ and arboricity at most $\alpha$, we design an algorithm that performs $O\!\left(\frac{\alpha}{d} \cdot \frac{\log^3 n}{\varepsilon}\right)$ queries in expectation and returns an edge in the graph such that every edge $e \in E$ is sampled with probability $(1 \pm \varepsilon)/m$. The algorithm performs two types of queries: degree queries and neighbor queries. We show that the upper bound is tight (up to poly-logarithmic factors and the dependence in $\varepsilon$), as $\Omega\!\left(\frac{\alpha}{d} \right)$ queries are necessary for the easier task of sampling edges from any distribution over $E$ that is close to uniform in total variational distance. We also prove that even if $G$ is a tree (i.e., $\alpha = 1$ so that $\frac{\alpha}{d}=\Theta(1)$), $\Omega\left(\frac{\log n}{\log\log n}\right)$ queries are necessary to sample an edge from any distribution that is pointwise close to uniform, thus establishing that a $\mathrm{poly}(\log n)$ factor is necessary for constant $\alpha$. Finally we show how our algorithm can be applied to obtain a new result on approximately counting subgraphs, based on the recent work of Assadi, Kapralov, and Khanna (ITCS, 2019)

Dementia : towards a perceptual control theory perspective

Purpose: The purpose of this paper is to explore the psychosocial experiences of people living with dementia using a perceptual control theory (PCT) perspective. Design/methodology/approach:Conceptual paper. Findings: The paper suggests that people with dementia may control their perceptions by using four modes of control: control, automatic, passive observation and imagination. Research limitations/implications: The paper highlights how a perceived sense of “too little” or “too much” control can create psychological and emotional distress, as people with dementia seek to respond to the changing contextual circumstances of their lives. However, more work needs to be done to develop specific PCT informed strategies that may serve the goal of helping people who are living with dementia to maximise their functioning and alleviate their distress. Originality/value: The potential benefits of adopting a PCT perspective to understand the experiences of people living with dementia have only been explored in a relatively superficial way. This paper is a first attempt to develop a more considered analysis

Selectivity of Wohl-Ziegler Brominations of Cyclohexene and trans-2-Hexene

https://openriver.winona.edu/urc2018/1131/thumbnail.jp

Processing and Composition Effects on the Fracture Behavior of Spray-Formed 7XXX Series Al Alloys

The fracture properties of high-strength spray-formed Al alloys were investigated, with consideration of the effects of elemental additions such as zinc,manganese, and chromium and the influence of the addition of SiC particulate. Fracture resistance values between 13.6 and 25.6 MPa (m)1/2 were obtained for the monolithic alloys in the T6 and T7 conditions, respectively. The alloys with SiC particulate compared well and achieved fracture resistance values between 18.7 and 25.6 MPa (m)1/2. The spray-formed materials exhibited a loss in fracture resistance (KI) compared to ingot metallurgy 7075 alloys but had an improvedperformance compared to high-solute powder metallurgy alloys of similar composition. Characterization of the fracture surfaces indicated a predominantly intergranular decohesion, possibly facilitated by the presence of incoherent particles at the grain boundary regions and by the large strength differentialbetween the matrix and precipitate zone. It is believed that at the slip band-grain boundary intersection, particularly in the presence of large dispersoids and/or inclusions, microvoid nucleation would be significantly enhanced. Differences in fracture surfaces between the alloys in the T6 and T7 condition were observed and are attributed to inhomogeneous slip distribution, which results in strain localization at grain boundaries. The best overall combination of fracture resistance properties were obtained for alloys with minimum amounts of chromium and manganese additions

Ultraviolet relaxation dynamics in uracil: Time-resolved photoion yield studies using a laser-based thermal desorption source

Wavelength-dependent measurements of the RNA base uracil, undertaken with nanosecond ultraviolet laser pulses, have previously identified a fragment at m/z = 84 (corresponding to the C3H4N2O+ ion) at excitation wavelengths ≤232 nm. This has been interpreted as a possible signature of a theoretically predicted ultrafast ring-opening occurring on a neutral excited state potential energy surface. To further investigate the dynamics of this mechanism, and also the non-adiabatic dynamics operating more generally in uracil, we have used a newly built ultra-high vacuum spectrometer incorporating a laser-based thermal desorption source to perform time-resolved ion-yield measurements at pump wavelengths of 267 nm, 220 nm, and 200 nm. We also report complementary data obtained for the related species 2-thiouracil following 267 nm excitation. Where direct comparisons can be made (267 nm), our findings are in good agreement with the previously reported measurements conducted on these systems using cold molecular beams, demonstrating that the role of initial internal energy on the excited state dynamics is negligible. Our 220 nm and 200 nm data also represent the first reported ultrafast study of uracil at pump wavelengths 3(1ππ*) state. These measurements do not, however, provide any evidence for the appearance of the m/z = 84 fragment within the first few hundred picoseconds following excitation. This key finding indicates that the detection of this specific species in previous nanosecond work is not directly related to an ultrafast ring-opening process. An alternative excited state process, operating on a more extended time scale, remains an open possibility