785 research outputs found

    Plurilingual treaties: aspects of interpretation

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    The chapter explores the historical background to plurilingual treaty-making as well as the practice of the PCIJ and ICJ to the interpretation of plurilingual treaties. The chapter includes a detailed examination of Article 33 of the Vienna Convention of the Law of Treaties and the effect of this article on ICJ practice

    Palestinian statehood: trapped between rhetoric and realpolitik

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    This article considers the legal implications of the Palestinian application for full membership of the United Nations (UN)on 23 September 2011 as well as the Palestinian application for UNESCO membership in October 2011 with particular emphasis on whether the entity under the control of the Palestinian Authority (PA) satisfies the criteria of statehood and whether the Palestinian application for membership of the United Nations and UNESCO was in accordance with its obligations under the 1993 Declaration of Principles on Interim Self-Government Arrangements (‘DOP’) and the 1995 Israeli-Palestinian Interim Agreement on the West Bank and the Gaza Strip (‘Interim Agreement’).. The article also makes reference to the Palestinian attempt to recognise the jurisdiction of the International Criminal Court (ICC) in January 2009

    The role of the Rome Statute in the criminalization of Apartheid

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    The article challenges the assertion that the apartheid system in South Africa was a crime under customary international law giving rise to individual responsibility prior to the drafting of the 1998 Rome Statute of the International Criminal Court. The article also examines the role of the Rome Statute in the criminalisation of apartheid and assesses the current status of the crime of apartheid in customary international law with particular reference to the principle of legality (nullum crimen, nulla poena sine lege). Nothing in this article should be read as condoning the gross violations of human rights that resulted from the policies of apartheid in South Africa in any way

    Communism

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    https://stars.library.ucf.edu/prism/1678/thumbnail.jp

    The Impact of Organochlorine Pesticides and Lipid Biomarkers on Type 2 Diabetes Mellitus

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    Type 2 diabetes mellitus (T2DM) is classified as a metabolic disorder characterized by hyperglycemia that results from defects in insulin action and/or secretion, and currently affects 8.3% of the US population according to the CDC’s 2011 National Diabetes Fact Sheet. Several contributing factors have been identified to development of this disease. Published evidence indicates type 2 diabetes mellitus (T2DM) patients display lower overall paraoxonase activity and that this may be partially due to genetic variations in the paraoxonase-1 (PON-1) gene. Some bioaccumulative organochlorine (OC) pesticides have been shown to contribute to increased T2DM prevalence. In addition, these OC compound levels have been associated with alterations in adipocyte cytokine levels as well as increased inflammatory markers. Three hundred blood samples with clinical and demographic information were obtained from two US Air Force hospitals. A total of 151 non-diabetics and 149 T2DM subjects were evaluated for PON-1 activity, PON-1 Q192R and L55M genetic polymorphisms, OC compound concentrations, inflammatory marker levels and adipokine concentrations. PON-1 activity, using diazoxon as the substrate, was decreased in the T2DM subjects. Some of the PON-1 genetic polymorphisms tested were also associated with decreased PON-1 activity. OC compound levels were increased in the T2DM subjects. The non-diabetic subjects possessing elevated DDE and trans-nonachlor were associated with increased inflammation, a common hallmark of early T2DM development. Additionally, elevated OC levels were seen in association with altered adipokine concentrations. Overall, a decrease in the antioxidant properties of PON-1 as well as factors contributing to chronic low level inflammation such as elevated OC plasma concentration appear to be significant contributors to T2DM prevalence in the population studied

    The Impact of Organochlorine Pesticides and Lipid Biomarkers on Type 2 Diabetes Mellitus

    Get PDF
    Type 2 diabetes mellitus (T2DM) is classified as a metabolic disorder characterized by hyperglycemia that results from defects in insulin action and/or secretion, and currently affects 8.3% of the US population according to the CDC’s 2011 National Diabetes Fact Sheet. Several contributing factors have been identified to development of this disease. Published evidence indicates type 2 diabetes mellitus (T2DM) patients display lower overall paraoxonase activity and that this may be partially due to genetic variations in the paraoxonase-1 (PON-1) gene. Some bioaccumulative organochlorine (OC) pesticides have been shown to contribute to increased T2DM prevalence. In addition, these OC compound levels have been associated with alterations in adipocyte cytokine levels as well as increased inflammatory markers. Three hundred blood samples with clinical and demographic information were obtained from two US Air Force hospitals. A total of 151 non-diabetics and 149 T2DM subjects were evaluated for PON-1 activity, PON-1 Q192R and L55M genetic polymorphisms, OC compound concentrations, inflammatory marker levels and adipokine concentrations. PON-1 activity, using diazoxon as the substrate, was decreased in the T2DM subjects. Some of the PON-1 genetic polymorphisms tested were also associated with decreased PON-1 activity. OC compound levels were increased in the T2DM subjects. The non-diabetic subjects possessing elevated DDE and trans-nonachlor were associated with increased inflammation, a common hallmark of early T2DM development. Additionally, elevated OC levels were seen in association with altered adipokine concentrations. Overall, a decrease in the antioxidant properties of PON-1 as well as factors contributing to chronic low level inflammation such as elevated OC plasma concentration appear to be significant contributors to T2DM prevalence in the population studied

