The effect of probiotic therapy on quality of life and depressive symptoms in patients with diarrhea-predominant irritable bowel syndrome

Aim: The aim of this study was to analyze the effect of probiotics on quality of life and depressive symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS) and moderate or severe depressive mood. Materials and Methods: Patients diagnosed with diarrhea-predominant IBS using the Rome IV criteria and Bristol Stool Form Scale and with moderate or severe depressive symptoms according to the Beck Depression Inventory comprised the study participants. The patients were randomized and divided into two groups as the medication only group and the medication + probiotic group. The IBS 36 questionnaire and Beck’s Depression Inventory were administered to all patients in the first and second groups and the scores were recorded. Results: The change in IBS-36 scores from the beginning to the 10th week was significant in both groups (p<0.001). According to the IBS-36, the median change from the beginning to the 10th week was 32 for the medication group and 48 for the medication + probiotic group. The change in the Beck’s Depression Inventory scores from the beginning to the 10th week was significant in both the medication group and the medication + probiotic group (p<0.001). According to the Beck’s Depression Inventory, the median change from the beginning to the 10th week was 7 for the medication group and 9.5 for the medication + probiotic group. Conclusion: In the treatment of diarrhea-predominant IBS patients, the use of probiotics together with traditional drugs will improve quality of life by reducing both gastrointestinal symptoms and psychological symptoms

Zinc in fibromyalgia patients: relationship with body mass index and sleep quality

Introduction and aim. Given the potential relationship between oxidative stress and fibromyalgia and well-documented antioxidant efficacy of zinc, the present study aimed to determine serum zinc concentration in FM patients as compared to healthy controls, as well as to identify the correlation of serum zinc concentration with the body mass index (BMI) and sleep quality, Material and methods. In this case-control study, 54 fibromyalgia patients were consecutively recruited between October 01, 2021 and December 01, 2021. The control group consisted of 54 age- and sex-matched healthy controls. Results. Fibromyalgia group had significantly lower zinc concentration, higher body mass index, and lower sleep quality scores as compared to the healthy control group. The correlation analysis revealed a significantly negative correlation between serum zinc concentration and body mass index and a significantly positive correlation between serum zinc concentration and sleep quality both in fibromyalgia and healthy control groups. Conclusion. Our results both support the hypothesis that low serum zinc concentration plays a role in the pathophysiology of fibromyalgia and indicate that fibromyalgia may lead to weight gain and poor sleep quality, which needs to be confirmed in large-cohort studies

Helicobacter pylori eradikasyon tedavisi sonrasi hastatakibinde nöltrofil lenfosit oranının duyarlılık ve özgüllüğü

