Melatonin decreases eye pressure in depressive patients with normal intraocular pressure

Background/Aim: In this study, we aimed to show the effect of melatonin, a pineal hormone, on intraocular pressure in patients with depression and normal ocular tension. Methods: Twenty depressive patients for whose agomelatine, a melatonin drug, was deemed necessary for treatment of the primary disease were enrolled in the study. Ocular pressures at baseline, second and fourth-week visits were recorded using a Tono-Pen and a Goldmann applanation tonometer. Results: Our study revealed that oral agomelatine therapy reduced intraocular pressure in the normotensive patients. The baseline intraocular pressure was 12.6±2.8 mm Hg with the Tono-Pen and 14.8 mm Hg with applanation tonometry. At the fourth week visit, the pressure measured with Tono-Pen was 11.5±2.9 mm-Hg and the pressure measured with applanation tonometer was 13.5±2.8 mm-Hg (p [Arch Clin Exp Surg 2019; 8(1.000): 28-32

The frequency of metabolic syndrome in psychiatric patients using antidepressant medications

WOS: 000403337900010Objective: There are limited studies investigating the metabolic syndrome (MS) in patients using antidepressants. This study examines and compares the prevalence of MS and related factors in psychiatric patients taking various antidepressants at an outpatient clinic. Methods: The study comprised a total of 70 patients using fluoxetine, paroxetine, sertralin, citalopram, essitalopram, clomipramine and venlafaxine aged 18-60 years with depressive and anxiety disorder. MS rates of patients (according to National Cholesterol Education Program-Adult Treatment Panel III-(NCEP III)) who met the study criteria were obtained. Results: In our study metabolic syndrome frequency was 32.8% in total patient groups according to NCEP-III criteria. The higher metabolic syndrome frequency was found in drug groups such as clomipramine, paroxetine and venlafaxine groups. The safest drug for metabolic syndrome was fluoxetine as seen in its relevant group. Conclusion: Conventional antidepressants may cause metabolic syndrome which is important for mortality, morbidity and quality of life of psychiatric patients

Psychiatric Symptoms and Psychosocial Problems in Patients with Breast Cancer

WOS: 000382992100001PubMed ID: 28331743Cancer is a physical disease and also one of the leading clinical manifestations where psychosocial problems are prevalent. Psychosocial problems that these patients may have in the long run include anxiety, uneasiness, mourning, helplessness, fatigue, impairment of concentration, sleep disorders, mental and cognitive reservation, sexual dysfunction, infertility, psychological distress, and psychiatric disorders. Psychosocial problems have a nature of underpinning the emergence of psychological troubles. The prevalence of psychological disorders in patients with cancer range from 29% to 47%. Psychiatric disorders that are likely to be seen are severe stress disorder, adjustment disorder, depressive disorder, and other neurotic disorders. It is considered by the present author that in the event of breast cancer, potential psychiatric disorders may affect prognosis of the disease, adherance to and success of therapy, social and societal functioning, and survival rate. This paper aims to review the psychiatric symptoms and diseases that may develop in patients with breast cancer, which is one of the most frequent types of a globally common disease; i.e., cancer, as well as the impact of psychiatric symptoms on the treatment of disease

A Case-Control Study on the Affective Temperament Profiles, Anxiety and Depression Levels of Patients with Chronic Renal Failure

WOS: 000387949500005Objectives: To determine the affective temperament profile of patients with chronic renal failure (CRF) in comparison to healthy subjects and to evaluate depression and anxiety status of patients. Methods: This was a case-control study into which 122 CRF patients (63 males, 59 females) and 100 healthy age-and gender-matched controls (66 females, 34 males) were included. The affective temperament profile was determined by Turkish version of Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A). For the assessment of depression and anxiety, the Hospital Anxiety and Depression Scale (HADS) was used. Results: Of the 122 patients, 28 (23%) were in predialysis, 22 (18%) periton dialysis, 30 (24.6%) hemodialysis and 42 (34.4%) transplantation. The majority of participants (n=169, 76.1%) had no dominant affective temperament according to TEMPS-A. For the remaining participants, the most common dominant affective temperament was depressive temperament (8.6%) followed by mixed temperament (7.7%) and anxious temperament (2.7%). There was no signifcantly difference in terms of affective temperament traits between patients and controls. Patient group had significantly higher depression and anxiety scores than healthy controls. There was no correlation between laboratory results and affective temperaments, anxiety, depression scores of patients. There was no significant difference between predialysis, periton dialysis, hemodialysis, and transplantation subgroups in terms of anxiety, depression or affective temperament traits (p>0.05 for all). Conclusion: There is no affective temperament profile specific to patients with CRF. However, considering the high rate of depression and anxiety among patients with CRF, knowing affective temperament profile of patients will guide clinicians through management of psychiatric disorders and CRF itself, thus will improve disease outcome and patients' quality of life