    Local integrands for the five-point amplitude in planar N=4 SYM up to five loops

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    Integrands for colour ordered scattering amplitudes in planar N=4 SYM are dual to those of correlation functions of the energy-momentum multiplet of the theory. The construction can relate amplitudes with different numbers of legs. By graph theory methods the integrand of the four-point function of energy-momentum multiplets has been constructed up to six loops in previous work. In this article we extend this analysis to seven loops and use it to construct the full integrand of the five-point amplitude up to five loops, and in the parity even sector to six loops. All results, both parity even and parity odd, are obtained in a concise local form in dual momentum space and can be displayed efficiently through graphs. We have verified agreement with other local formulae both in terms of supertwistors and scalar momentum integrals as well as BCJ forms where those exist in the literature, i.e. up to three loops. Finally we note that the four-point correlation function can be extracted directly from the four-point amplitude and so this uncovers a direct link from four- to five-point amplitudes.Comment: 29 pages LaTeX, 8 figure

    Stratigraphy and chronology of the Stent tephra, a c. 4000 year old distal silicic tephra from Taupo Volcanic Centre, New Zealand.

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    Tephrostratigraphic and chronologic studies in two areas of the North Island have identified a previously unrecorded, thin, distal silicic tephra derived from the Taupo Volcanic Centre. In Taranaki, three radiocarbon ages of the uncorrelated tephra are consistent with the independent radiocarbon chronology obtained from enveloping Egmontsourced tephras. In western Bay of Plenty, where the uncorrelated tephra is also directly dated, it is overlain by Whakaipo Tephra (c. 2.7 ka) and underlain by Hinemaiaia Tephra (c. 4.5 ka). From these sites in Taranaki and western Bay of Plenty, seven radiocarbon dates obtained on the uncorrelated silicic tephra yield an error-weighted mean age of 3970 ±31 conventional radiocarbon years B.P. The ages on the uncorrelated tephra (informally referred to as Stent tephra) from both areas are statistically identical but significantly different from those on both Waimihia and Hinemaiaia Tephras. occurrence of Stent tephra in Taranaki, c. 160 km upwind from the postulated source area, and in western Bay of Plenty, suggests that it represents the product of a moderately large plinian eruption. Until recently, its validity as a discrete eruptive event had been problematical, because a near-source equivalent deposit between Waimihia and Hinemaiaia Tephras was not recognised in the Taupo area. However, a revised stratigraphy proposed by C. J. N. Wilson in 1993 for eastern sectors of the Taupo area shows that multiple tephra layers were erupted from Taupo volcano between c. 3.9 and 5.2 ka. Of these newly recognised layers, unit-g--the product of a moderately large eruption (>0.15 km3) at c. 4.0 ka--is tentatively correlated with Stent tephra. Other eruptive units recognised by Wilson are either too old or too small in volume to be considered as likely correlatives

    HEAVY-TAILED DISTRIBUTIONS AND THE CANADIAN STOCK MARKET RETURNS

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    Many of financial engineering theories are based on so-called “complete markets” and on the use of the Black-Scholes formula. The formula relies on the assumption that asset prices follow a log-normal distribution, or in other words, the daily fluctuations in prices viewed as percentage changes follow a Gaussian distribution. On the contrary, studies of actual asset prices show that they do not follow a log-normal distribution. In this paper, we investigate several widely-used heavy-tailed distributions. Our results indicate that the Skewed t distribution has the best empirical performance in fitting the Canadian stock market returns. We claim the results are valuable for market participants and the financial industry

    Co-operative preservation activities in the UK: findings of a research project

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    Reports the findings of a BLRIC-funded research project, which set out to identify and evaluate current and recent co-operative preservation activities, and produce guidelines which will help librarians and archivists to engage in successful co-operative preservation activity
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