Objective: The aim of this study is to determine the sensitivity and specificity of the NLR ratio in order to assess treatment effectiveness in the follow-up of patients who are endoscopic H. pylori-positive and administered eradication therapy. Materials and Methods: The Endoscopy Unit at Istanbul Medipol University Pendik Hospital evaluated 386 individuals who underwent upper gastrointestinal endoscopy. Neutrophil and lymphocyte counts, as well as neutrophil-to-lymphocyte ratios (NLR), were compared in HP positive and negative patients. H. pylori eradication was performed on 205 HP-positive patients using a 2-week triple therapy. All patients had a complete blood count done at the same time, and NLR was computed and compared between the eradicated and non-eradicated groups. Results: H. pylori eradication was accomplished in 100 (48.7%) of the patients, whereas the stool antigen test was positive in 105 (51.3%) of the patients. There was a statistically significant difference in neutrophil counts (P<0.0001), lymphocyte counts (P<0.0001), and neutrophil-to-lymphocyte ratio (P<0.0001). The sensitivity and specificity in identifying Helicobacter pylori eradication were determined to be 90.5% and 85%, respectively when the cutoff value for the Neutrophil-to-Lymphocyte ratio was set at 2.058. Conclusion: The neutrophil-to-lymphocyte ratio was shown to be greater in HP (+) cases based on the parameters discovered in the complete blood count in our study. We believe that this measure might be used to monitor patients during and after therapy, but additional research with larger sample sizes is needed to assess changes in neutrophilto-lymphocyte ratio as a follow-up indicator following successful HP eradication therapy.Giriş ve Amaç: Endoskopik olarak H. Pilory pozitifliği tespit edilen ve eradikasyon tedavisi uygulanan hastaların takibinde tedavinin başarısını gözlemlemek için NRL oranının sensitivite ve spesifitesini ortaya koymayı amaçladık. Gereç ve Yöntem: İstanbul Medipol Üniversitesi Pendik Hastanesi, Endoskopi Ünitesi’nde, üst gastrointestinal sistem endoskopisi yapılan 386 hasta değerlendirildi. HP pozitif ve negatif olan hastaların nötrofil, lenfosit sayıları, nötrofil lenfosit oranları (NLO) karşılaştırıldı. HP pozitif olan 205 hastaya 2 haftalık üçlü tedavi ile H. pylori eradikasyonu uygulandı. Tedavi bitiminden 4 hafta sonra gaitada H. Pilori antijen testi yapıldı ve negatif sonuç eradikasyon olarak tanımlandı. Eş zamanlı olarak tüm hastalara tam kan sayımı yapılarak. NLO hesaplandı ve değerler eradike edilen ve edilemeyen gruplar arasında karşılaştırıldı. Bulgular: H. Pilory eradikasyonu 100 (%48,7) hastada sağlanabilmişken 105 (%51,3) hastanın gaitada antijen testi pozitif olarak geldi. Bu iki grup arasında nötrofil sayıları (P<0,0001), lenfosit sayıları(P<0,0001), ile nötrofil lenfosit oranı (P<0,0001) arasında istatistiksel olarak anlamlı fark mevcuttu. Nötrofil /Lenfosit oranının cutoff değeri 2,058 alındığında Helikobakter pilori eradikasyonunu tespit etmedeki duyarlılık ve özgüllüğü sırasıyla %90,5 ve %85 olarak tespit edildi Sonuç: Çalışmamızda, tam kan sayımında bulunan parametrelerden elde edilen nötrofil/lenfosit oranı HP (+) olgularda daha yüksek bulunmuştur. Bu belirtecin tedavi süresince ve tedaviden sonra hastaları takip etmek için yararlı olabileceğini ancak başarılı HP eradikasyonu tedavisinden sonra, takip belirteci olarak nötrofil/ lenfosit oranındaki değişiklikleri değerlendirmek için daha geniş örneklem grubu ile yapılacak daha çok sayıda çalışmaya ihtiyaç olduğunu düşünmekteyiz

Impact of lavender herbal tea on sleep quality in elderly patients with poor sleep quality: A randomized study

Objective: Aromatherapy has been used as a complementary alternative therapy in elderly adults with poor sleep quality. Lavender has sedative, anxiolytic, and analgesic properties. This study aimed to evaluate effect of lavender herbal tea in different doses on sleep quality of elderly people. Material-Method: This study has been designed as a prospective, randomized study with a two-arm parallel design. There were 94 patients aged between 65 and 75 years with a Richards-Campbell Sleep Questionnaire (RCSQ) score of 0.05) or in terms of baseline RCSQ scores (p=0.685). However, 1st-month and 3rd-month RCSQ scores in patients who used 2 g lavender tea bags were significantly higher than those who used 1 g herbal tea bags (p<0.001 and p<0.001, respectively). Additionally, the 1st-month and 3rd-month RCSQ scores were significantly higher than baseline RCSQ scores in both groups (p<0.05). Conclusion: Our findings revealed that lavender herbal tea improved sleep quality in elderly patients with sleep problems. Consumption of higher doses of lavender tea (2 g vs. 1 g) resulted in significantly higher RCSQ scores. Therefore, use of lavender may be recommended in individuals with sleep problems in form of herbal tea preparations

The effect of weight loss on serum ceruloplasmin levels in obese patients

Introduction and aim. Serum ceruloplasmin level may be a biomarker associated with obesity and cardiovascular risk. We aimed to evaluate the effect of body weight lost by diet and exercise program on metabolic parameters and serum ceruloplasmin levels in obese patients. Material and methods. A total of 120 obese patients with BMI ≥30 kg/m2 were enrolled in a 16-week balanced diet program with the goal of losing 10% or more of body weight while maintaining a daily energy deficit of 500-1000 kcal/day. Results. Mean weights of the patients decreased from 93.2±15.1 kg to 83.2±13.1 kg (p<0.001) and mean BMI decreased from 35.8±5.6 kg/m2 to 31.9±4.9 kg/m2 (p<0.001). Mean ceruloplasmin decreased from 25.2±4.7 mg/dL to 23.6±4.9 mg/dL (p<0.001), mean total cholesterol from 191.8±37.1 mg/dL to 153.8±28.7 mg/dL (p<0.001), mean LDL from 120.3±31.4 mg/dL to 91.1±27.7 mg/dL (p<0.001) and mean fasting blood glucose from 108.2±35 mg/dL to 103.3±81.1 mg/dL (p[removed