Increased Serum G Protein-coupled Estrogen Receptor 1 Levels and Its Diagnostic Value in Drug Naive Patients with Major Depressive Disorder

WOS: 000415134200005PubMed ID: 29073745Objective: The facts that depression is more prevalent in females than in males and females are exposed to depression more commonly during certain hormonal fluctuating periods indicate the role of sex hormones in physiopathology. Estrogen acts over estrogen receptors alpha and beta and recently identified G protein-coupled estrogen receptor 1 (GPER1). The present study aimed, for the first time, to evaluate serum GPER1 levels in drug-naive major depressive disorder (MDD) patients. Methods: The study included 56 newly diagnosed drug-naive MDD patients aged between 18 and 50 years and 42 age-and gender-matched healthy volunteers. Medical history was obtained and physical examinations, laboratory tests, and the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) were performed. The serum GPER1 levels were measured. Results: The HAM-D score was significantly higher in the MDD patients than in the controls. The GPER1 level was significantly higher in the MDD patients than in the controls. A positive correlation was found with GPER1 levels and depression scores. The receiver operating characteristic analysis revealed sensitivity, specificity, positive predictive value, and negative predictive value as 82.1%, 90.5%, 92.0%, and 79.2%, respectively, for the presence of depression, when the serum GPER1 value was >= 0.16. Conclusion: This study demonstrated significantly higher serum GPER1 levels in the MDD patients than in the controls, a positive correlation was found between GPER1 levels and depression scores and serum GPER1 level was valuable in predicting the presence of depression.Scientific Research Project Unit of Kahramanmaras Sutcu Imam University [2014/3-46 M]This study is supported by Scientific Research Project Unit of Kahramanmaras Sutcu Imam University (Project No: 2014/3-46 M)

Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naive, first episode, non-smoker major depression patients and healthy controls

WOS: 000375362300013PubMed ID: 27086215Major depression is a most frequent disorder, its diagnosis depends on pkient interview, and yet we do not have a reliable biomarker for depression. Oxidative stress is defined as increase in oxidation or decrease is antioxidant defense mechanisms. Here, we aimed to investigate malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity and their diagnostic performance in depressed patients and healthy controls. We collected blood samples from 50 patients and 50 controls. We found MDA levels were significantly higher in the patients than controls, with medians at 4.04nmol/mg and 1.64nmol/mg, respectively, p < 0.001. SOD activity was significantly decreased in depressed patients than healthy controls, with means at 143.50U/mg and 298.12U/mg, respectively, p < 0.001. CAT activity was similar in both groups, p=0.517. ROC analysis showed good diagnostic value for MDA and SOD, with the area under the curve at 1.0 for both. We found high correlation between SOD and Ham-D scores (r=0.747, p < 0.0001) and between MDA and Ham-D scores (r=0.785, p < 0.0001). Overall, these results demonstrate that oxidative stress is increased in depressed patients. MDA increase seem to be a common finding for major depression. We believe MDA could be a good biomarker candidate for major depression, but not SOD. Future studies should focus on the diagnostic value of MDA in larger samples. (C) 2016 Elsevier Ireland Ltd. All rights reserved

Psychiatric Evaluation of Organ Donor Candidates in a University Hospital and Their Anxiety, Depression and Quality of Life Levels

