Implications for degenerative disorders: Antioxidative activity, total phenols, flavonoids, ascorbic acid, β-carotene and β-tocopherol in Aloe vera

In order to demonstrate whether the known biological effects of Aloe vera (L.) Burm. fil. could correlate with the antioxidant activity of the plant, the antioxidant activity of the aqueous leaf extract was investigated. The present study demonstrated that the aqueous extract from A. vera leaves contained naturally occuring antioxidant components, including total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol. The extract exhibited inhibitory capacity against Fe3+/ascorbic acid induced phosphatidylcholine liposome oxidation, scavenged stable DPPH•, ABTS•+ and superoxide anion radicals, and acted as reductant. In contrast, the leaf inner gel did not show any antioxidant activity. It was concluded that the known beneficial effects of Aloe vera could be attributed to its antioxidant activity and could be related to the presence of phenolic compounds and antioxidant vitamins

Implications for degenerative disorders Antioxidative activity, total phenols, flavonoids, ascorbic acid, beta-carotene and alpha-tocopherol in Aloe vera

In order to demonstrate whether the known biological effects of Aloe vera (L.) Burm. fil. could correlate with the antioxidant activity of the plant, the antioxidant activity of the aqueous leaf extract was investigated. The present study demonstrated that the aqueous extract from A. vera leaves contained naturally occuring antioxidant components, including total phenols, flavonoids, ascorbic acid, beta-carotene and alpha-tocopherol. The extract exhibited inhibitory capacity against Fe3+/ascorbic acid induced phosphatidylcholine liposome oxidation, scavenged stable DPPH center dot, ABTS(center dot+) and superoxide anion radicals, and acted as reductant. In contrast, the leaf inner gel did not show any antioxidant activity. It was concluded that the known beneficial effects of Aloe vera could be attributed to its antioxidant activity and could be related to the presence of phenolic compounds and antioxidant vitamins

Implications for Degenerative Disorders: Antioxidative Activity, Total Phenols, Flavonoids, Ascorbic Acid, β-Carotene and β-Tocopherol in Aloe vera

In order to demonstrate whether the known biological effects of Aloe vera (L.) Burm. fil. could correlate with the antioxidant activity of the plant, the antioxidant activity of the aqueous leaf extract was investigated. The present study demonstrated that the aqueous extract from A. vera leaves contained naturally occuring antioxidant components, including total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol. The extract exhibited inhibitory capacity against Fe3+/ascorbic acid induced phosphatidylcholine liposome oxidation, scavenged stable DPPH•, ABTS•+ and superoxide anion radicals, and acted as reductant. In contrast, the leaf inner gel did not show any antioxidant activity. It was concluded that the known beneficial effects of Aloe vera could be attributed to its antioxidant activity and could be related to the presence of phenolic compounds and antioxidant vitamins

Investigation of aloe-emodin and Aloe vera gel extract on apoptosis dependent pathways in leukemia and lymphoma cell lines

Background and Aims: The present study was designed to evaluate the mechanism of cytotoxic effects of aloe-emodin relative to Aloe vera gel extract (AVG) on chronic myelogenous leukemia K562 and Burkitt's lymphoma P3HR-1 cell lines

Evaluation of the anticancer effects of Aloe vera and aloe emodin on B16F10 murine melanoma and NIH3T3 mouse embryogenic fibroblast cells

Aloe vera (L.) Burm. f. is well known for its beneficial effects on the skin. Moreover, the antioxidant, immunostimulant, and anticancer effects of the plant leaf extracts have been reported in scientific research. This study was conducted to demonstrate the cytotoxic effects of several leaf extracts and aloe emodin (AE) on a type of skin cancer. A. vera aqueous and methanolic extracts of fresh leaves, methanolic extract of dried leaves, and leaf gel extract (AVG) were prepared separately. Cytotoxicity was assessed using the MTT test. Apoptosis and necrosis were detected by flow cytometry using Annexin V/PI. All the extracts exhibited a selective cytotoxic effect on the cells. The mechanism of AVG cytotoxicity on B16F10 murine melanoma cells was found to be apoptosis, whereas that of AE was necrosis. The observation that treatment with AVG delayed the apoptosis in NIH3T3 cells, while it exerted an apoptotic activity on B16F10 cells, provides some scientific evidence for the folkloric and alternative uses of A. vera gel as a protective and skin healer. Therefore, A. vera gel and aloe emodin can be used as potential targets for anticancer drug research

Cytotoxic Effects of Some Flavonoids and Imatinib on the K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method

Background: Flavonoids are natural compounds with antioxidant, anticarcinogenic, and anti-inflammatory effects

Twenty years of research on Aloe vera

Aloe vera, sometimes referred as a "miraculous" or "wonder" plant, has been used by mankind for centuries for the treatment of different disorders due to the inner gel of its succulent leaves. Medical usage and applications of the main species, namely Aloe vera (L.) Burm. f. are mainly attributed to immunomodulatory or antioxidant activities