Impact of capsella bursa-pastoris (Shepherd’s Purse) herbal tea preparations on symptoms and severity of hemorrhoidal disease: A prospective randomized study

Objectives: Medicinal herbs have been used to treat hemorrhoidal disease for centuries. Given its anti-oxidant and anti-inflammatory mechanisms, Capsella bursa-pastoris (Shepherd’s purse) may potentially lead to regression of the hemorrhoidal plexuses. In this context, the objective of this study is to investigate the effect of Capsella bursa-pastoris, an affordable and easy-to-use herbal medicine, on the severity and physical examination findings of hemorrhoidal disease in patients, who receive conventional treatment for hemorrhoids. Material-Method: This study was designed as a prospective, randomized study. The population of the study comprised symptomatic patients who presented with second and third-degree hemorrhoids to the Internal Medicine and General Surgery departments of Istanbul Medipol University Hospital, İstanbul, Turkey, between October 2021 and February 2022. The patients were randomized into two groups: the control group, that is, the group of patients, who were to receive conservative treatment only for three months, and the study group, that is, the group of patients who were to receive conservative treatment and use herbal tea preparations of Capsella bursa-pastoris for three months. Demographic (age and gender) and baseline and 3-month clinical characteristics were recorded. The study's primary outcome was the changes observed in the symptoms and physical examination findings of hemorrhoidal disease in the study group relative to those in the control group. Results: The study sample consisted of a total of 218 patients, who were randomized into the study and control groups, with 109 patients in each group. Significantly older patients were seen in Group CT (39.5 ± 14.6 and 35.5 ± 11.7 years, p=0.030). There was no significant difference between the groups in terms of other characteristics (p>0.05). At the 3rd-month follow-up examination, it was determined that there were significantly fewer patients with bleeding and difficulty during defecation in the study group compared to the control group (p=0.001 for both cases). Patients in the study group had significantly lower VAS scores for pain and the number of affected quadrants compared to those in the control group (p<0.001 for both cases). The proportion of patients with Grade II and III hemorrhoidal disease was significantly lower in the study group. Conclusion: The findings of this study, which revealed significant improvements in the symptoms and physical examination findings of hemorrhoidal disease, suggest that the use of Capsella bursa-pastoris herbal tea may benefit patients with symptomatic hemorrhoids

Tip 2 diabetes mellitus tanılı hastalarda ortostatik hipotansiyon ile D vitamini eksikliği arasındaki ilişki

Objective: Vitamin D deficiency is common in diabetic patients, and studies showed that it could lead to neuropathy. Therefore, we aimed to determine relationship between 25-hydroxyvitamin D (25(OH)D) levels and orthostatic hypotension (OH) which is a component of autonomic neuropathy in diabetic patients.Materials and Methods: A total of 118 patients with Type 2 diabetes mellitus and aged 50-65 years were included. Patients were divided into two groups as OH present and OH not present. 25(OH)D and other variable parameters were evaluated between these two groups.Results: A total of 118 patients, 66 female and 52 male, were included in this cross-sectional study. The mean age of the patients was 56.2±3.2 years.25(OH)D levels were found to be significantly lower in the group with OH (p0.05).Conclusion: 25(OH)D levels are significantly lower in diabetic patients with OH. Although an independent relationship between them has not been demonstrated, it can be thought that correcting Vitamin D deficiency will be beneficial in the treatment of OH.Amaç: D vitamini eksikliği diyabetik hastalarda sık görül-mekte ve çalışmalarda nöropatiye yol açabileceği gösteril-miştir. Bu çalışmada diyabetik hastalarda otonom nöropatinin bir bileşeni olan ortostatik hipotansiyon (OH) ile 25-hidroksivitamin D (25(OH)D) seviyesi arasındaki ilişkiyi belirlemeyi amaçladık. Materyal ve Metot: Çalışmaya 50-65 yaş arası diyabetik toplam 118 hasta dahil edildi. Hastalar OH varlığına göre iki gruba ayrıldı. 25(OH)D ve diğer değişken parametreler bu iki grup arasında değerlendirildi. Bulgular: Bu kesitsel çalışmaya 66 kadın ve 52 erkek olmak üzere toplam 118 hasta dahil edildi. Hastaların yaş ortalaması 56,2±3,2 yıl idi. 25(OH)D düzeyleri OH olan grupta anlamlı olarak daha düşük bulundu (p 0,05). Sonuç: OH'li diyabetik hastalarda 25(OH)D düzeyleri anlamlı olarak daha düşüktür. Aralarında bağımsız bir ilişki gösterilemese de OH tedavisinde D vitamini eksikli-ğinin düzeltilmesinin faydalı olacağı düşünülebilir