Amaç: Çalışmamızda organ nakli verici adaylarının psikiyatrik değerlendirmeleri, anksiyete, depresyon ve yaşam kalitesi düzeyleri araştırılması amaçlanmıştır.Yöntem: Araştırma Mayıs 2015-Şubat 2016 tarihleri arasında yürütülmüştür. Toplam 102 gönüllü çalışmaya dahil edilmiştir. Hastalara Sosyodemografik veri formu, DSM-IV Eksen Tanıları İçin Yapılandırılmış Klinik Görüşme Ölçeği-Klinik Versiyonu(SCID-I/CV) ölçeği, Beck Anksiyete Ölçeği (BAÖ), Beck Depresyon Ölçeği (BDÖ), Belirti Tarama Listesi (SCL-90-R), SF-36 Yaşam Kalitesi Ölçeği (SF-36) uygulanmıştır. Bulgular: Başvuranların yaş ortalaması 41.64±12.02 olup, %42.2'si (n=43) erkek, %57.8'i (n=59) kadındı. Verici adaylarının alıcılara olan yakınlık dereceleri; %57.8'i (n=59) 1. derece akraba, %19.6'sı (n=20) eş, %22.5'i (n=23) diğer akraba ve tanıdık idi. Yakınlık derecelerine göre yapılan gruplandırmada; BDÖ, BAÖ ve SCL-90-R toplam puanı ile kişilerarası duyarlılık ortalaması gruplar arasında anlamlı düzeyde farklılık vardı. Sonuç: Dünya ortalamasına göre ülkemizde canlı verici sayısı kadavra vericiye göre daha fazla olup, genellikle verici adayları eş, birinci derece akraba gibi yakın aile içindeki bireylerden oluşmaktadır. Bu sebeple; nakil sürecinden doğrudan ve dolaylı olarak etkilenen aile içi ve yakın akrabalar verici adayı/verici olarak daha fazla ruhsal ve sosyal yönden etkilenebilmektedirler. Nakil süreci gibi uzun bir tedavi ve bakım gerektiren bir durumu iyi yönetebilmek için alıcı yanında vericilerin de psikososyal durumlarını değerlendirerek bu sürece dahil etmek gerekmektedirPsychiatric evaluation of organ donor candidates in a university hospital and their anxiety, depression and quality of life levelsObjective: The aim of this study was to conduct a psychiatric evaluation of organ donor candidates and to investigate their levels of anxiety, depression and quality of life.Material and Methods: This study was performed between May 2015 and February 2016. It included 102 volunteers. The socio-demographic Data Collection Form, DSM-IV Clinical Interview Form – Clinical Version Structured for Axis Diagnoses (SCID-I/CV), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Symptom Checklist (SCL-90-R), and SF-36 Quality of Life Survey (SF-36) were administered to the patients. Results: The average age of the applicants was found to be 41.64±12.02, 42.2% (n=43) being male and 57.8% (n=59) being female. When it comes to the degree of affinity between potential donors and recipients, 57.8% (n=59) were first-degree relatives, 19.6% (n=20) were spouses, and 22.5% (n=23) were other relatives and/or close relations. By dividing donor candidates into groups by the degree of their affinity to recipients, there were statistically significant differences revealed between BDI, BAI and SCL-90-R total scores and interpersonal sensitivity subscale scores. Conclusion: As compared to the global average, the number of living donors is higher than cadaver donors; and donor candidates mostly comprise spouses and first-degree relatives. Therefore, family members and first-degree relatives who are affected directly or indirectly by the transplant process are exposed to social and psychological effects more as the donor candidates/donors. It is of crucial importance to evaluate the psychosocial states of donors, in addition to recipients, in order to manage the long-lasting transplant process, a treatment- and care- demanding one in a more appropriate wa

Psychiatric Evaluation of Organ Donor Candidates in a University Hospital and Their Anxiety, Depression and Quality of Life Levels

WOS: 000418008800007Objective: The aim of this study was to conduct a psychiatric evaluation of organ donor candidates and to investigate their levels of anxiety, depression and quality of life. Material and Methods: This study was performed between May 2015 and February 2016. It included 102 volunteers. The socio-demographic Data Collection Form, DSM-IV Clinical Interview Form - Clinical Version Structured for Axis Diagnoses (SCID-I/CV), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Symptom Checklist (SCL-90-R), and SF-36 Quality of Life Survey (SF-36) were administered to the patients. Results: The average age of the applicants was found to be 41.64 +/- 12.02, 42.2% (n=43) being male and 57.8% (n=59) being female. When it comes to the degree of affinity between potential donors and recipients, 57.8% (n=59) were first-degree relatives, 19.6% (n=20) were spouses, and 22.5% (n=23) were other relatives and/or close relations. By dividing donor candidates into groups by the degree of their affinity to recipients, there were statistically significant differences revealed between BDI, BAI and SCL-90-R total scores and interpersonal sensitivity subscale scores. Conclusion: As compared to the global average, the number of living donors is higher than cadaver donors; and donor candidates mostly comprise spouses and first-degree relatives. Therefore, family members and first-degree relatives who are affected directly or indirectly by the transplant process are exposed to social and psychological effects more as the donor candidates/donors. It is of crucial importance to evaluate the psychosocial states of donors, in addition to recipients, in order to manage the long-lasting transplant process, a treatment- and care-demanding one in a more appropriate way