The reality of design process planning

Most companies struggle with the efficiency of their processes. One contributory factor is the lack of efficient process planning. This paper describes current planning practise in industry, which uses a multitude of different plans in parallel. The units of planning and their resulting plans roughly fall into product plans considering cost, bill of material and procurement considerations; process plans including different milestone, task and activity plans and quality plans. This paper maps out the ownership of these plans, and establishes that organisations work because individuals use more then one plan and have a tacit understanding of the relationships between these plans. The lack of effective plans affects the company through a lack of understanding of process connectivity and in consequence bad communication

Model granularity and related concepts

Models are integral to engineering design and basis for many decisions. Therefore, it is necessary to comprehend how a model’s properties might influence its behaviour. Model granularity is an important property but has so far only received limited attention. The terminology used to describe granularity and related phenomena varies and pertinent concepts are distributed across communities. This article positions granularity in the theoretical background of models, collects formal definitions for relevant terms from a range of communities and discusses the implications for engineering design

Towards a change process planning tool

The relationship between a product and its design process is generally complex and not fully understood. When modifying a product, industry still rarely considers the implementation process and its consequences for other design activities in the company, which is hard to assess with conventional planning methods. Although change processes are highly constrained, product and process constraints are not usually considered together or traded off against each other when planning the change. Inadequate assessment and planning of the change implementation process can lead to costly knock-on effects across the product and the design process. This paper argues for a combination of change and process research and discusses requirements for a change process planning tool. It proposes a system for the analysis of the impact of change on the product as well as other company activities. Then, a more informed selection between change alternatives is possible

Echinococcus multilocularis coproantigen detection by enzyme-linked immunosorbent assay in fox, dog, and cat populations

A sandwich enzyme-linked immunosorbent assay (ELISA) for the detection of Echinococcus multilocularis coproantigens (EM-ELISA) was developed with polyclonal rabbit (solid phase) and chicken egg (catching) antibodies that were directed against E. multilocularis coproantigens and somatic worm antigens, respectively. In experimentally infected dogs and cats, coproantigens were first detectable 6-17 days postinfection (PI) in samples of 8 dogs (worm burdens at necropsy: 6,330-43,200) and from 11 days PI onward in samples of 5 cats infected with 20-6,833 worms. After anthelmintic treatment of 4 dogs and 5 cats at day 20 PI, coproantigen excretion disappeared within 3-5 days. The sensitivity of the ELISA was 83.6% in 55 foxes infected with 4-60,000 E. multilocularis, but reached 93.3% in the 45 foxes harboring more than 20 worms. The EM-ELISA was used in surveys of 'normal' dog and cat populations in Switzerland. Among 660 dogs and 263 cats, 5 dogs and 2 cats exhibited a positive reaction. In 2 of these dogs (0.30%) and 1 cat (0.38%), intestinal E. multilocularis infections were confirmed by necropsy, polymerase chain reaction PCR, or both. The specificities of the ELISA in these groups were found to be 99.5% and 99.6%, respectively, if positive ELISA results that could not be confirmed by other methods were classified as 'false positive' reactions

The spiral of applied research: A methodological view on integrated design research

Abstract not available

Parameter trails

Successful communication is vital for the success of any design project. However, communication often fails, adversely affecting design process efficiency and product quality.understand the connections between different aspects of design and don–t know where to find out more information or who to talk to. This paper presents a new model, developed from current project planning techniques, which supports communication using parameter-specific data. It enables designers to question information, inform their colleagues pro-actively and assess the impact of changing parameter values on subsequent design tasks. Such interaction is critical in allowing designers to see how their own tasks fit into the overall product design

A functional analysis of change propagation

A thorough understanding of change propagation is fundamental to effective change management during product redesign. A new model of change propagation, as a result of the interaction of form and function is presented and used to develop an analysis method that determines how change is likely to propagate. The analysis produces a Design Structure Matrix, which clearly illustrates change propagation paths and highlights connections that could otherwise be ignored. This provides the user with an in-depth knowledge of product connectivity, which has the potential to support the design process and reduce the product's susceptibility to future change

Environmental legislation as a driver of design

and other research output

An improved test system for PCR-based specific detection of Echinococcus multilocularis eggs

For the sensitive detection of eggs of Echinococcus multilocularis in fox faeces by PCR we have evaluated a method based on the previous concentration of helminth eggs by a combination of sequential sieving of faecal samples and flotation of the eggs in zinc chloride solution. The eggs were microscopically detected in the fractions retained in 40 and 20µm mesh sieves. DNA of the taeniid eggs retained in the 20 µm sieve was obtained after alkaline lysis and PCR was performed using E. multilocularis species-specific primers. Compared to the parasitological findings after examination of the small intestines of the foxes, the specificity of the PCR was 100% (no false-positive result with 20 foxes free of E. multilocularis) and the sensitivity was 94% (33 positive results from total 35 foxes proven to be infected with E. multilocularis). Both false-negative results were obtained with faeces from foxes harbouring immature worms. Using faecal volumes between 2 and 20 ml, no inhibition of PCR was observed as was demonstrated by the amplification of size-modified target in parallel reactions. The tests were undertaken with fresh faeces stored in 70% ethanol, but egg detection by PCR was also possible after inactivation of eggs by freezing the faeces at −80°C for one week or by incubation at +70°C for 2