The cornerstone of sustainability: ecological footprint

İnsan nüfusunun artması ve teknolojinin gelişmesiyle birlikte doğal kaynaklara olan talep her geçen gün artmaktadır. Üretim ve tüketim ihtiyaçlarını sağlamak için kullanılan doğal kaynaklar insanların dünyanın sahibi olduğuna dair düşüncelerinden dolayı tahrip edilerek düşüncesizce kullanılmaktadır. Ekolojik ayak izi ifadesi kaynak kullanımının sürdürülebilir bir biçimde gerçekleştirilebilmesi için kullanılan sayısal bir metottur. Bu metot ekolojik kaynakların ekonomik değerlerinin olduğunu belirten ekolojik ekonomi ve sürdürülebilirlik kavramlarının bir bütününü temsil etmektedir. Ekolojik ayak izi kavramı, tüketilen ekolojik verimli kaynak miktarlarını ve bu kaynakların alan bazında belirlenmesini sağlayarak ekolojik kaynak tüketimini sayısallaştırmaktadır. Son zamanlarda sürdürülebilirlik kavramının disiplinler arası değerlendirilmesi sonucunda ekolojik ayak izi kavramı genişletilerek ayak izi ailesi kavramı oluşturulmuştur. Ayak izi ailesi, ekolojik kaynakların tüketiminin kaynak bazında değerlendirilmesini sağlayarak her bir kaynağın sürdürülebilirliğini sağlamaktadır. Bu çalışmada, ekolojik kaynakların sürdürülebilir yönetiminde anahtar rol oynayan ekolojik ayak izi kavramının tarihçesi ve kaynakların yönetiminde etkin olan ayak izi ailesi hakkında detaylı bir derleme çalışması yapılmıştır.With the increase of human population and the development of technology, the demand for Natural Resources is increasing day by day. The natural resources used to supply the needs of production and consumption are destroyed and used thoughtlessly because of people's belief that they own the world. The term of ecological footprint is a numerical method used for sustainable usage of resources. Ecological footprint expression is a numerical method for sustainable use of resources. This method represents whole of the concepts of ecological economy and sustainability which that present ecological resources have economic value. This method represents a whole of the concepts of Ecological Economics and sustainability, which indicate that ecological resources have economic values. The concept of ecological footprint digitizes ecological resource consumption by ensuring that the amounts of ecologically efficient resources consumed and those resources are determined on a field basis. Recently, as a result of the interdisciplinary evaluation of the concept of sustainability, the concept of ecological footprint has been expanded and the concept of footprint family has been created. The footprint family provides the sustainability of each resource by ensuring that the consumption of ecological resources is assessed on a resource-by-resource basis. In this study, a detailed review of the history of the ecological footprint concept, which plays a key role in the sustainable management of ecological resources, and the footprint family that is effective in the management of resources, has been conducted

Effects of oral selenium replacement on TSH in patients with subclinic hipotiroidism with low serum selenium levels

