16 research outputs found
Acute Promyelocytic Leukemia: an Experience on 95 Greek Patients Treated in the All-Trans-Retinoic Acid Era
Acute promyelocytic leukemia (APL) is highly curable with the combination of all-transretinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypic, cytogenetic and molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus
Expression analysis of proteins involved in the non homologous end joining DNA repair mechanism, in the bone marrow of adult de novo myelodysplastic syndromes
Extrahepatic right portal vein ligation allows parenchyma-sparing en bloc resection of segments 7,8 and 4a for liver tumors engaging the right and middle hepatic veins
Right trisectionectomy for posterior liver tumors engaging the right and
middle hepatic veins may lead to post-hepatectomy liver failure if the
anticipated liver remnant is small. In such patients we developed a
parenchyma-sparing one-step approach, that includes extrahepatic right
portal vein ligation accompanied by en bloc resection only of segments
7, 8 and 4a and resection of the right and middle hepatic veins. The
technique was applied in 3 patients with normal liver function, where
according to the preoperative computed tomography the volume of segments
1, 2 and 3 ranged between 17% and 20% of the total liver volume. In
all patients liver biochemistry improved rapidly postoperatively and a
doubling of volume of segments 1,2 and 3 was achieved by the third
postoperative week, as extrahepatic right portal vein ligation
ameliorated reperfusion injury of the remaining segments 5 and 6 and
induced hypertrophy of segments 1, 2, 3 and 4b. There was no mortality
or long-term complications. Patients are alive and free of disease 74,
50 and 17 months after the operation, respectively. We propose that the
term “extended upper right sectionectomy” may be considered for the
en bloc resection of segments 7,8 and 4a, in future revisions of the
Brisbane 2000 terminology of hepatic anatomy and resections
LARGE ADRENAL ONCOCYTOMA WITH UNCERTAIN MALIGNANT POTENTIAL: CASE REPORT AND REVIEW OF LITERATURE
Objective: To report a case of oncocytoma; a relatively rare adrenal
tumor, which most commonly is detected as an adrenal incidentaloma.
Methods: We present a case report, including laboratory, imaging, and
pathologic findings, of a 47-year-old obese woman who had hypertension
and an incidentally found large, left adrenal mass.
Results: On the basis of the hormonal evaluation, this mass was a
nonsecreting adrenal tumor, which histologically proved to be an
oncocytoma with borderline malignant characteristics. A collective
analysis of the few cases of adrenal oncocytoma published in the medical
literature showed that our case corresponded to the previously published
cases in preponderant location (left side) as well as the general size
(11.4 cm in the largest dimension) and weight (372 g).
Conclusion: Adrenal oncocytoma should be included in the differential
diagnosis of adrenal incidentalomas, especially if large tumors are
detected. In addition, a long-term follow-up is suggested because there
are no certain clues about the true potential of this tumor. (Endocr
Pract. 2010;16:641-645
A novel germline mutation of the VHL gene in a Greek family with Von Hippel–Lindau disease
Von Hippel–Lindau disease (VHL) is an autosomal dominant disorder, caused by mutations of the VHL gene showing a strong genotype–phenotype correlation. The present report concerns a 16-year-old girl with VHL (retinal, spinal cord and cerebellar haemangioblastomas and pancreatic cysts), her father (retinal and spinal cord haemangioblastomas) and the phenotypically healthy mother and younger brother and sister. DNA extraction, PCR and direct sequencing of the VHL entire coding and intronic flanking sequences, were performed according to standard procedures. In the index patient and her father a novel heterozygous germline was identified; nonsense mutation (p.145X) in exon 2 of VHL, leading to a truncated VHL protein lacking the last 66 amino acids. This is the first report of a novel VHL mutation in patients with VHL associated with haemangioblastomas and pancreatic cysts but not renal cell carcinoma