AMAÇ: Selenyum insan vücudunun önemli metabolik yolaklarının vazgeçilmez bir bileşenidir. Aktif bölgesine selenosistein şeklinde selenyum katılmış proteinler, selenoproteinler olarak tanımlanmaktadır ve bu proteinlerin fonksiyonlarını yerine getirmeleri için selenyuma gereksinimleri vardır. Selenyum elementi, Glutatyonperoksidaz (GPXs), Tioredoksinredüktaz (TRs) ve iyodotironindeiyodinaz (İD) gibi selenoproteinlerin yapısında bulunmaktadır. Selenoproteinler, tiroid hormon biyosentezine ve metabolizmasına, antioksidan savunma sisteminin kontrolüne katkı sağlamaktadır. Çalışmamızda subklinik hipotiroidisi olan otoimmün tiroidit hastalarına selenyum düşüklüğünün ne sıklıkla eşlik ettiğini ve selenyumu düşük olan hastalarda oral selenyum replasmanının tiroit stimülan hormon (TSH) üzerine etkilerini ortaya koymayı hedefledik.GEREÇ VE YÖNTEM: Çalışmamızda Aralık 2019 ile Temmuz 2020 aralığında 18 yaşından büyük olup polikliniğimize başvurmuş olan, asemptomatik subklinik hipotiroidisi olan 69 hastayı değerlendirdik. Serum selenyum düzeyi 80 μg/L’den düşük olan hastalara 3 ay süre ile yumuşak bir jel kapsül içinde oral yolla günde 83 mcg selenometiyonin verildi. Başka bir tedavi uygulanmadı. Üçüncü ayın sonunda tüm hastalarda serum tiroid hormon profiline ve selenyum seviyelerine bakıldı. Subklinik hipotiroidisi olan otoimmün tiroiditli hastaların, yüzdelik dilimler kullanılarak, oral selenyum replasmanı sonrası TSH seviyelerindeki değişiklikler gözlemlendi.BULGULAR: Çalışmamızda Aralık 2019 ile Temmuz 2020 arasında polikliniğimizde tespit edilen 69 asemptomatik subklinik hipotiroidisi olan hasta değerlendirildi. Çalışma kriterlerine uyumlu 43 hastanın 12 tanesinde (%28) serum selenyum düzeyi normal, 31 (%72) tanesinde serum selenyum düzeyi düşük (<80 μg/L) olarak tespit edildi. Üç ay boyunca günlük 83 mcg selenometiyonin oral selenyum replasman tedavisi verilen hastaların 19 (%61)’unda TSH değerinin normal sınırlar içerisine gerilediği görüldü (0,5mIU/L10.00 mIU/L) tespit edilirken, 9 (%29) hastada ise TSH değerinin halen 4.26 mIU/L- 10.00 mIU/L aralığında olduğu görülerek bu hastlara levotiroksin tedavisi başlandı.SONUÇ: Çalışmamızda selenyum eksikliği bulunan asemptomatik otoimmün subklinik hipotiroidi hastalarına oral selenyum replasmanı yaparak, serum TSH değerleri üzerindeki kısa dönem etkilerini değerlendirdik ve hastaların %61 inin 3 ay içerisinde ötiroid olduğunu gözlemledik. Selenyum eksikliğinin replase edilmesinin, teorik anlamda otoimmün tiroidit başta olmak üzere tüm otoimmün hastalıkların inflamatuar ve oksidatif hasar sürecine olan olumlu etkileri mevcuttur. Ancak bu konuda deneysel ve klinik prospektif planlanmış ve alt grupların detaylandırıldığı kapsamlı çalışmaların yapılması gerektiğini düşünüyoruz.OBJECTIVE: Selenium is an essential component of important metabolic pathways of the human body. Proteins in which selenium is added to the active site in the form of selenocysteine are defined as selenoproteins and they require selenium to fulfill their functions. Glutathioneperoxidase (GPXs) is found in such selenoproteins as Thioredoxinreductase (TRs) and Iodothyroninedeiodinase (ID). Selenoproteins contribute to thyroid hormone biosynthesis and metabolism and the control of the antioxidant defence system. In our study, we aimed to reveal how often patients with subclinical hypothyroidism and autoimmune thyroiditis are accompanied by low serum selenium level and the effects of oral selenium replacement on Tiroit Stimulating Hormone (TSH) in patients with low selenium.MATERIAL AND METHODS: In our study, we evaluated 69 patients who were with asymptomatic subclinical hypothyroidism and aged older than 18 and who applied admitted to our outpatient/out-patient clinic between December 2019 and July 2020. Patients with serum selenium levels lower than 80 μg / L were given 83 mcg of selenomethionine in a soft gel capsule for 3 months. No other treatment was applied. At the end of the third month, serum thyroid hormone profile and selenium levels were measured in all patients. Changes in TSH levels were observed in patients with autoimmune thyroiditis with subclinical hypothyroidism after oral selenium replacement by using percentiles.RESULTS: In our study, 69 patients with asymptomatic subclinical hypothyroidism diagnosed in our outpatient clinic between December 2019 and July 2020 were evaluated. Serum selenium level was identified as normal in 12 (28%) of 43 patients, and serum selenium level was identified as low (<80 μg / L) in 31 (72%) patients. TSH values were found as regressed within normal limits (0,5mIU/L 10.00 mIU / L) in 3 (10%) patients, the TSH value was identified as still in the range of 4.26 mIU / L-10.00 mIU / L in 9 (29%) patients and levothyroxine treatment was started in these patients.CONCLUSIONS: In our study, we evaluated the short-term effects of oral selenium replacement in asymptomatic autoimmune subclinical hypothyroid patients with selenium deficiency, on serum TSH values and we observed that 61% of patients were euthyroid within 3 months. Replacing selenium deficiency has positive effects on the inflammatory and oxidative damage processes of all autoimmune diseases, especially autoimmune thyroiditis. However, we think that experimental and clinical comprehensive studies, which are detailed in sub-groups, should be conducted on this subject

Geodetic measurements on Havran-Balıkesir fault zone: First results

Havran-Balıkesir Fay Zonu (HBFZ), Batı Anadolu’daki önemli fay zonlarından birisidir. Edremit’in doğusundan, Balıkesir’e kadar KKD–GGB yönünde uzanan HBFZ iki ana fay ve altı segmentten oluşmaktadır. Fay zonu üzerinde kapsamlı paleosismolojik çalışmalar gerçekleştirilmiş ve zonun segmentlerindeki depremsizlik süreleri sismik bir boşluk (asismik hareket, krip) olarak değerlendirilmiştir. Bu nedenle, HBFZ ‘nin depremsizlik sürelerinin detaylı olarak araştırılması amacıyla, çalışma bölgesinde 55 noktadan oluşan bir GNSS ağı oluşturulmuştur. Ağdaki 21 noktada 2022 yılında bir kampanya GNSS ölçüsü gerçekleştirilmiştir. Ağda yer alan diğer sürekli ve kampanya tipi 34 noktanın ise geçmiş yıllara ait GNSS verileri çeşitli kurumlardan temin edilmiştir. Elde edilen tüm veriler GAMIT/GLOBK yazılımıyla değerlendirilmiştir. Çalışma bölgesinin Avrasya plakası sabit hız alanı 4-25 mm/yıl aralığında ve 0.18 mm/yıl doğruluğunda elde edilmiştir. Hız alanı kullanılarak, bölgenin iki boyutlu güncel jeodezik gerinim alanı hesaplanmıştır. Gerinim alanı incelendiğinde, çalışma bölgesinde KD-GB yönlü sıkışma bileşeninin baskın olduğu görülmüştür. Ek olarak, tarihsel ve aletsel dönem deprem kataloglarından yararlanılarak çalışma bölgesinin sismotektonik haritaları oluşturulmuştur. Bu sonuçlar, ilk sonuçlar olarak sunulmaktadır. HBFZ’ nin güncel deformasyonlarının ve deprem potansiyelinin belirlenmesi için jeodezik çalışmalar devam etmektedir.The Havran-Balıkesir Fault Zone (HBFZ) is one of the important fault zones in Western Anatolia. The HBFZ extending from the east of Edremit to Balıkesir in the NNE-SSW direction consists of two main faults and six segments. In the paleoseismological studies carried out on the fault zone and the earthquake -free times in the segments of the zone have been evaluated as a seismic gap (seismic movement, crip). When the geodetic studies of the region are examined, there is no geodetic study focused on HBFZ. For this reason, a GNSS network consisting of 55 points was created in the study area in order to investigate the earthquake-free times of HBFZ in detail. In 2022, a campaign-style GNSS measurement was carried out at 21 points in the network. The GNSS data of the other 34 continuous and campaign-type points in the network for the previous years were obtained from various institutions. All obtained data were evaluated with GAMIT/GLOBK software. The Eurasian plate fixed velocity field of the study area was obtained in the range of 4-25 mm/year and with an accuracy of 0.18 mm/year. By using the velocity field, the two-dimensional current geodetic strain area of the region was calculated. When the strain area is examined, it is observed that the NE-SW direction compression component is dominant in the study region. In addition, seismotectonic maps of the study area were generared by using earthquake catalogs of historical and instrumental periods. These results are presented as first results. Geodetic studies are continuing to determine the current deformations and earthquake potential of HBFZ